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公开(公告)号：JPS63270637A
公开(公告)日：1988-11-08
申请号：JP10328787
申请日：1987-04-28
Applicant: MITSUI TOATSU CHEMICALS
Inventor： ONO HIROSHI , KASUGA TAKAHARU , HEN PARAA , KIYONO SHINJI
Abstract: PURPOSE:To efficiently obtain the titled compound useful as a food additive, etc., in high purity by simple operation, by using isopropyl acetate as an extracting solvent in separating lactic acid from a solution containing the lactic acid by extraction. CONSTITUTION:Isopropyl acetate is used as an extracting solvent to separate and obtain lactic acid from a lactic acid-containing aqueous solution. The extracting operation is carried out normally at 10-80 deg.C, preferably at 15-45 deg.C. The amount of the isopropyl acetate used varies with the concentration of the lactic acid or extraction ratio in the extracting operation; however, a volume of 1-50 times based on water in the lactic acid-containing aqueous solution is normally preferred. Operation temperature in separating and recovering the lactic acid from the lactic acid-containing isopropyl acetate after the extraction is normally 10-80 deg.C, especially preferably 15-45 deg.C.
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公开(公告)号：JPH01203346A
公开(公告)日：1989-08-16
申请号：JP2653388
申请日：1988-02-09
Applicant: MITSUI TOATSU CHEMICALS
Inventor： HEN PARAA , FUJITA YOSHIHIRO , ONO HIROSHI
Abstract: PURPOSE:To readily and efficiently obtain the present compound in high selectivity at a low temperature under a low pressure, by reacting vinyl chloride with CO and H2 in the presence of a catalyst, such as a rhodium compound and trivalent organic phosphorus compound, coexisting with an organic acid and base as a cocatalyst. CONSTITUTION:Vinyl chloride is reacted with CO and H2 in the presence of a catalyst of a rhodium compound, such as hexadecanylhexarhodium, and a trivalent organic phosphorus compound, such as triphenylphosphine, or an oxide thereof coexisting with an organic acid, such as phthalic acid, and a base, such as NaOH, further in the presence of preferably water, preferably in a solvent, such as toluene, at 10-150 deg.C under 10-300kg/cm G pressure to afford the aimed compound useful as an intermediate for cosmetics and agricultural chemicals, etc. Furthermore, high activity can be stably maintained for a long period without accumulating by-products in a reactor and loss of rhodium can be reduced without requiring frequent regeneration of the catalyst, etc.
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公开(公告)号：JPS63270638A
公开(公告)日：1988-11-08
申请号：JP10439187
申请日：1987-04-30
Applicant: MITSUI TOATSU CHEMICALS
Inventor： ONO HIROSHI , KASUGA TAKAHARU , HEN PARAA , IWAMOTO EIJU
Abstract: PURPOSE:To improve quality in excellent energy efficiency by a simple device in obtaining the titled compound useful as industrial chemicals, etc., by hydrolyzing 2-chloropropionic acid, by carrying out the hydrolysis in the presence of specific amounts of calcium hydroxide and water. CONSTITUTION:2-Chloropropionic acid as a raw material is hydrolyzed in the presence of 0.4-0.8mol., preferably 0.48-0.52mol. based on 1mol. raw material of calcium hydroxide and 30-150g water at 80-200 deg.C, preferably 120-160 deg.C for 10min-12hr to give the aimed compound. In the reaction, calcium oxide can be used instead of calcium hydroxide. The hydrolysis is preferably done thoroughly until unreacted 2-chloropropionic is not detected.
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公开(公告)号：JP2505456B2
公开(公告)日：1996-06-12
申请号：JP10328787
申请日：1987-04-28
Applicant: MITSUI TOATSU CHEMICALS
Inventor： ONO HIROSHI , KASUGA TAKAHARU , HEN PARAA , KYONO SHINJI
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Patent Agency Ranking
公开(公告)号：JPH0228173A
公开(公告)日：1990-01-30
申请号：JP8396889
申请日：1989-04-04
Applicant: MITSUI TOATSU CHEMICALS
Inventor： ONO HIROSHI , HEN PARAA
IPC: C07D319/12
Abstract: PURPOSE:To obtain a high-purity lactide useful as a raw material for polylactic acid readily and in high yield without using high purity lactic acid by reacting an alkaline (earth) metallic salt of 2-halopropionic acid as a raw material in a nonaqueous solvent under heating. CONSTITUTION:An alkali metallic salt of 2-halopropionic acid shown by formula I (A is alkali metal such as Na or K; X is Cl, Br or I) or an alkaline earth metallic salt of 2-halopropionic acid shown by formula II (B is alkaline earth metal such as Ca or Ba) is reacted in a nonaqueous solvent such as ketone, e.g. acetone, ethyl methyl ketone or methyl isobutyl ketone or ether, e.g., dioxane preferably at 100-250 deg.C under pressure approximately self generating pressure by the solvent preferably at the operation temperature for 0.1-6 hours and a prepared crude lactide is recrystallized from ethyl acetate to recover high-purity lactide shown by formula III.
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公开(公告)号：JPS63290840A
公开(公告)日：1988-11-28
申请号：JP12570987
申请日：1987-05-25
Applicant: MITSUI TOATSU CHEMICALS
Inventor： HEN PARAA , KASUGA TAKAHARU , ONO HIROSHI , IWAMOTO EIJU
IPC: C07C59/08 , C07C51/00 , C07C51/367 , C07C67/00
Abstract: PURPOSE:To economically and efficiently reduce corrosion of an apparatus and obtain lactic acid with a low content of impurities, such as metallic components, normally in high yield, by hydrolyzing 2-chloropropionic acid in the presence of an alkali under specific reaction condition. CONSTITUTION:2-Chloropropionic acid is reacted and hydrolyzed in the presence of an alkali at 100-130 deg.C for 0.5-4hr and then at 130-180 deg.C for 0.5-3hr under autogenous pressure in a hermetically sealed vessel to afford the aimed lactic acid useful as an industrial chemical, food additive, etc. Hydroxides, oxides or salts of alkali (earth) metals with weak acids, such as NaOH, KOH, Ca(OH)2, CaO or Na2CO3, are preferred as the alkali. The amount thereof used is about an equivalent amount based on the 2-chloropropionic acid, i.e. preferably 0.8-1.2mol. in the case of the NaOH or KOH and preferably 0.4-0.6mol. in the case of the Ca(OH)2, CaO or Na2CO3 based on 1mol. 2-chloropropionic acid.
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公开(公告)号：JPS63264548A
公开(公告)日：1988-11-01
申请号：JP9741887
申请日：1987-04-22
Applicant: MITSUI TOATSU CHEMICALS
Inventor： HEN PARAA , KASUGA TAKAHARU , ONO HIROSHI
Abstract: PURPOSE:To obtain purified lactic acid useful as an industrial chemical and food additive, in high efficiency, by decoloring and purifying a colored crude lactic acid with activated carbon subjected to a specific treatment, thereby highly decoloring the lactic acid in one step. CONSTITUTION:Activated carbon to be cleaned is immersed in an aqueous solution of a carboxylic acid, preferably lactic acid, etc., stirred for several min-several hr, separated from the carboxylic acid solution and washed with a solvent or water preferably at normal temperature or under slight heating. The treated activated carbon is added to a colored crude lactic acid in an amount of 0.1-5wt.% (in the case of powdery activated carbon) based on the lactic acid on dry basis, stirred for about several min-3hr at normal temperature or under slight heating and separated from the mixture by filtration to obtain decolored and purified lactic acid. The insufficient decoloring of lactic acid caused by the difference of the kind and lot of the activated carbon can be prevented and a decolored lactic acid free from contamination with metallic component and chloride can be produced.
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公开(公告)号：JPH03190836A
公开(公告)日：1991-08-20
申请号：JP32974589
申请日：1989-12-21
Applicant: MITSUI TOATSU CHEMICALS
Inventor： HEN PARAA , KIYONO SHINJI , ARASHIBA NOBUMASA
Abstract: PURPOSE:To obtain the subject compounded at a low temperature under a low pressure in high selectivity by reacting vinyl chloride with CO and H2 in the presence of the solution of a catalyst which is prepared by reacting a Rh compound and a trivalent organic phosphorus compound or an oxide thereof with CO or a mixture of CO and H2 in an organic solvent. CONSTITUTION:When vinyl chloride, carbon monoxide and hydrogen gas as raw materials are subjected to two reaction steps to obtain 2-chloro propionaldehyde, a rhodium compound, a trivalent organic phosphorus compound or an oxide thereof and carbon monoxide or a mixture of the carbon monoxide with hydrogen gas are reacted with each other in a water-insoluble or slightly soluble organic solvent to prepare a catalyst solution (the first reaction step). Vinyl chloride, carbon monoxide and hydrogen gas are reacted with each other in the presence of the prepared catalyst solution to obtain 2- chloropropionaldehyde (the second reaction step). The second step reaction is preferably performed in the presence of an organic acid and/or a base, water or a mixture of the organic acid, the base and the water.
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公开(公告)号：JPH01160939A
公开(公告)日：1989-06-23
申请号：JP31871187
申请日：1987-12-18
Applicant: MITSUI TOATSU CHEMICALS
Inventor： ONO HIROSHI , HEN PARAA , FUJITA YOSHIHIRO
IPC: C07C51/367 , B01J27/10 , C07B61/00 , C07C51/00 , C07C51/373 , C07C59/08 , C07C59/19 , C07C67/00
Abstract: PURPOSE:To obtain the title compound in high purity and yield, by hydrolyzing high-purity 2-chloropropionic acid in the presence of a specific amount of a strong alkali and a large excess of water and oxidizing the resultant aqueous solution of a high-purity alkali lactate with an O2-containing gas in the presence of an oxidation catalyst in the liquid phase. CONSTITUTION:High-purity 2-chloropropionic acid is hydrolyzed in the presence of water in an amount of >=0.5kg based on 1mol 2-chloropropionic acid and a strong alkali in an amount of 2 mol based on 1 mol 2-chloropropionic acid at 90-200 deg.C to provide an aqueous solution containing a high-purity alkali lactate. The resultant aqueous solution is then oxidized with an O2-containing gas in the presence of an oxidation catalyst (especially preferably platinum and/or palladium and an element selected from lead, tin, tellurium, indium and bismuth or a compound thereof) at 40-100 deg.C in the liquid phase to afford the aimed alkali pyruvate. Pyruvic acids are useful as a raw material for amino acids and medicines.
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