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    MICROCHIP RESERVOIR DEVICES AND FACILITATED CORROSION OF ELECTRODES
    6.
    发明申请
    MICROCHIP RESERVOIR DEVICES AND FACILITATED CORROSION OF ELECTRODES 审中-公开
    微电极储存器件和电极的腐蚀性腐蚀

    公开(公告)号：WO0230401A3

    公开(公告)日：2003-01-16

    申请号：PCT/US0142698

    申请日：2001-10-11

    Applicant: MICROCHIPS INC

    Inventor： SHEPPARD NORMAN F JR ,  FEAKES CHRISTINA M ,  SANTINI JOHN T JR

    IPC: A61K9/00 ,  A61K9/22

    CPC classification number: A61K9/0024 ,  A61K9/0009 ,  A61K9/0097 ,  A61M5/14276 ,  A61M2205/0244

    Abstract: Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, through the electrochemical cell, to the primary electrode. In a preferred embodiment, the primary electrode is metal and comprises a reservoir cap of a microchip device for the release of molecules or exposure of device reservoir contents. The potential preferably is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode. Also, the minimum potential preferably is effectively cathodic to be below the value where redeposition of metal ions on the metal electrode can substantially occur, thereby corroding the metal electrode.

    Abstract translation: 提供了用于增强生物相容性流体中的电极腐蚀的方法和装置。 该方法包括（1）将主电极和对电极放置在导电生物相容性流体中以形成电化学电池; 和（2）通过电化学电池将时变电位施加到初级电极。 在优选实施例中，主电极是金属并且包括用于释放分子的微芯片装置的储存器盖或装置储存器内容物的暴露。 该电位优选的特征在于具有有效地阳极以满足或超过初级电极的腐蚀电位的最大电位的波形。 此外，最小电位优选有效地为阴极，低于金属电极上的金属离子可以基本上发生再沉积，从而腐蚀金属电极的值。

    MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS
    7.
    发明专利
    MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 未知

    公开(公告)号：CA2577709C

    公开(公告)日：2013-04-16

    申请号：CA2577709

    申请日：2005-09-01

    Applicant: MICROCHIPS INC

    Inventor： SANTINI JOHN T JR ,  SBIAA ZOUHAIR ,  COPPETA JONATHAN R ,  UHLAND SCOTT A ,  SHEPPARD NORMAN F JR

    IPC: B01L3/00 ,  A61K9/00 ,  A61M37/00

    Abstract: Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

    8.
    发明专利
    未知

    公开(公告)号：DE602005013253D1

    公开(公告)日：2009-04-23

    申请号：DE602005013253

    申请日：2005-09-01

    Applicant: MICROCHIPS INC

    Inventor： SANTINI JOHN T ,  SBIAA ZOUHAIR ,  COPPETA JONATHAN R ,  UHLAND SCOTT ,  SHEPPARD NORMAN F JR

    IPC: B01L3/00 ,  A61K9/00 ,  A61M37/00

    Abstract: Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

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