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    Controlled release device and method
    6.
    发明专利
    Controlled release device and method 未知

    公开(公告)号：AU2003303288B2

    公开(公告)日：2006-12-07

    申请号：AU2003303288

    申请日：2003-08-15

    Applicant: MICROCHIPS INC

    Inventor： SHEPPARD NORMAN F JR ,  POLITO BENJAMIN F ,  HERMAN STEPHEN J ,  UHLAND SCOTT A ,  MALONEY JOHN M ,  YOMTOV BARRY M

    IPC: A61K9/00 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/042 ,  A61M5/14 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32

    Abstract: Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

    CONTROLLED RELEASE DEVICE AND METHOD
    8.
    发明申请
    CONTROLLED RELEASE DEVICE AND METHOD 审中-公开
    控制释放装置和方法

    公开(公告)号：WO2004071487A3

    公开(公告)日：2004-09-30

    申请号：PCT/US0325774

    申请日：2003-08-15

    Applicant: MICROCHIPS INC

    Inventor： UHLAND SCOTT A ,  POLITO BENJAMIN F ,  MALONEY JOHN M ,  SHEPPARD NORMAN F JR ,  HERMAN STEPHEN J ,  YOMTOV BARRY M

    IPC: A61B5/00 ,  A61B5/0215 ,  A61B5/042 ,  A61K9/00 ,  A61M5/14 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32

    CPC classification number: A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

    Abstract: Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

    Abstract translation: 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 在一个实施方案中，将控制释放系统结合到可植入药物递送装置中。

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