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4 records (took 0.038 seconds)

    1.
    发明专利
    未知

    公开(公告)号：NO823658L

    公开(公告)日：1983-05-05

    申请号：NO823658

    申请日：1982-11-03

    Applicant: MILES LAB

    Inventor： ATKINSON DAVID C ,  CARRICO ROBERT JOSEPF ,  MORRIS DAVID L

    IPC: G01N33/78 ,  G01N

    Abstract: An improved immunoassay method, reagent means, and test kit for determining an iodothyronine, e.g., thyroxine (T-4), in a biological fluid, usually serum or piasma, wherein fenclofenac and related phenylacetic acids, or salts thereof, are employed as novel blocking agents for the binding of iodothyronines to thyroxine binding protein (TBP). The present invention is particularly advantageous as applied to homogeneous competitive binding iodothyronine immunoassays wherein a spectrophotometric response is generated in the assay reaction mixture at a wavelength greater than about 300 nm, the blocking agents of the present invention having been found to have no substantial absorbance at wavelengths above 300 nm. Such homogeneous immunoassays include those which employ labels such as fluorescers, enzyme substrates, enzyme prosthetic groups, enzymes, and enzyme inhibitors.

    3.
    发明专利
    未知

    公开(公告)号：NO823657L

    公开(公告)日：1983-05-05

    申请号：NO823657

    申请日：1982-11-03

    Applicant: MILES LAB

    Inventor： ALBARELLA JAMES PAUL ,  CARRICO ROBERT JOSEPF ,  LI THOMAS M

    IPC: A61K49/04 ,  G01N33/78 ,  G01N

    Abstract: Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates.

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