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    FLUID MIXING SYSTEM WITH LATERALLY DISPLACED FLEXIBLE DRIVE LINES AND METHODS OF USE
    1.
    发明申请
    FLUID MIXING SYSTEM WITH LATERALLY DISPLACED FLEXIBLE DRIVE LINES AND METHODS OF USE 审中-公开
    带有柔性驱动线的流体混合系统和使用方法

    公开(公告)号：WO2017116909A1

    公开(公告)日：2017-07-06

    申请号：PCT/US2016/068064

    申请日：2016-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： JONES, Nephi D. ,  BRAU, Christopher D.

    IPC: B01F7/00 ,  B01F15/00

    CPC classification number: C12M27/02 ,  B01F7/0005 ,  B01F7/00341 ,  B01F7/00383 ,  B01F7/00566 ,  B01F7/00633 ,  B01F7/00641 ,  B01F7/00675 ,  B01F7/22 ,  B01F15/00707 ,  B01F15/0085 ,  B01F2215/0073 ,  C12M23/14 ,  C12M23/26

    Abstract: A fluid mixing system (164, 422, 430) includes a container (14, 16, 18B, 18) bounding a compartment (28) and extending between a first end (191, 405, 432, 450, 464, 502, 512, 58, 70, 84) and an opposing second end (192, 407, 434, 452, 466, 504, 514, 60, 72, 86). An elongated, flexible first drive line (44A, 44B, 44) and second drive line (44B) are disposed within the compartment (28) of the container (14, 16, 18B, 18) and are rotatable therein. At least one tie (45A, 45) extends between the first drive line (44A, 44B, 44) and the second drive line (44B) so as to maintain at least a portion of the first drive line (44A, 44B, 44) and the second drive line (44B) at lateral spaced apart positions within the compartment (28). An impeller (46A, 46B, 46C, 46) or other mixing element (400A, 400) can be coupled to the drive lines (44A, 44, 45A).

    Abstract translation: 流体混合系统（164,422,430）包括界定隔室（28）并且在第一端（191,405,432,430）和第二端（191,402,432）之间延伸的容器（14,16,18B，18） （464,504,450,464,502,512,58,70,84）和相对的第二端（192,407,434,452,466,504,514,60,72,86）。 细长的柔性第一驱动线路（44A，44B，44）和第二驱动线路（44B）设置在容器（14,16,18B，18）的隔间（28）内并且可在其中旋转。 在第一驱动线路（44A，44B，44）和第二驱动线路（44B）之间延伸有至少一个连接件（45A，45）以便保持第一驱动线路（44A，44B，44）的至少一部分， 和所述第二驱动线路（44B）在所述隔室（28）内的侧向间隔开的位置处。 叶轮（46A，46B，46C，46）或其他混合元件（400A，400）可以联接到驱动线路（44A，44,45A）。

    FLUID MIXING SYSTEMS WITH MODULAR IMPELLERS AND RELATED METHODS
    2.
    发明申请
    FLUID MIXING SYSTEMS WITH MODULAR IMPELLERS AND RELATED METHODS 审中-公开

    公开(公告)号：WO2021158555A1

    公开(公告)日：2021-08-12

    申请号：PCT/US2021/016224

    申请日：2021-02-02

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： JONES, Nephi D. ,  BROWN, Jason D.

    IPC: B01F7/00 ,  B01F15/00 ,  B01F15/06

    Abstract: A mixing system for mixing a liquid includes a first impeller segment (170A) having a first mount (172A) and a first mixing blade (174A) secured to the first mount (172A) and a second impeller segment (170B) having a second mount (172B) and a first mixing blade (174B) secured to the second mount (172B), the second impeller segment (170B) being separate and discrete from the first impeller segment (170A). One or more drive members are secured to the first impeller segment (170A) and the second impeller segment (170B) for concurrently rotating the first impeller segment (170A) and the second impeller segment (170B) about a rotational axis (171). The first impeller segment (170A) and the second impeller segment (170B) are secured to the one or more drive members so that a plane (210) extending normal to the axis (171) of rotation intersects with the first mixing blade (174A) of the first impeller segment (170A) and the first mixing blade (174A) of the second impeller segment (170B).

    CONTINUOUS SAMPLE PURIFICATION SYSTEMS AND METHODS
    3.
    发明申请
    CONTINUOUS SAMPLE PURIFICATION SYSTEMS AND METHODS 审中-公开
    连续样品净化系统和方法

    公开(公告)号：WO2017116911A1

    公开(公告)日：2017-07-06

    申请号：PCT/US2016/068072

    申请日：2016-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： COLLINS, Scott P. ,  RODRIGUEZ PERALTA, Federico Carols ,  JONES, Nephi D. ,  BRAU, Christopher D.

    IPC: B01D11/02 ,  B01D11/04

    CPC classification number: B01D11/02 ,  B01D11/0284 ,  B01D11/0446 ,  B01D11/0457 ,  B01D11/0488 ,  B01D11/0492

    Abstract: Sample purification systems include a particle extraction assembly having a mixing compartment and a settling compartment. A biological sample is mixed with two liquid phases formulated to effectuate transfer of a biological molecule into a first phase and particulate contaminants into a second phase. The first phase includes a solubilizing salt, the second phase includes an organic molecule, and the mixture can have little or no monoatomic salt or dextran. The molecule-containing first phase can be optionally concentrated without also concentrating the particulate contaminants and introduced into a multi-stage liquid-liquid extractor, by which the biological molecule or molecular contaminants are extracted from the first phase into a third phase, thereby purifying the molecule away from contaminants. The extracted sample can be further purified through a series of processing steps. The system can be run in continuously mode to maintain sterility of the sample.

    Abstract translation: 样品纯化系统包括具有混合室和沉降室的颗粒提取组件。 将生物样品与两个配制的液相混合以实现生物分子转移到第一相中，并将颗粒污染物转移到第二相中。 第一阶段包括增溶盐，第二阶段包括有机分子，并且混合物可以具有很少或不具有单原子盐或葡聚糖。 含有分子的第一相可以任选地浓缩而不浓缩颗粒污染物并引入到多级液 - 液萃取器中，由此将生物分子或分子污染物从第一相萃取到第三相中，从而纯化 分子远离污染物。 提取的样品可以通过一系列处理步骤进一步纯化。 系统可连续运行以保持样品的无菌性。

    ACOUSTICALLY SETTLED LIQUID-LIQUID SAMPLE PURIFICATION SYSTEM
    4.
    发明申请
    ACOUSTICALLY SETTLED LIQUID-LIQUID SAMPLE PURIFICATION SYSTEM 审中-公开
    主要液体液体样品纯化系统

    公开(公告)号：WO2016065249A1

    公开(公告)日：2016-04-28

    申请号：PCT/US2015/057095

    申请日：2015-10-23

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： COLLINS, Scott P. ,  BRAU, Christopher D. ,  JONES, Nephi D.

    IPC: B01D11/04 ,  G01N1/40 ,  B01D17/04

    CPC classification number: B01D11/0423 ,  B01D11/043 ,  B01D11/0449 ,  B01D11/0457 ,  G01N1/34 ,  G01N2001/4061

    Abstract: A sample purification system includes a container assembly bounding a sample purification compartment and having an upper end and an opposing lower end, the sample purification compartment comprising mixing zones and settling zones. A plurality of shielding elements are positioned within the sample purification compartment so as to at least partially separate adjacent mixing zones and settling zones or separate adjacent mixing zones, the mixing zones being in fluid communication with the settling zones. A mixing element is disposed within each mixing zone. An acoustic wave settler is aligned with a portion of the container assembly, the acoustic wave settler being configured to emit an acoustic wave through the portion of the container assembly and a mixture disposed therein, the acoustic wave coalescing fluid phase droplets disposed in the mixture to increase the buoyancy or density of the fluid phase droplets.

    Abstract translation: 样品净化系统包括界定样品净化室并具有上端和相对的下端的容器组件，样品净化室包括混合区和沉降区。 多个屏蔽元件位于样品净化室内，以便至少部分地分离相邻的混合区域和沉降区域或分离相邻的混合区域，混合区域与沉降区域流体连通。 混合元件设置在每个混合区内。 声波沉降器与容器组件的一部分对准，声波沉降器被配置为通过容器组件的一部分和布置在其中的混合物发射声波，声波将布置在混合物中的流体相液滴聚结到 增加流体相液滴的浮力或密度。

    FLEXIBLE BIOPROCESSING CONTAINER WITH PARTIAL DIVIDING PARTITION
    6.
    发明申请
    FLEXIBLE BIOPROCESSING CONTAINER WITH PARTIAL DIVIDING PARTITION 审中-公开
    具有局部分割分区的柔性生物加工容器

    公开(公告)号：WO2017116910A1

    公开(公告)日：2017-07-06

    申请号：PCT/US2016/068067

    申请日：2016-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGIES AS

    Inventor： NORDERHAUG, Lars ,  VARELA-ROHENA, Angel ,  JONES, Nephi D.

    IPC: B03C1/01 ,  B03C1/28 ,  B03C1/30 ,  B01L3/00 ,  C12M1/00 ,  A61M1/36

    CPC classification number: B03C1/01 ,  A61M1/3618 ,  B01L3/505 ,  B01L2200/0668 ,  B01L2400/043 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

    Abstract: Methods of separating magnetic particles from a fluid include introducing a fluid mixture that includes a liquid media, a biological component, and magnetic particles into an internal compartment of a container through an inlet, allowing at least a portion of the mixture to travel around a partition formed within the internal compartment and then exit the internal compartment through an outlet on the opposite side of the partition, and applying a magnetic field to the mixture in the internal compartment so that the magnetic particles are retained within the container or internal compartment thereof by the magnetic field. The partition is formed by permanently or reversibly securing upper and lower container walls together, such as by welding or pressing, between the inlet and the outlet such that the media and biological component must flow around the partition and through the magnetic field to exit the internal compartment through the outlet.

    Abstract translation: 从流体分离磁性颗粒的方法包括通过入口将包括液体介质，生物成分和磁性颗粒的流体混合物引入容器的内部隔室中，从而允许至少一部分 的混合物在内部隔室内形成的隔板周围行进，然后通过隔板另一侧的出口离开内部隔室，并向内部隔室的混合物施加磁场，以使磁性颗粒保留在内部 容器或其内部隔室受到磁场的影响。 通过将入口和出口之间的上部容器壁和下部容器壁永久地或可逆地固定在一起（例如通过焊接或挤压）形成隔板，使得介质和生物成分必须在隔板周围流动并穿过磁场流出内部 通过出口的隔间。

    GAS FILTER SYSTEMS FOR FLUID PROCESSING SYSTEMS
    8.
    发明公开
    GAS FILTER SYSTEMS FOR FLUID PROCESSING SYSTEMS 审中-公开

    公开(公告)号：EP4269554A2

    公开(公告)日：2023-11-01

    申请号：EP23192479.6

    申请日：2014-12-31

    Applicant: Life Technologies Corporation

    Inventor： BROWN, Jason D. ,  STAHELI, Clinton C. ,  JONES, Nephi D.

    IPC: C12M1/12

    Abstract: A filter assembly includes a casing having of a polymeric film and bounding a compartment, the casing having an inlet opening communicating with the compartment and a first outlet opening communicating with the compartment. A first filter includes a porous filter body through which gas can pass and has a pore size smaller than 1 µm, the first filter being coupled with the casing so that the filter body is at least partially disposed within compartment of the casing and so that gas passing through the compartment of the casing from the inlet opening to the first outlet opening must pass through the filter body.

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