公开(公告)号：US09453812B2

公开(公告)日：2016-09-27

申请号：US14313377

申请日：2014-06-24

Applicant: LifeScan Scotland Limited

Inventor： Alexander Cooper ,  Antony Smith ,  Lynsey Whyte ,  Neil Whitehead ,  David McColl ,  Brian Guthrie ,  Timothy Lloyd ,  Rossano Massari ,  Christian Forlani

IPC: G01N17/00 ,  G01N27/327 ,  G01N33/00 ,  G01N30/64 ,  G01N31/16

CPC classification number: G01N27/327 ,  B01L2300/0645 ,  G01N27/3272 ,  G01N31/164 ,  G01N33/0031 ,  G01N2030/645

Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner.

Abstract translation: 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特征（例如，血细胞比容）的基于电化学的分析测试条包括样品 具有设置在基于电化学的分析测试条的端部边缘上的样品施加开口的第一和第二样品室，以及与样品入口室直接流体连通的第一和第二样品测定室。 基于电化学的分析测试条还包括设置在第一样品测定室中的第一和第二电极（例如第一和第二血细胞比容电极）和设置在第二样品中的第三和第四电极（例如工作和参考电极） 测定室。 此外，第一和第二样品确定室将样品入口室彼此垂直（或几乎垂直）相交，并且第一样品测定室也以对准的方式与样品入口室相交。

公开(公告)号：US20140353176A1

公开(公告)日：2014-12-04

申请号：US13909970

申请日：2013-06-04

Applicant: LifeScan Scotland Limited

Inventor： David ELDER ,  Rossano Massari

IPC: G01N27/416

CPC classification number: A61B5/14532 ,  A61B5/14535 ,  G01N33/48792

Abstract: A hand-held test meter for use with an analytical test strip in determining an analyte in a fluid sample includes a housing retaining a microcontroller block and a phase-shift-measurement block. The measurement block includes a signal-generation sub-block that provides an excitation voltage signal; an interface sub-block that receives the analytical test strip and permits applying the voltage excitation signal to the test strip to provide a resultant current signal; a transimpedance conversion sub-block that receives the resultant current signal and provides a resultant voltage signal; and a phase detector responsive to the resultant voltage signal and a reference signal. The microcontroller block successively provides 0°- and 90°-phase reference signals as the reference to the phase detector to measure in-phase and quadrature components and determine a phase shift corresponding to a fluid sample in the received analytical test strip.

Abstract translation: 用于测定流体样品中的分析物的分析测试条的手持测试仪包括保持微控制器模块和相移测量模块的壳体。 测量块包括提供激励电压信号的信号产生子块; 接口子块，其接收分析测试条，并且允许将电压激励信号施加到测试条以提供合成的电流信号; 跨阻变换子块，其接收所得到的电流信号并提供合成的电压信号; 以及响应于所得到的电压信号和参考信号的相位检测器。 微控制器块连续提供0°和90°相位参考信号作为相位检测器的参考，以测量同相和正交分量，并确定对应于接收到的分析测试条中的流体样品的相移。

公开(公告)号：US09470649B2

公开(公告)日：2016-10-18

申请号：US14300454

申请日：2014-06-10

Applicant: LifeScan Scotland Limited

Inventor： David Elder ,  Rossano Massari

IPC: G01R23/20 ,  G01N27/26 ,  G01N27/327 ,  G01R29/26

CPC classification number: G01N27/3273 ,  G01N27/3271 ,  G01N27/3274 ,  G01R23/20 ,  G01R29/26

Abstract: A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, a clock module disposed in the housing, a micro-controller disposed in the housing, a low-distortion signal generation circuit block (“LDSGCB”) disposed in the housing, and a strip port connector configured to operationally receive the analytical test strip. The LDSGCB includes a signal summation circuit (“SSC”) sub-block, a resistance-capacitance (RC) filter, and a single operational amplifier. The clock module and micro-controller are configured to generate phase-shifted square wave signals and output the phase-shifted square wave signals to the SSC. The SSC is configured to sum the phase-shifted square wave signals to generate a resultant summed-wave signal and output the resultant summed-wave signal to the RC filter. The RC filter is configured to filter harmonics from the resultant summed-wave signal thereby creating a reduced harmonic distortion signal.

Abstract translation: 用于测定体液样品中的分析物的分析测试条的手持式测试仪包括壳体，设置在壳体中的时钟模块，设置在壳体中的微控制器，低失真信号 设置在壳体中的发生电路块（“LDSGCB”）以及被配置为可操作地接收分析测试条的条形端口连接器。 LDSGCB包括信号求和电路（“SSC”）子块，电阻电容（RC）滤波器和单个运算放大器。 时钟模块和微控制器被配置为产生相移方波信号并将相移的方波信号输出到SSC。 SSC被配置为对相移的方波信号求和以产生合成的和波信号，并将所得的和波信号输出到RC滤波器。 RC滤波器被配置为从所得到的和波信号中滤除谐波，从而产生减小的谐波失真信号。

公开(公告)号：US20150073718A1

公开(公告)日：2015-03-12

申请号：US14023275

申请日：2013-09-10

Applicant: LifeScan Scotland Limited

Inventor： David ELDER ,  Tim Lloyd ,  Christian Forlani ,  Rossano Massari ,  Emanuele Pozzi

IPC: G01N33/49 ,  G01N27/06

CPC classification number: G01N33/49 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/7225 ,  A61B2560/0209 ,  A61B2562/0295 ,  G01N27/3273 ,  G01N27/3274

Abstract: A hand-held test meter includes a strip port connector to receive a test strip. A signal-measurement circuit applies a periodic voltage signal across a sample applied to the strip and detects a resulting current signal. The circuit provides data of the current signal at a digitizing frequency and a selected phase with respect to the voltage signal. A processor records one or more value(s) of the data and then alters the selected phase. Value(s) are thus recorded at each of a plurality of phases. The processor determines a phase difference of the current signal with respect to the voltage signal using the respective sets of value(s). A method for employing a test meter and a test strip is also disclosed, and includes measuring a respective plurality of points for each of a plurality of different measurement phases and determining a phase difference of a fluid sample therefrom.

Abstract translation: 手持测试仪包括用于接收测试条的条形端口连接器。 信号测量电路在施加到条上的样本上施加周期性电压信号，并检测结果电流信号。 该电路以数字化频率和相对于电压信号的选定相位提供电流信号的数据。 处理器记录一个或多个数据值，然后改变所选择的阶段。 因此，在多个相位中的每一个处记录值。 处理器使用相应的一组值来确定电流信号相对于电压信号的相位差。 还公开了一种采用测试仪和测试条的方法，包括测量多个不同测量阶段中的每一个的相应多个点，并确定流体样本的相位差。

公开(公告)号：US20140326614A1

公开(公告)日：2014-11-06

申请号：US13875487

申请日：2013-05-02

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Brian Guthrie ,  Tim Lloyd ,  Yeswanth Gadde ,  Alexander Strachan ,  David Elder ,  Rossano Massari ,  Christian Fortani

IPC: G01N27/30

CPC classification number: G01N27/307 ,  G01N27/3273 ,  G01N27/3274

Abstract: A portable analytical test meter is designed for use with an associated analytical test strip. A test-strip-receiving module receives the analytical test strip and is electrically connected to a dummy load calibration circuit block. That block is configured to provide a dummy magnitude correction and a dummy phase correction; and a memory block is configured to store the dummy magnitude correction and the dummy phase correction. A method for calibrating a portable analytical test meter for use with an analytical test strip includes determining a dummy magnitude correction and a dummy phase correction of the portable analytical test meter using a dummy load calibration circuit block of the portable analytical test meter. The dummy magnitude correction and the dummy phase correction are stored in a memory block of the portable analytical test meter. Using the stored dummy magnitude correction and stored dummy phase correction, an analyte is determined.

Abstract translation: 便携式分析测试仪设计用于与相关的分析测试条一起使用。 测试条接收模块接收分析测试条并且电连接到虚拟负载校准电路块。 该块被配置为提供虚拟幅度校正和伪相位校正; 并且存储块被配置为存储虚拟幅度校正和虚拟相位校正。 用于校准用于分析测试条的便携式分析测试仪的方法包括使用便携式分析测试仪的虚拟负载校准电路块来确定便携式分析测试仪的虚拟大小校正和虚拟相位校正。 虚拟大小校正和虚拟相位校正被存储在便携式分析测试仪的存储块中。 使用所存储的虚拟幅度校正和存储的虚拟相位校正，确定分析物。

公开(公告)号：US09442089B2

公开(公告)日：2016-09-13

申请号：US14138820

申请日：2013-12-23

Applicant: LifeScan Scotland Limited

Inventor： Rossano Massari ,  Emanuele Pozzi ,  Tim Lloyd ,  David Elder

IPC: G01N27/327 ,  G01N27/30 ,  G01N33/487

CPC classification number: G01N27/307 ,  G01N33/48785

Abstract: An analyte meter having a test strip port is configured to detect an inserted test strip using an unpowered grounded op amp while the analyte meter is in sleep mode. After a test strip is inserted and the meter is activated, the op amp is powered and provides the sample current for measuring an analyte concentration in the sample.

Abstract translation: 具有测试条端口的分析物计量器被配置为在分析物仪处于睡眠模式时使用未供电的接地运算放大器检测插入的测试条。 在插入测试条并且仪表被激活之后，运算放大器被供电并提供用于测量样品中分析物浓度的样品电流。

公开(公告)号：US09395319B2

公开(公告)日：2016-07-19

申请号：US13875487

申请日：2013-05-02

Applicant: LifeScan Scotland Limited

Inventor： Brian Guthrie ,  Tim Lloyd ,  Yeswanth Gadde ,  Alexander Strachan ,  David Elder ,  Rossano Massari ,  Christian Forlani

IPC: G01N27/30 ,  G01N27/327

CPC classification number: G01N27/307 ,  G01N27/3273 ,  G01N27/3274

Abstract: A portable analytical test meter is designed for use with an associated analytical test strip. A test-strip-receiving module receives the analytical test strip and is electrically connected to a dummy load calibration circuit block. That block is configured to provide a dummy magnitude correction and a dummy phase correction; and a memory block is configured to store the dummy magnitude correction and the dummy phase correction. A method for calibrating a portable analytical test meter for use with an analytical test strip includes determining a dummy magnitude correction and a dummy phase correction of the portable analytical test meter using a dummy load calibration circuit block of the portable analytical test meter. The dummy magnitude correction and the dummy phase correction are stored in a memory block of the portable analytical test meter. Using the stored dummy magnitude correction and stored dummy phase correction, an analyte is determined.

Abstract translation: 便携式分析测试仪设计用于与相关的分析测试条一起使用。 测试条接收模块接收分析测试条并且电连接到虚拟负载校准电路块。 该块被配置为提供虚拟幅度校正和伪相位校正; 并且存储块被配置为存储虚拟幅度校正和虚拟相位校正。 用于校准用于分析测试条的便携式分析测试仪的方法包括使用便携式分析测试仪的虚拟负载校准电路块来确定便携式分析测试仪的虚拟大小校正和虚拟相位校正。 虚拟大小校正和虚拟相位校正被存储在便携式分析测试仪的存储块中。 使用所存储的虚拟幅度校正和存储的虚拟相位校正，确定分析物。

公开(公告)号：US20140299483A1

公开(公告)日：2014-10-09

申请号：US13857280

申请日：2013-04-05

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Tim Lloyd ,  David McColl ,  Antony Smith ,  Brian Guthrie ,  David Elder ,  Rossano Massari ,  Christian Forlani

IPC: G01N27/327

CPC classification number: G01N27/3273 ,  G01N27/3274 ,  G01N27/3275

Abstract: An analyte meter having a test strip port is configured to transmit an electric signal through a received test strip with a sample. A pair of electrodes apply the electric signal and receive an electrical response from the test strip. A processing unit analyzes the electrical response and uses the response to determine an analyte level of the sample.

Abstract translation: 具有测试条端口的分析物计量器被配置为通过带有样品的接收的测试条来传输电信号。 一对电极施加电信号并从测试条接收电响应。 处理单元分析电响应并使用响应来确定样品的分析物水平。