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1.发明授权Volume metering capillary gap device for applying a liquid sample onto a reactive surface 失效用于将液体样品应用于反应性表面的体积计量毛细管孔装置
公开(公告)号：EP0215419B1
公开(公告)日：1991-05-15
申请号：EP86112429.5
申请日：1986-09-08
Applicant: MILES INC.
Inventor： Blatt, Joel M. , Heiland, Robert , Morris, James R. , Pugh, Jerry T. , Wogoman, Frank W.
CPC classification number: B01L3/502738 , B01L3/5023 , B01L3/502746 , B01L2200/0605 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B29C65/08 , B29C66/1122 , B29C66/3022 , B29C66/543 , B29L2031/756
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公开(公告)号：EP0308770A3
公开(公告)日：1990-05-16
申请号：EP88114912.4
申请日：1988-09-13
Applicant: MILES INC.
Inventor： DeSimone, Joseph P. , Heiland, Robert J. , Moulton, Joseph L. , Purcell, D. Glenn , Pugh, Jerry T.
CPC classification number: G01N33/521 , G01N21/8483
Abstract: A quantitative measuring instrument includes a casing with a cavity for a reagent strip handling mechanism. The mechanism includes a slide with a resiliently biased toggle member for providing snap action of the slide between an open, reagent strip loading position and a closed, quantitative measuring position. A light seal is mounted on the toggle member that engages each reagent strip in the closed position of the slide. In a first, alternative embodiment of the instrument, the slide mechanism includes a cam arm that engages cam surfaces on the instrument raising the cam arm to an open, reagent strip loading position from a closed, reagent strip holding position. In this embodiment the slide can be removed from the instrument and cleaned. In a second alternative embodiment the slide includes a first detent corresponding to a closed position of the slide and a second detent corresponding to an open position. A pair of spring fingers are mounted in the cavity of the instrument casing. One of the spring fingers engages the first detent in the closed position and the second spring finger engages the second detent in the open position providing resistance that defines the two positions. The slide in this embodiment can also be removed and cleaned.
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3.发明公开Volume metering capillary gap device for applying a liquid sample onto a reactive surface 失效用于将液体样品应用于反应性表面的体积计量毛细管孔装置
公开(公告)号：EP0215419A3
公开(公告)日：1989-04-19
申请号：EP86112429.5
申请日：1986-09-08
Applicant: MILES INC.
Inventor： Blatt, Joel M. , Heiland, Robert , Morris, James R. , Pugh, Jerry T. , Wogoman, Frank W.
CPC classification number: B01L3/502738 , B01L3/5023 , B01L3/502746 , B01L2200/0605 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B29C65/08 , B29C66/1122 , B29C66/3022 , B29C66/543 , B29L2031/756
Abstract: A method for volume metering of a liquid sample onto a reactive surface and a flow metering capillary device for controlled fluid flow comprising two opposing surface areas spaced apart throughout a capillary zone of intended liquid transport at a distance no greater than that which will maintain a capillary flow of liquid introduced therebetween, means to permit Introduction of a test specimen between these surfaces, there being formed between said opposing surfaces an overflow channel and an overflow chamber which draws any excess liquid from the means for introducing the liquid between the surfaces.
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4.发明公开Apparatus for measuring nonspecular reflected light 失效Vorrichtung zur Messung nichtspekularen reflektierten Lichts。
公开(公告)号：EP0125340A2
公开(公告)日：1984-11-21
申请号：EP83110396.5
申请日：1983-10-19
Applicant: MILES INC.
Inventor： Brunsting, Albert , Hernicz, Ralph S. , Pugh, Jerry T.
CPC classification number: G01N21/474 , G01N2021/478
Abstract: Reflectance apparatus is disclosed for obtaining measurement of nonspecular reflected light in which one or more light sources and one or more detectors are mounted together on the same plane surface in close proximity to each other at an angle (φ) from the normal to the surface of the specimen holder. Angle (φ) is selected such that the specular reflection at the surface of the specimen is insignificant compared to the minimum diffused reflection expected from the specimen.
Abstract translation: 公开了一种用于获得非特异性反射光的测量的反射装置，其中一个或多个光源和一个或多个检测器以相对于彼此的法线表面的角度（phi）彼此靠近地安装在同一平面上， 样品架。 角度（phi）被选择为使得与样本预期的最小扩散反射相比，样品表面的镜面反射是不显着的。
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公开(公告)号：EP0308770A2
公开(公告)日：1989-03-29
申请号：EP88114912.4
申请日：1988-09-13
Applicant: MILES INC.
Inventor： DeSimone, Joseph P. , Heiland, Robert J. , Moulton, Joseph L. , Purcell, D. Glenn , Pugh, Jerry T.
CPC classification number: G01N33/521 , G01N21/8483
Abstract: A quantitative measuring instrument includes a casing with a cavity for a reagent strip handling mechanism. The mechanism includes a slide with a resiliently biased toggle member for providing snap action of the slide between an open, reagent strip loading position and a closed, quantitative measuring position. A light seal is mounted on the toggle member that engages each reagent strip in the closed position of the slide. In a first, alternative embodiment of the instrument, the slide mechanism includes a cam arm that engages cam surfaces on the instrument raising the cam arm to an open, reagent strip loading position from a closed, reagent strip holding position. In this embodiment the slide can be removed from the instrument and cleaned. In a second alternative embodiment the slide includes a first detent corresponding to a closed position of the slide and a second detent corresponding to an open position. A pair of spring fingers are mounted in the cavity of the instrument casing. One of the spring fingers engages the first detent in the closed position and the second spring finger engages the second detent in the open position providing resistance that defines the two positions. The slide in this embodiment can also be removed and cleaned.
Abstract translation: 定量测量仪器包括具有用于试剂条处理机构的空腔的壳体。 该机构包括具有弹性偏置的肘节件的滑块，用于在打开的试剂条装载位置和闭合的定量测量位置之间提供滑动件的快动作用。 轻型密封件安装在跷跷板构件上，其在滑块的关闭位置接合每个试剂条。 在仪器的第一替代实施例中，滑动机构包括凸轮臂，凸轮臂接合仪器上的凸轮表面，凸轮臂将凸轮臂升高到打开的试剂条装载位置，该试剂条装载位置处于关闭的试剂条保持位置。 在该实施例中，滑块可以从仪器中取出并进行清洁。 在第二替代实施例中，滑块包括对应于滑块的关闭位置的第一制动器和对应于打开位置的第二制动器。 一对弹簧指状件安装在仪器壳体的空腔中。 弹簧指中的一个在闭合位置接合第一棘爪，而第二弹簧指在接近打开位置的第二棘爪处接合，从而提供限定两个位置的阻力。 该实施例中的滑块也可以被移除和清洁。
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Patent Agency Ranking
公开(公告)号：EP0131194B1
公开(公告)日：1988-05-11
申请号：EP84107299.4
申请日：1984-06-26
Applicant: MILES INC.
Inventor： Boger, David L. , Johnson, Leighton C. , Pugh, Jerry T.
IPC: G01N33/52 , G01N33/548
CPC classification number: G01N33/523 , Y10S435/805
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公开(公告)号：EP0245703A2
公开(公告)日：1987-11-19
申请号：EP87106226.1
申请日：1987-04-29
Applicant: MILES INC.
Inventor： Brenneman, Allen J. , Buck, Harvey B. Jr. , Pugh, Jerry T. , Robertson, Steven P.
CPC classification number: B04B7/08 , B04B5/0407
Abstract: Separation device and method for the fractionation and separation of finely divided solid particulate material suspended in a liquid are disclosed. The separation device comprises. upper and lower portions which are joined together to form an inner cavity retaining liquid and a capillary gap which extends outwardly radially from said cavity. During rotation solid particles present in the suspending liquid pass outwardly along and/or become entrapped in the capillary gap(s).
Abstract translation: 公开了用于分离和分离悬浮在液体中的细碎固体颗粒材料的分离装置和方法。 分离装置包括连接在一起以形成内腔保持液体的上部和下部以及从所述腔向外径向延伸的毛细管间隙。 在旋转期间，存在于悬浮液中的固体颗粒沿着和/或被截留在毛细管间隙中向外通过。
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公开(公告)号：EP0245703B1
公开(公告)日：1990-01-10
申请号：EP87106226.1
申请日：1987-04-29
Applicant: MILES INC.
Inventor： Brenneman, Allen J. , Buck, Harvey B. Jr. , Pugh, Jerry T. , Robertson, Steven P.
CPC classification number: B04B7/08 , B04B5/0407
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公开(公告)号：EP0128422B1
公开(公告)日：1989-01-18
申请号：EP84105914.0
申请日：1984-05-24
Applicant: MILES INC.
Inventor： Boger, David L. , Pugh, Jerry T. , Zuidema, Jack L.
CPC classification number: B01L3/5085 , G01N31/22 , Y10S435/805
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公开(公告)号：EP0131194A2
公开(公告)日：1985-01-16
申请号：EP84107299.4
申请日：1984-06-26
Applicant: MILES INC.
Inventor： Boger, David L. , Johnson, Leighton C. , Pugh, Jerry T.
IPC: G01N33/52 , G01N33/548
CPC classification number: G01N33/523 , Y10S435/805
Abstract: A multiple profile reagent card for simultaneously or sequentially performing multiple analyses of analyte is formed by applying ribbons of reagent impregnated matrix material parallel to each other on a substrate and then removing portions of at least the matrix material to create separate matrices along each ribbon of matrix material. The multiple profile reagent card facilitates automatic processing of immunochemical, diagnostic and/or serological tests.
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