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公开(公告)号:WO2017066707A1
公开(公告)日:2017-04-20
申请号:PCT/US2016/057224
申请日:2016-10-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: XU, Xin , LIANG, Xiquan , DE MOLLERAT DU JEU, Xavier , POTTER, Robert Jason
CPC classification number: C12N15/90 , A61K48/0033 , A61K48/005 , C12N9/22 , C12N15/88 , C12N2830/30 , C12Y301/00
Abstract: Provided herein are compositions and methods useful, inter alia , for the delivery of ribonucleoprotein complexes (e.g., Cas9/guide RNA complexes) into cells. The compositions and methods provided herein are particularly useful for the delivery of ribonucleoprotein complexes into pluripotent cells and lymphatic cells.
Abstract translation: 本文提供了用于将核糖核蛋白复合物(例如Cas9 /引导RNA复合物)递送入细胞的组合物和方法,尤其是用于其他方面的组合物和方法。 本文提供的组合物和方法对于将核糖核蛋白复合物递送到多能细胞和淋巴细胞中是特别有用的。 p>