公开(公告)号：US20150177211A1

公开(公告)日：2015-06-25

申请号：US14591258

申请日：2015-01-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Ching-Ying CHEUNG ,  Diane GRAY ,  Stephen YUE

IPC: G01N33/18 ,  C07D401/14 ,  G01N21/64 ,  C07D417/06

CPC classification number: G01N33/1806 ,  C07D211/62 ,  C07D295/112 ,  C07D401/14 ,  C07D417/06 ,  C07D417/14 ,  C09B23/04 ,  C12Q1/04 ,  C12Q1/18 ,  G01N21/643 ,  G01N33/52 ,  G01N33/582 ,  G01N2021/6432

Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.