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1.发明申请MODIFIED NUCLEIC ACID BINDING CYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES 审中-公开用于检测反应性氧物种的改性核酸结合氰胺染料
公开(公告)号：WO2013148038A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/027805
申请日：2013-02-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： HU, Yi-Zhen , CHEN, Aimei , KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar
IPC: C09B23/02 , C09B23/04 , C09B23/06 , G01N33/533 , G01N33/58
Abstract: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo . Also described herein are processes for preparing novel reduced dyes, i.e ., ROS probes, for use in the disclosed compositions, methods and kits.
Abstract translation: 本文公开了通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原性核酸结合花青染料，其染料是用于检测体内和/或体内细胞中ROS和测量氧化应激的探针。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。
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Patent Agency Ranking2.发明申请
公开(公告)号：WO2012061403A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058806
申请日：2011-11-01
Applicant: LIFE TECHNOLOGIES CORPORATION , KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar , YING, Lai-Qiang , BRANCHAUD, Bruce
Inventor： KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar , YING, Lai-Qiang , BRANCHAUD, Bruce
CPC classification number: G01N21/6486 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
Abstract: ABSTRACT Described herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
Abstract translation: 摘要本文描述了通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原染料，包括基于Cy的氢化花青染料和Cy-基氘异氰染料，其染料是用于检测ROS的探针和测量体外和/或体内细胞中的氧化应激。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。
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3.发明公开MODIFIED HYDROCYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES 有权改进HYDROCYANINFARBSTOFFE一种判别活性氧
公开(公告)号：EP2635350A1
公开(公告)日：2013-09-11
申请号：EP11838687.9
申请日：2011-11-01
Applicant: Life Technologies Corporation
Inventor： KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar , YING, Lai-Qiang , BRANCHAUD, Bruce
CPC classification number: G01N21/6486 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
Abstract: The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
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4.发明授权
公开(公告)号：EP2831179B1
公开(公告)日：2016-04-20
申请号：EP13709645.9
申请日：2013-02-26
Applicant: Life Technologies Corporation
Inventor： HU, Yi-Zhen , CHEN, Aimei , KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar
IPC: C09B23/02 , C09B23/04 , C09B23/06 , G01N33/533 , G01N33/58
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公开(公告)号：EP2635350B1
公开(公告)日：2018-03-07
申请号：EP11838687.9
申请日：2011-11-01
Applicant: Life Technologies Corporation
Inventor： KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar , YING, Lai-Qiang , BRANCHAUD, Bruce
CPC classification number: G01N21/6486 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
Abstract: The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
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6.发明公开
公开(公告)号：EP2831179A1
公开(公告)日：2015-02-04
申请号：EP13709645.9
申请日：2013-02-26
Applicant: Life Technologies Corporation
Inventor： HU, Yi-Zhen , CHEN, Aimei , KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar
IPC: C09B23/02 , C09B23/04 , C09B23/06 , G01N33/533 , G01N33/58
Abstract: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either
in vitro and/or
in vivo . Also described herein are processes for preparing novel reduced dyes,
i.e ., ROS probes, for use in the disclosed compositions, methods and kits.
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