公开(公告)号：CA2745414A1

公开(公告)日：2010-06-10

申请号：CA2745414

申请日：2009-11-30

Applicant: MEDTRONIC INC

Inventor： BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  LUO LIAN L ,  KRAMER JOHN

IPC: A61K9/22 ,  A61K47/34

Abstract: Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.

公开(公告)号：ES2515195T3

公开(公告)日：2014-10-29

申请号：ES09775411

申请日：2009-11-30

Applicant: MEDTRONIC INC

Inventor： BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  LUO LIAN L ,  KRAMER JOHN

IPC: A61K31/4168 ,  A61K9/00 ,  A61K9/22 ,  A61K31/445 ,  A61K47/34

Abstract: Un medicamento depot fluido que comprende: un poliéster poli(carbonato de trimetileno) biodegradable con grupos terminales protegidos con un alcohol primario; y un agente terapéutico que alivia el dolor post-operatorio seleccionado del grupo que consiste en bupivacaína o clonidina.

公开(公告)号：WO2010065456A4

公开(公告)日：2011-03-31

申请号：PCT/US2009066107

申请日：2009-11-30

Applicant: MEDTRONIC INC ,  BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  LUO LIAN L ,  KRAMER JOHN

Inventor： BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  LUO LIAN L ,  KRAMER JOHN

IPC: A61K9/22 ,  A61K47/34

CPC classification number: A61K9/0024 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34

Abstract: Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.

Abstract translation: 描述了可流动药剂库。 可流动的药物贮库包括聚酯，例如聚乳酸或用伯醇封端的聚（碳酸三亚甲基酯）和缓痛治疗剂如手术后疼痛缓解治疗剂。 还描述了制造和使用它们的方法。

公开(公告)号：WO2010065456A3

公开(公告)日：2011-01-27

申请号：PCT/US2009066107

申请日：2009-11-30

Applicant: MEDTRONIC INC ,  BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  LUO LIAN L ,  KRAMER JOHN

Inventor： BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  LUO LIAN L ,  KRAMER JOHN

IPC: A61K9/22 ,  A61K47/34

CPC classification number: A61K9/0024 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34

Abstract: Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.

Abstract translation: 描述了可流动的配药仓库。 可流动的药物贮存库包括用伯醇封端的聚酯，例如聚乳酸或聚（碳酸三亚甲基酯）和缓解疼痛的治疗剂，例如手术后疼痛缓解治疗剂。 还描述了制造和使用其的方法。