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    Method for hermetically sealing microchip reservoir devices
    1.
    发明专利
    Method for hermetically sealing microchip reservoir devices 审中-公开
    用于密封微孔储存器件的方法

    公开(公告)号：JP2008284379A

    公开(公告)日：2008-11-27

    申请号：JP2008157288

    申请日：2008-06-16

    Applicant: Microchips Inc ,  マイクロチップス・インコーポレーテッド

    Inventor： UHLAND SCOTT A ,  POLITO BENJAMIN F ,  HERMAN STEPHEN J ,  SANTINI JOHN T JR ,  MALONEY JOHN M

    IPC: A61J3/07 ,  B81C3/00 ,  A61K9/00 ,  A61K9/22 ,  B23K1/06 ,  B23K26/00 ,  B81B1/00 ,  H01L27/14

    CPC classification number: A61K9/0097

    Abstract: PROBLEM TO BE SOLVED: To provide methods for hermetically sealing reservoirs of microchip devices, and hermetically sealing the substrate assemblies in a hermetic packaging structure. SOLUTION: The method comprises: (1) the step of providing a primary substrate 12 having a front side and a back side, the substrates comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; and (2) the step of providing a hermetic sealing substrate 18 having a surface composed of one or more hermetic sealing materials. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供用于密封微芯片装置的储存器的方法，并将密封基板组件气密地密封在密封包装结构中。 解决方案：该方法包括：（1）提供具有前侧和后侧的主基板12的步骤，该基板包括位于前侧和后侧之间的多个储存器，每个储存器被加载 具有用于控制释放或暴露的分子或二次装置，所述储存器具有至少一个需要密封的开口，所述主基底包括一个或多个密封材料; 和（2）提供具有由一种或多种密封材料构成的表面的气密密封基材18的步骤。 版权所有（C）2009，JPO＆INPIT

    Thermally activated microchip chemical delivery device
    3.
    发明专利
    Thermally activated microchip chemical delivery device 审中-公开
    热活化微型化学品交付装置

    公开(公告)号：JP2007283117A

    公开(公告)日：2007-11-01

    申请号：JP2007160766

    申请日：2007-06-18

    Applicant: Microchips Inc ,  マイクロチップス・インコーポレーテッド

    Inventor： SANTINI JOHN T JR ,  CIMA MICHAEL J ,  UHLAND SCOTT A

    IPC: A61M37/00 ,  A61K9/00 ,  A61K9/22 ,  B01L3/00

    CPC classification number: B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    Abstract: PROBLEM TO BE SOLVED: To provide a multi-well type delivery device for different molecules, not requiring the existence of chemical substance and electrolyte, and to provide a multi-well type delivery device, not requiring chemical substance and a conductive reservoir cap, or actively releasing different molecules, not directing application of electric potential. SOLUTION: This microchip device for releasing molecules includes: a substrate including a release system containing released molecules; a plurality of reservoirs in the substrate; reservoir caps located on the respective reservoirs or in the respective reservoirs to cover the release system; and a heating means for heating the release system to increase the pressure in the reservoirs to burst the reservoir caps. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供不需要化学物质和电解质的存在的不同分子的多孔型输送装置，并且提供不需要化学物质和导电储存器的多孔型输送装置 帽或主动释放不同的分子，而不是引导电位的应用。 解决方案：用于释放分子的微芯片器件包括：包含含有释放分子的释放系统的衬底; 在所述基板中的多个储存器; 储存器盖位于相应的储存器或相应储存器中以覆盖释放系统; 以及用于加热释放系统以增加储存器中的压力以使储存器盖突然爆裂的加热装置。 版权所有（C）2008，JPO＆INPIT

    Methods for hermetically sealing microchip reservoir devices
    4.
    发明专利
    Methods for hermetically sealing microchip reservoir devices 未知

    公开(公告)号：AU2002361545B2

    公开(公告)日：2007-03-15

    申请号：AU2002361545

    申请日：2002-06-28

    Applicant: MICROCHIPS INC

    Inventor： POLITO BENJAMIN F ,  HERMAN STEPHEN J ,  UHLAND SCOTT A ,  SANTINI JOHN T JR

    IPC: B81C3/00 ,  A61K9/00 ,  A61K9/22 ,  B23K1/06 ,  B23K26/00 ,  B81B1/00 ,  H01L27/14

    Abstract: Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

    THERMALLY-ACTIVATED MICROCHIP CHEMICAL DELIVERY DEVICES
    6.
    发明专利
    THERMALLY-ACTIVATED MICROCHIP CHEMICAL DELIVERY DEVICES 未知

    公开(公告)号：CA2381951A1

    公开(公告)日：2001-02-22

    申请号：CA2381951

    申请日：2000-08-11

    Applicant: MICROCHIPS INC

    Inventor： SANTINI JOHN T JR ,  CIMA MICHAEL J ,  UHLAND SCOTT A

    IPC: A61K9/00 ,  A61K9/22 ,  B01L3/00 ,  A61F13/00 ,  A61N1/30

    Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferr ed embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phas e change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

    MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS
    7.
    发明专利
    MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 未知

    公开(公告)号：CA2577709C

    公开(公告)日：2013-04-16

    申请号：CA2577709

    申请日：2005-09-01

    Applicant: MICROCHIPS INC

    Inventor： SANTINI JOHN T JR ,  SBIAA ZOUHAIR ,  COPPETA JONATHAN R ,  UHLAND SCOTT A ,  SHEPPARD NORMAN F JR

    IPC: B01L3/00 ,  A61K9/00 ,  A61M37/00

    Abstract: Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

    Controlled release device and method
    10.
    发明专利
    Controlled release device and method 未知

    公开(公告)号：AU2003303288B2

    公开(公告)日：2006-12-07

    申请号：AU2003303288

    申请日：2003-08-15

    Applicant: MICROCHIPS INC

    Inventor： SHEPPARD NORMAN F JR ,  POLITO BENJAMIN F ,  HERMAN STEPHEN J ,  UHLAND SCOTT A ,  MALONEY JOHN M ,  YOMTOV BARRY M

    IPC: A61K9/00 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/042 ,  A61M5/14 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32

    Abstract: Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

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