公开(公告)号：WO1994006105A1

公开(公告)日：1994-03-17

申请号：PCT/US1993007386

申请日：1993-08-06

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, Russell ,  ANDREWS, Winston, A.

IPC: G08C17/00

CPC classification number: A61B90/98 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/117 ,  A61B5/411 ,  A61F2250/0002 ,  G08C17/04

Abstract: A passive electrical transponder (20) may be encoded with a code corresponding to medical information, and the transponder (20) directly transplanted in a patient's underarm area (22). The information may then be accessed with an electromagnetic hand held reader (26) which is brought into proximity of the transponder (20). The medical information may itself be directly encoded into the transponder (20), or a code used which is then keyed to a corresponding data entry in a data bank (30) accessible over telecommunication lines (32). With this invention, medical information may be reliably recorded, maintained, and accessed with minimal patient involvement in order to achieve a high degree of reliability and accuracy.

Abstract translation: 无源电转发器（20）可以用对应于医疗​​信息的代码进行编码，并且应答器（20）直接移植到患者的腋下区域（22）中。 然后可以利用电磁手持读取器（26）来访问该信息，该读取器（26）进入到应答器（20）附近。 医疗信息本身可以直接编码到应答器（20）中，或者所使用的代码，然后键入到通过电信线路（32）可访问的数据库（30）中的相应数据条目。 利用本发明，可以以最小的患者参与可靠地记录，维护和访问医疗信息，以实现高可靠性和准确性。

公开(公告)号：WO1998010803A1

公开(公告)日：1998-03-19

申请号：PCT/EP1997005038

申请日：1997-09-15

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, R. ,  ANDREWS, Winston, A. ,  COMTE, Pierre

IPC: A61L27/00

CPC classification number: A61F2/12 ,  A61L27/56

Abstract: The invention relates to a tissue implant having visco-elastic characteristics which simulate the natural tissue that is intended to be augmented or replaced. The implant is comprised of a shell or envelope enclosing a compound foam body and a fluid filler material. Both the foam body and the fluid filler should be biocompatible and preferably are substantially radiolucent using standard mammographic materials and protocols. The compound foam body is of elastomeric cellular foam materials. Intercellular communication of the fluid filler provides a hydraulic mechanism for imparting shape and tissue-like consistency to the implant. The compound foam body has multiple regions, each region having a different cellular density, for simulating the tactile characteristics of the natural tissue that the implant is intended to augment or replace. The implant may also have a cavity in the compound foam body configured for providing a hydraulic reservoir for the fluid filler. The resiliency of the compound foam body permits realistic elastic deformation, in response to external pressure, and "rebound" following such deformation.

Abstract translation: 本发明涉及具有粘弹性特性的组织植入物，其模拟旨在增加或替换的天然组织。 植入物由围绕复合泡沫体和流体填充材料的外壳或信封构成。 泡沫体和流体填充物都应该是生物相容性的，并且优选地使用标准乳房X射线照相材料和方案实质上是可透射的。 复合泡沫体是弹性体泡沫材料。 流体填充物的细胞间通信提供了用于赋予植入物形状和组织样稠度的液压机构。 复合泡沫体具有多个区域，每个区域具有不同的细胞密度，用于模拟植入物旨在增加或替代的天然组织的触觉特性。 所述植入物还可以具有在所述复合泡沫体中具有用于为所述流体填充物提供液压储存器的空腔。 复合泡沫体的弹性允许响应于外部压力的现实弹性变形和这种变形之后的“回弹”。

公开(公告)号：WO1995025549A1

公开(公告)日：1995-09-28

申请号：PCT/US1994012394

申请日：1994-11-04

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, R. ,  ANDREWS, Winston, A. ,  DUMLAO, Gloria, R.

IPC: A61L27/00

CPC classification number: A61L27/00 ,  A61F2/08 ,  A61F2/12 ,  A61F2/26 ,  A61L27/50

Abstract: A filler material for a surgically implantable prosthesis comprised of a synthetic triglyceride having a viscosity substantially greater than that of naturally occurring triglycerides is provided. The triglyceride composition is formed of saturated alkyl chains to reduce or limit the potential for oxidation of the alkyl chains to form peroxide groups which adversely affect the biocompatibility of the filler material and the implant. Preferably, the filler material has a viscosity substantially the equivalent of a normal human breast. The synthetic triglyceride filler material may also have a lower viscosity which is a liquid at room temperature for use in inflatable devices. Prostheses containing filler material having the desired viscosity and antioxidation characteristics are also provided as well as a method for preparing the filler material.

Abstract translation: 提供了一种用于手术可植入的假体的填充材料，其由具有比天然存在的甘油三酯的粘度显着更大的粘度的合成甘油三酯组成。 甘油三酸酯组合物由饱和烷基链形成，以减少或限制烷基链氧化的可能性，形成对填料和植入物的生物相容性产生不利影响的过氧化物基团。 优选地，填充材料具有基本上等于正常人乳房的粘度。 合成甘油三酯填料也可以具有较低的粘度，其在室温下是用于充气装置的液体。 还提供了含有具有所需粘度和抗氧化特性的填充材料的假体以及制备填充材料的方法。

公开(公告)号：WO1996039099A1

公开(公告)日：1996-12-12

申请号：PCT/EP1996001349

申请日：1996-03-27

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, R. ,  BELSEY, Elizabeth, Mary

IPC: A61F02/02

CPC classification number: G08C17/04 ,  A01K11/006 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/117 ,  A61B17/746 ,  A61B17/8085 ,  A61B90/39 ,  A61B90/98 ,  A61B2562/08 ,  A61F2/02 ,  A61F2/12 ,  A61F2/26 ,  A61F2/38 ,  A61F2/40 ,  A61F2/4241 ,  A61F2002/2807 ,  A61F2002/3008 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30677 ,  A61F2002/3071 ,  A61F2250/0002 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61F2250/0085 ,  A61F2250/0098 ,  A61F2310/00023 ,  Y10S623/914

Abstract: A passive transponder (28) may be encoded with a binary number or code of 64 bits or more and then associated with or mounted to virtually any implant intended for implantation in a human including temporary implants such as drug release implants (130) and organ displacement devices (134). After implantation, the transponder's code may be conveniently read with a hand-held electromagnetic reader (34) which may merely be brought within proximity of the transponder (28). The encoded transponder (28) may thus be read in a non-invasive procedure and without the use of any sophisticated or potentially harmful medical equipment or technology such as X-rays. Where the position of the implant in the human changes over time, or is otherwise unknown to attending medical personnel, the transponder and implant can be located by using a strength of signal indicator on the electromagnetic reader (34). The information encoded in the transponder may simply be a tag for locating the implant, or may correspond to patient demographics and implant data to aid in tracking the implant and patient for medical as well as legal reasons.

Abstract translation: 无源应答器（28）可以用二进制数或64位或更多的代码进行编码，然后与实际上用于植入人的任何植入物相关联或安装在包括暂时植入物（例如药物释放植入物（130））和器官移位 设备（134）。 在植入之后，可以用手持电磁读取器（34）方便地读取应答器的代码，该读取器（34）可能只能被放置在应答器（28）附近。 编码的应答器（28）因此可以非侵入性的程序读取，并且不使用任何复杂的或潜在有害的医疗设备或技术例如X射线。 在人类中植入物的位置随着时间的推移而变化，或者对于参加医务人员而言是未知的，可以通过在电磁读取器（34）上使用信号指示器的强度来定位应答器和植入物。 在应答器中编码的信息可以简单地是用于定位植入物的标签，或者可以对应于患者人口统计学和植入物数据，以帮助跟踪植入物和患者进行医疗以及法律上的理由。

公开(公告)号：WO1994010937A1

公开(公告)日：1994-05-26

申请号：PCT/US1993007383

申请日：1993-08-06

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, Russell ,  DANIELS, John, R.

IPC: A61F02/02

CPC classification number: A61L27/50 ,  A61B90/00 ,  A61B2017/00902 ,  A61B2090/0815 ,  A61L27/18 ,  C08L75/04

Abstract: A temporarily implantable organ displacement implant (20) is comprised of a bladder (22) with a one-way valve (26) for being filled with a fluid for displacement of a healthy organ from a tissue site desired to be irradiated by radiation therapy. The organ displacement implant (20) is substantially radiolucent which thereby facilitates its placement and minimizes its interference with the radiation therapy.

Abstract translation: 临时可植入器官置换植入物（20）包括具有单向阀（26）的囊（22），用于填充用于将健康器官从期望被辐射治疗照射的组织部位移位的流体。 器官置换植入物（20）基本上是可透射的，由此有利于其放置并使其与放射治疗的干扰最小化。

公开(公告)号：WO1996022058A1

公开(公告)日：1996-07-25

申请号：PCT/IB1996000172

申请日：1996-01-19

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, R. ,  STEUART, John

IPC: A61B19/00

CPC classification number: A61F2/02 ,  A61B5/076 ,  A61B5/117 ,  A61B5/413 ,  A61B90/39 ,  A61B90/98 ,  A61F2250/0098 ,  Y10S623/912

Abstract: A passive transponder may be encoded with a number or code up to 64 binary bits and then associated with or mounted to virtually any living tissue implant for implantation in a human. After implantation, the transponder's code may be conveniently read with a hand held electromagnetic reader which may merely be brought within proximity of the transponder. The encoded transponder may thus be read in a non-invasive procedure and without the use of any sophisticated or potentially harmful medical equipment or technology such as X-ray. The information encoded in the transponder may correspond to patient demographics and implant data to aid in tracking the implant's progress and use for medical as well as legal reasons. The living tissue can be living organ from a donor transplanted into a recipient patient.

Abstract translation: 无源应答器可以用多达64个二进制位的数字或代码进行编码，然后与几乎任何用于植入人体的活体组织植入物相关联或安装在其上。 植入后，可以用手持式电磁读取器方便地读取应答器的代码，手持式电磁读取器可能只能被置于应答器的附近。 因此编码的应答器可以非侵入性的程序读取而不使用任何复杂的或潜在有害的医疗设备或技术，如X射线。 在应答器中编码的信息可以对应于患者人口统计学和植入物数据，以帮助跟踪植入物的进展并且用于医疗和法律上的原因。 生物体组织可以是移植到受体患者中的供体的活体器官。

公开(公告)号：WO1995012419A2

公开(公告)日：1995-05-11

申请号：PCT/US1994012376

申请日：1994-11-04

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  ANDREWS, Winston, A. ,  NELSON, David ,  NOVY, Richard, W.

IPC: A61L27/00

CPC classification number: A61L27/18 ,  A61F2/12 ,  A61L27/56 ,  C08J9/26 ,  C08J2201/044 ,  C08J2203/02 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2383/04 ,  C08L83/04

Abstract: A method for forming an open cell texturized surface in a silicone elastomer layer of a breast implant, or other medical implant, is created by forming a layer of uncured silicone elastomer, applying a coating of particles to the surface thereof, and curing the layer by heating it at an elevated temperature which also volatilizes the particles such that their constituent gases boil through the surface of the layer and create the texturing.

Abstract translation: 通过形成未固化的硅氧烷弹性体层，在其表面上施加颗粒涂层，并通过以下步骤固化该层，从而产生用于在乳房植入物或其它医疗植入物的有机硅弹性体层中形成开放细胞纹理化表面的方法 在升高的温度下加热，这也使颗粒挥发，使得其组成气体沸腾穿过层的表面并产生纹理化。

公开(公告)号：WO1994004094A1

公开(公告)日：1994-03-03

申请号：PCT/US1993007499

申请日：1993-08-05

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, Russell ,  MONSEES, Thomas, Lawrence ,  ANDREWS, Winston, A.

IPC: A61F02/02

CPC classification number: A01K11/006 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/117 ,  A61B17/746 ,  A61B17/8085 ,  A61B90/39 ,  A61B90/98 ,  A61B2562/08 ,  A61F2/02 ,  A61F2/12 ,  A61F2/26 ,  A61F2/38 ,  A61F2/40 ,  A61F2/4241 ,  A61F2002/2807 ,  A61F2002/3008 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30677 ,  A61F2002/3071 ,  A61F2250/0002 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61F2250/0085 ,  A61F2250/0098 ,  A61F2310/00023 ,  G06F19/00 ,  G08C17/04 ,  Y10S623/912 ,  Y10S623/914

Abstract: A passive transponder (28) may be encoded with a number or code of up to 64 binary bits and then mounted to virtually any prosthesis implanted in a human, such as a breast implant. After implantation, the transponder's code may be conveniently read with a hand held electromagnetic reader (24) which may merely be brought within proximity of the transponder (28). The encoded transponder (28) may thus be read in a non-invasive procedure and without the use of any sophisticated or potentially harmful medical equipment or technology such as X-ray. The information encoded in the transponder (28) may correspond to patient demographics and implant data to aid in tracking the implant's manufacturer and use for medical as well as legal reasons.

Abstract translation: 无源应答器（28）可以用多达64个二进制位的数字或代码进行编码，然后安装到实际上植入在人体中的假体，例如乳房植入物。 在植入之后，可以用手持电磁读取器（24）方便地读取应答器的代码，该读取器（24）可能仅被置于应答器（28）的附近。 编码的应答器（28）因此可以以非侵入性程序读取，并且不使用诸如X射线的任何复杂或潜在有害的医疗设备或技术。 在应答器（28）中编码的信息可以对应于患者人口统计学和植入物数据，以帮助跟踪植入物的制造商以及用于医疗和法律上的原因。

公开(公告)号：WO1997033513A1

公开(公告)日：1997-09-18

申请号：PCT/IB1997000537

申请日：1997-03-11

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry ,  KOVACS, Gregory, T., A.

IPC: A61B05/00

CPC classification number: A61B1/00029 ,  A61B1/00016 ,  A61B1/041 ,  A61B1/0653 ,  A61B1/0684 ,  A61B5/0031 ,  A61B5/413 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2562/08 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0291 ,  G06F19/00

Abstract: A biosensing transponder for implantation in an organism including a human comprises a biosensor for sensing one or more physical properties related to the organism after the device has been implanted, including optical, mechanical, chemical, and electrochemical properties, and a transponder for wirelessly transmitting data corresponding to the sensed parameter value to a remote reader. Disclosed embodiments utilize temperature sensors, strain sensors, pressure sensors, magnetic sensors, acceleration sensors, ionizing radiation sensors, acoustic wave sensors, chemical sensors including direct chemical sensors and dye based chemical sensors, and photosensors including imagers and integrated spectrophotometers. The transponder includes an energy coupler for wirelessly energizing the device with a remote energy source, and a control circuit for controlling and accessing the biosensor and for storing identifying data. The energy coupler can be an inductive circuit for coupling electromagnetic energy, a photoelectric transducer for coupling optical energy, or a piezoelectric transducer for coupling ultrasonic energy. The control circuit can be configured to delay, either randomly or by a fixed period of time, transmission of data indicative of the sensed parameter value to thereby prevent a data collision with an adjacent like device. Methods for using an implantable biosensing transponder include the steps of associating the device with an implant, including temporary implants, prostheses, and living tissue implants, physically attaching the device to a flexible catheter, sensing parameter values in an organism, and transmitting data corresponding to the sensed parameter values to a remote reader.

Abstract translation: 用于植入包括人的生物体的生物传感应答器包括用于感测在器件植入之后与生物相关的一种或多种物理性质的生物传感器，包括光学，机械，化学和电化学性质，以及用于无线传输数据的应答器 对应于感测到的远程读取器的参数值。 公开的实施例使用温度传感器，应变传感器，压力传感器，磁传感器，加速度传感器，电离辐射传感器，声波传感器，包括直接化学传感器和基于染料的化学传感器的化学传感器，以及包括成像器和集成分光光度计的光电传感器。 应答器包括能量耦合器，用于利用远程能量源无线地激励装置，以及用于控制和访问生物传感器并用于存储识别数据的控制电路。 能量耦合器可以是用于耦合电磁能的感应电路，用于耦合光能的光电传感器，或用于耦合超声波能量的压电传感器。 控制电路可以被配置为随机地或者在固定的时间段内延迟指示所感测的参数值的数据的传输，从而防止与相邻的类似设备的数据冲突。 使用植入式生物传感应答器的方法包括以下步骤：将装置与植入物相关联，包括临时植入物，假体和活组织植入物，将装置物理地附接到柔性导管，感测生物体中的参数值，以及发送对应于 感测到的参数值给远程读取器。

公开(公告)号：WO1996022049A1

公开(公告)日：1996-07-25

申请号：PCT/IB1996000213

申请日：1996-01-19

Applicant: LIPOMATRIX INCORPORATED

Inventor： LIPOMATRIX INCORPORATED ,  KNAPP, Terry, R.

IPC: A61B05/00

CPC classification number: A61B5/411 ,  A61B5/0031 ,  A61B5/076 ,  A61B90/98 ,  A61B2562/08 ,  A61F2/02 ,  A61F2250/0002 ,  A61F2250/0098 ,  G06F19/00 ,  G08C17/04 ,  Y10S623/914

Abstract: A passive transponder (20) implanted in a patient's underarm area (22) may be encoded with a code corresponding to the patient´s identity and to medical information. The code may be accessed with an electromagnetic hand-held reader (26) which is brought into proximity of the transponder (20). The medical information may itself be directly encoded into the transponder (20), or a code used which is then keyed to a corresponding data entry in a data bank (30) accessible over telecommunication lines. Medical information may be reliably and confidentially recorded, maintained, and accessed with minimal patient involvement and may be centrally collected over an extended time period and analyzed to generate recall notices, provide generalized health information and improve health care for all participants.

Abstract translation: 植入患者腋下区域（22）的被动转发器（20）可以用对应于患者身份的代码和医疗信息进行编码。 代码可以通过电磁手持式读取器（26）来访问，该读取器（26）进入到应答器（20）附近。 医疗信息本身可以直接编码到应答器（20）中，或者使用的代码，然后键入到可通过电信线路访问的数据库（30）中的对应数据条目。 医疗信息可以以最小的患者参与可靠和保密地记录，维护和访问，并且可以在更长的时间内集中收集并分析以产生召回通知，提供广泛的健康信息并改善对所有参与者的保健。