公开(公告)号：MX9705404A

公开(公告)日：1997-10-31

申请号：MX9705404

申请日：1995-12-28

Applicant: UNIV TEMPLE ,  OF HIGYER EDUCATION

Inventor： SHAFFER THOMAS H ,  MILLER THOMAS F ,  WOLFSON MARLA R ,  FOUST RAYMOND III

IPC: G01N25/18 ,  A61B5/08 ,  A61B5/083 ,  A61B5/087 ,  A61M16/00 ,  F16K17/38 ,  G01N33/00 ,  G01N33/497 ,  A61B05/097

Abstract: La cantidad de líquido respirable eliminado de un mamífero por volatilizacion en los pulmones y/o transpiracion en la piel, se detecta midiendo la cantidad de saturacion del gas expiratorio con los vapores de líquido respirable; se evaluan valores de saturacion instantánea para determinar la cantidad de interaccion en los pulmones entre el líquido respirable y el gas respiratorio que fluye en el mismo, y para controlar operaciones seleccionadas de realimentacion para mantener la cantidad máxima posible de interaccion entre ellas; el nivel de saturacion de gas expiratorio también es empleado para optimizar parámetros de operacion de un sistema de recuperacion de líquido respirable a partir del gas expiratorio, directamente del paciente (24) o del gas del ventilador líquido (26); también se emplea el nivel de saturacion de gas expiratorio para efectuar estudios de capacidad funcional residual y para corregir errores en mediciones convencionales de capacidad funcional residual, efectuadas mientras un paciente está sometido a ventilacion parcial de líquido; cuando se emplea líquido respirable como un substituto de sangre, la cuantificacion de la pérdida de líquido respirable por volatilizacion y transpiracion ayuda a determinar cuándo reabastecer el líquido respirable en la corriente sanguínea; los vapores de una forma de líquido respirable, perfluorocarbono, se emplean para determinar la capacidad funcional residual de un pulmon de mamífero.

公开(公告)号：MX9704239A

公开(公告)日：1997-09-30

申请号：MX9704239

申请日：1996-10-02

Applicant: OTSUKA PHARMA CO LTD

Inventor： KUBO YASUHIRO ,  MORISAWA KATSUHIRO ,  ZASU YASUSHI ,  IKEGAMI EIJI ,  TSUTSUI KAZUNORI ,  HAMAO TAMOTSU ,  MORI MASAAKI ,  MARUYAMA TAKASHI

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/083 ,  A61B5/097 ,  A61B10/00 ,  G01N1/22 ,  G01N21/03 ,  G01N21/11 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/59 ,  G01N33/00 ,  G01N33/497 ,  G01N35/08 ,  A61B05/08 ,  A61B05/097

Abstract: Una curva de correccion se prepara graficando concentrados de 12CO2 y relaciones de concentracion 13CO2/12CO2 que son determinados en base a una curva de calibracion y absorbencias de 13CO2 y 12CO2 de muestras gaseosas que tienen la misma relacion de concentracion 13CO2/12CO2 pero diferentes concentraciones conocidas de 12CO2; una muestra gaseosa que contiene 13CO2 y 12CO2 como gases componentes se introduce en una celda y se mide espectrométricamente; una concentracion de 12CO2 de la muestra de ensayo gaseoso se determina mediante una medicion espectrométrica; se obtiene un valor de correccion de relacion de concentracion en base a la curva de correccion y la concentracion de 12CO2 de la muestra gaseosa de ensayo determina de este modo; una relacion de concentracion 13CO2/12CO2 se divide por el valor de correccion de relacion de concentracion obtenido de esta forma para corregir la relacion de concentracion 13CO2/12CO2; de este modo, se puede mejorar la precision de la medicion de las relaciones de concentracion de los gases componentes.

公开(公告)号：WO1992005738A1

公开(公告)日：1992-04-16

申请号：PCT/GB1991001708

申请日：1991-10-03

Applicant: LION LABORATORIES PLC ,  WILLIAMS, Paul, Michael

Inventor： LION LABORATORIES PLC

IPC: A61B05/097

CPC classification number: A61B5/0878 ,  A61B5/097 ,  G01N33/4972

Abstract: A mouthpiece for apparatus for detecting the presence of alcohol or drugs in the breath of a user is generally indicated at (10) and comprises a body (11) and filter insert (12). The body (11) includes a tube (13) and an open end (14) and a closed end (15) in which the breath inlet (16) is offset from the access of the tube (13). The filter insert (12) includes a perforate plate (21) which extends across the breath path to trap the majority of saliva or other contaminates. The size and number of the perforations (24) in the plate are selected so as to provide an overall cross-section which is equal to or greater than the smallest cross-section of the inlet (16).

Abstract translation: 用于检测使用者呼吸中的酒精或药物的存在的装置的接口口通常在（10）处指示并且包括主体（11）和过滤器插入件（12）。 主体（11）包括管（13）和开口端（14）和封闭端（15），呼吸入口（16）偏离管（13）的通道偏移。 过滤器插入件（12）包括穿过呼吸路径延伸以捕获大多数唾液或其它污染物的穿孔板（21）。 选择板中的穿孔（24）的尺寸和数量以提供等于或大于入口（16）的最小横截面的总横截面。

公开(公告)号：WO1996022052A1

公开(公告)日：1996-07-25

申请号：PCT/US1995016703

申请日：1995-12-28

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  SHAFFER, Thomas, H. ,  WOLFSON, Marla, R. ,  MILLER, Thomas, F. ,  FOUST, Raymond, III

IPC: A61B05/097

CPC classification number: G01N33/497 ,  A61M16/0051 ,  A61M16/0054 ,  A61M16/026 ,  A61M2202/0476 ,  G01N33/0049 ,  Y10S128/913

Abstract: The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration, is detected by measuring the amount of saturation of the expiratory gas by vapors of the breathable liquid. Instantaneous saturation values are employed to gauge the amount of interaction in the lungs between the breathable liquid and respiratory gas flowing therein, and to control selected feedback operations to maintain the maximum possible amount of interaction therebetween. The saturation level of expiratory gas is also employed to optimize operating parameters of a system for recovering the breathable liquid from the expiratory gas, directly from the patient (24), or from gas of liquid ventilator (26). The saturation level of expiratory gas is also employed to perform functional residual capacity studies and to correct to errors in conventional functional residual capacity measurements performed while a patient undergoes partial liquid ventilation. When breathable liquid is employed as a blood substitute, the quantification of the loss of the breathable liquid from volatilazition and transpiration helps to determine when to replenish the breathable liquid in the bloodstream. Vapors of one form of breathable liquid, perfluorocarbon, are employed to determine the functional residual capacity of a mammal's lung.

Abstract translation: 通过透气性液体的蒸汽测量呼气气体的饱和度来检测从哺乳动物通过肺中和/或通过皮肤蒸腾而挥发的透气液体的量。 使用瞬时饱和值来测量在其中流动的透气液体和呼吸气体之间的肺中的相互作用的量，并且控制所选择的反馈操作以保持其间的最大可能的相互作用量。 呼吸气体的饱和水平也用于优化用于从呼气气体直接从患者（24）或从液体通气机（26）的气体回收呼吸气体的系统的操作参数。 呼气气体的饱和水平也用于执行功能残余容量研究，并纠正在患者进行部分液体通气时进行的常规功能残余容量测量中的误差。 当使用透气液体作为血液替代品时，从挥发和蒸腾中量化透气液体的损失有助于确定何时补充血液中的透气液体。 使用一种透气性液体全氟化碳的蒸气来确定哺乳动物肺的功能残留能力。

公开(公告)号：WO1995018566A1

公开(公告)日：1995-07-13

申请号：PCT/US1995000172

申请日：1995-01-06

Applicant: PHILLIPS, Michael

IPC: A61B05/097

CPC classification number: G01N1/24 ,  A61B5/097 ,  G01N33/497 ,  G01N2001/248 ,  Y10S977/904

Abstract: Apparatus (10) which is highly portable and even hand-held is used to collect mammalian breath for chemical analysis and as a diagnostic tool for the physician.

Abstract translation: 高度便携，甚至手持的装置（10）用于收集哺乳动物呼吸进行化学分析，并作为医生的诊断工具。

公开(公告)号：WO1998008436A1

公开(公告)日：1998-03-05

申请号：PCT/FR1997001503

申请日：1997-08-19

Applicant: PLASTO S.A. ,  TRAN-VAN, Luc ,  TAVERNIER, Laurent

Inventor： PLASTO S.A.

IPC: A61B05/097

CPC classification number: A61B5/097 ,  G01N33/4972

Abstract: The invention concerns a removable hygienic mouthpiece of the type comprising a mouthpiece (1) capable of being adapted on an apparatus for controlling expired air and comprising an inlet connection piece (4) and an outlet connection piece (7) separated by a baffle (10, 11) and it is characterised in that the baffle (10, 11) comprises a foam with open cells and in that the mouthpiece (1) is made of materials treated against microbes. The invention is useful in particular, associated with a breathalyser, for measuring the amount of alcohol in a subject.

Abstract translation: 本发明涉及一种可移除的卫生接口，其包括一个能够适应于用于控制呼出空气的设备的接口管（1），并且包括入口连接件（4）和由挡板（10）隔开的出口连接件（7） ，11），其特征在于，挡板（10,11）包括具有开孔的泡沫，并且所述接口（1）由对微生物进行处理的材料制成。 本发明特别用于与呼吸机相关联，用于测量受试者中的酒精量。

公开(公告)号：WO1995026680A1

公开(公告)日：1995-10-12

申请号：PCT/CA1995000179

申请日：1995-03-31

Applicant: UNIVERSITE LAVAL

Inventor： UNIVERSITE LAVAL ,  SERIES, Frederic ,  MARC, Isabelle

IPC: A61B05/097

CPC classification number: A61B5/083 ,  A61B5/7242 ,  A61B5/7264

Abstract: Inspiratory flow limitation (IFL) is involved in the pathophysiology of sleep-related breathing disorders. Since the definition of flow-limited cycle is based on a dissociation between flow and respiratory efforts, identification of IFL requires upper airway or intrathoracic pressure measurements. We examined the feasability and accuracy of the analysis of the flow-volume loop of a tidal breath in identifying IFL. The tidal volume was obtained by integration of the instantaneous airflow signal, and the flow-volume loop was reconstructed for each breathing cycle by plotting the instantaneous flow and the tidal volume. The instantaneous inspiratory and expiratory flows were measured at a 50 % of the respective (inspiratory or expiratory) portion of the tidal volume, and a breath-by-breath analysis of the mid tidal volume flow ratio (I/E ratio) was obtained. There was a positive significant relationship between I/E ratio and VImax (maximal inspiratory volume) for flow-limited breathing (correlation coefficient range: 0.25-0.54). With a lower limit of the normal I/E ratio threshold of 0.97, the sensitivity and specificity of the method were both 76 %. Patients having a I/E ratio lower than 0.97 to 1 are classified as suffering IFL. Therefore, the present invention relates to the above-described non-invasive method which is applicable in the evaluation IFL and to an apparatus measuring I/E ratio and correcting IFL.

Abstract translation: 吸入流量限制（IFL）涉及睡眠相关呼吸障碍的病理生理学。 由于流动限制循环的定义是基于流动和呼吸作用之间的解离，因此识别IFL需要上呼吸道或胸腔内压力测量。 我们检查了在识别IFL时潮气呼吸的流量回路分析的可行性和准确性。 通过整合瞬时气流信号获得潮气量，并通过绘制瞬时流量和潮气量来为每个呼吸循环重建流量循环。 在潮气量的相应（吸气或呼气）部分的50％处测量瞬时吸气和呼气流量，并获得中等潮气量流量比（I / E比）的呼吸分析。 流量限制呼吸（相关系数范围：0.25-0.54）的I / E比与VImax（最大吸气体积）之间存在正相关关系。 正常I / E比阈值下限为0.97，方法灵敏度和特异度均为76％。 I / E比低于0.97比1的患者被归类为患有IFL。 因此，本发明涉及可用于评估IFL的上述非侵入性方法以及测量I / E比率和校正IFL的装置。

公开(公告)号：WO1994018885A1

公开(公告)日：1994-09-01

申请号：PCT/US1994002141

申请日：1994-02-23

Applicant: MARTEK BIOSCIENCES CORPORATION

Inventor： MARTEK BIOSCIENCES CORPORATION ,  DELENTE, Jacques, J.

IPC: A61B05/097

CPC classification number: A61B5/097 ,  Y10T436/20

Abstract: A simplified, user-friendly method and apparatus for collecting and storing a human breath sample and for detecting and indicating whether the stored breath sample is a true alveolar sample. The invention includes in one embodiment thereof a preferably transparent container (1) and a breath delivery device (6) for directing a subject's breath into the container (1). A closure device (5) is provided for accomodating the insertion of the breath delivery device (6) into the container (1) and for substantially sealing the container (1). A detector (12) is provided for being positioned within the sealed container (1) for detecting and indicating to an observer whether the breath sample stored in the container (1) is a true alveolar sample.

Abstract translation: 一种用于收集和存储人类呼吸样本并用于检测和指示储存的呼吸样品是否为真正肺泡样品的简化的，用户友好的方法和装置。 本发明在其一个实施方案中包括优选透明的容器（1）和用于将受试者的呼吸引导到容器（1）中的呼吸输送装置（6）。 提供闭合装置（5），用于容纳将呼吸输送装置（6）插入容器（1）中并基本上密封容器（1）。 提供检测器（12），用于定位在密封容器（1）内，用于检测并向观察者指示储存在容器（1）中的呼吸样品是真正的肺泡样品。

公开(公告)号：WO1997043952A1

公开(公告)日：1997-11-27

申请号：PCT/EP1997002493

申请日：1997-05-15

Applicant: KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG ,  GUTTMANN, Josef ,  MÜLLER, Wolfgang ,  BRAUN, Günther

Inventor： KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG

IPC: A61B05/097

CPC classification number: A61B5/0836 ,  A61B5/097 ,  A61M16/085 ,  A61M16/106 ,  A61M16/1065 ,  A61M16/107

Abstract: A process and a device (1) are used to collect at least low concentrations of volatile substances in a patient's exhaled respiratory gas. The collector has a respiratory gas channel and a sample gas channel (20, 21) branching off from it and is designed to pre-concentrate volatile substances in low concentration taken from the respiratory gas. To this end, the sample gas channel (20, 21) includes a collector (11) for the samples branched off from the respiratory gas to be examined. Upstream of the sample gas channel (20, 21) there is a changeover valve (7) which is connected to a control device (13) to switch over from the respiratory gas channel to the sample gas channel and to take alveolar gas from several breaths to the collector (11) for the cumulative pre-concentration of the volatile substances. A sample gas conveyor (12) is connected to the sample gas channel (20, 21).

Abstract translation: 一种方法和装置（1）是低浓度的，用于收集患者，挥发性物质的呼气的呼吸气体中至少含有。 所述收集装置包括呼吸气体供应并从其样本气体通道分支（20，21）和用于取出的样品的预浓缩，所形成的呼吸气体中的低浓度的挥发性物质。 样品气体通道（20，21）向其中包括收集装置包含在从呼吸气体的呼吸气体样品的支化的（11）要检查的物质。 布置在样品气体通道（20，21）的上游是一个切换阀（7）连接到控制装置（13），用于从所述呼吸气体引导到样品气体通道（20，21）的开关和用于提供几个呼吸的肺泡到收集装置（11） 被连接到挥发性物质的累积预浓缩。 到样品气体通道（20，21）是连接的样品气体输送装置（12）。

公开(公告)号：WO1995025462A1

公开(公告)日：1995-09-28

申请号：PCT/FR1995000346

申请日：1995-03-21

Applicant: INBIOMED INTERNATIONAL ,  GUILLUY, Roger

Inventor： INBIOMED INTERNATIONAL

IPC: A61B05/097

CPC classification number: A61B5/097 ,  G01N33/497 ,  G01N2001/1056

Abstract: In its raised position, a cap (3) enables air blown in through a cannula (6) to fill the inner space of a tube (1) until an indicator (11, 12 or 13) shows that the volume is sufficient. The cannula (6) is pulled out by the user so that a plug (7) engages a neck (3c) and seals the inlet of a duct (10). The cap (3) is then tightly screwed on to seal the air sample within the tube (1).

Abstract translation: 在其升高位置，盖（3）使得通过套管（6）吹入的空气填充管（1）的内部空间，直到指示器（11,12或13）显示体积足够。 套管（6）被用户拉出，使得塞子（7）接合颈部（3c）并密封管道（10）的入口。 然后将盖（3）紧紧地拧紧以密封管（1）内的空气样品。