公开(公告)号：KR860001885B1

公开(公告)日：1986-10-24

申请号：KR820002182

申请日：1982-05-19

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  HIKUCHI CHOJIRO ,  GAWASHIMA NOBUYUKI ,  KAWASHIMA NOBUHIRO

IPC: C07C227/14 ,  C07C101/30

Abstract: Compds. of the formula (I) [R1,R2=H, CH3, (un)substd. Ph. or pyridyl! were prepd. Thus, 160 ml of aq. soln. of 12.9 g 3-methylaziridine-2- carbonylethylester were subjected over cationexchange resin, Lewatit S-100(H-type) (Bayer Co.), washed with 60 ml distd. H2O and absorbed on the resin. The resin was heated 7 h at 80-85 ≦̸C in 100 ml of flask, packed on column, and eluted was concd. and dried to yield 11.4 g threonine(Yield 88.6%, Purity 92.5%).

公开(公告)号：KR870001146B1

公开(公告)日：1987-06-11

申请号：KR840000031

申请日：1984-01-06

Applicant: MITSUI TOATSU CHEMICALS

Inventor： KAWASHIMA NOBUYUKI ,  YOSHIKAWA YUKIHIRO ,  OOOKA MASAHARU ,  KAWASHIMA NOBUHIRO ,  NAGAI SHOUSUKE ,  DAKANO DAKAO

IPC: C12N1/20

公开(公告)号：CA2025315C

公开(公告)日：1997-01-07

申请号：CA2025315

申请日：1990-09-13

Applicant: MITSUI TOATSU CHEMICALS ,  MOCHIDA PHARM CO LTD

Inventor： SHIMAZAKI YUKIO ,  KAWASHIMA NOBUHIRO ,  YOSHIOKA MIKI ,  TANAKA YASUHITO ,  TANAKA RYO ,  SAKAI KIYOSHI ,  ISHIWARI HISAHIRO

IPC: A61K9/08 ,  A61K38/00 ,  A61K38/49 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  A61K47/30

Abstract: Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

公开(公告)号：DK169680B1

公开(公告)日：1995-01-09

申请号：DK418487

申请日：1987-08-11

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MORII MITSUYOSHI ,  OHOKA MASAHARU ,  SUZUKI TOSHIHIKO ,  SUZUKI KATSUYUKI ,  KAWASHIMA NOBUHIRO ,  MORII NORIKO ,  MORI KUNIZOU

IPC: C12N9/64 ,  A61K38/00 ,  C12N9/72 ,  C07K1/22

Abstract: Tissue plasminogen activator (tPA) species having a specific molecular weight can be isolated in a purified form from a crude tPA preparation containing various tPA species having different molecular weights by bringing the crude tPA preparation into contact with hydroxyapatite and then separately eluting the adsorbed tPA species with eluents having different pHs and/or salt concentrations.

公开(公告)号：DE3780883D1

公开(公告)日：1992-09-10

申请号：DE3780883

申请日：1987-08-11

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MORII MITSUYOSHI MITSUI TOATSU ,  OHOKA MASAHARU MITSUI TOATSU I ,  SUZUKI TOSHIHIKO ,  SUZUKI KATSUYUKI ,  KAWASHIMA NOBUHIRO ,  MORII NORIKO MITSUI TOATSU APA ,  MORI KUNIZOU MITSUI TOATSU IIJ

IPC: C12N9/64 ,  A61K38/00 ,  C12N9/72 ,  A61K37/54

Abstract: Tissue plasminogen activator (tPA) species having a specific molecular weight can be isolated in a purified form from a crude tPA preparation containing various tPA species having different molecular weights by bringing the crude tPA preparation into contact with hydroxyapatite and then separately eluting the adsorbed tPA species with eluents having different pHs and/or salt concentrations.

公开(公告)号：AU627621B2

公开(公告)日：1992-08-27

申请号：AU6246690

申请日：1990-09-13

Applicant: MITSUI TOATSU CHEMICALS

Inventor： SHIMAZAKI YUKIO ,  KAWASHIMA NOBUHIRO ,  YOSHIOKA MIKI ,  TANAKA YASUHITO ,  TANAKA RYO ,  SAKAI KIYOSHI ,  ISHIWARI HISAHIRO

IPC: A61K9/08 ,  A61K38/00 ,  A61K38/49 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  A61K37/47

Abstract: Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

公开(公告)号：NO904120L

公开(公告)日：1991-03-22

申请号：NO904120

申请日：1990-09-20

Applicant: MITSUI TOATSU CHEMICALS ,  MOCHIDA PHARM CO LTD

Inventor： SHIMAZAKI YUKIO ,  KAWASHIMA NOBUHIRO ,  YOSHIOKA MIKI ,  TANAKA YASUHITO ,  TANAKA RYO ,  SAKAI KIYOSHI ,  ISHIWARI HISAHIRO

IPC: A61K9/08 ,  A61K38/00 ,  A61K38/49 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  A61K37/02

Abstract: Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

公开(公告)号：FI904618A0

公开(公告)日：1990-09-19

申请号：FI904618

申请日：1990-09-19

Applicant: MITSUI TOATSU CHEMICALS ,  MOCHIDA PHARM CO LTD

Inventor： SHIMAZAKI YUKIO ,  KAWASHIMA NOBUHIRO ,  YOSHIOKA MIKI ,  TANAKA YASUHITO ,  TANAKA RYO ,  SAKAI KIYOSHI ,  ISHIWARI HISAHIRO

IPC: A61K9/08 ,  A61K38/00 ,  A61K38/49 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  A61K

Abstract: Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

公开(公告)号：AU594186B2

公开(公告)日：1990-03-01

申请号：AU7756587

申请日：1987-08-10

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MORII MITSUYOSHI ,  MORII NORIKO ,  OHOKA MASAHARU ,  SUZUKI TOSHIHIKO ,  SUZUKI KATSUYUKI ,  KAWASHIMA NOBUHIRO ,  MORI KUNIZO

IPC: C12N9/64 ,  A61K38/00 ,  C12N9/72 ,  A61K37/54 ,  C07K3/20 ,  C12N9/76

公开(公告)号：AU590840B2

公开(公告)日：1989-11-16

申请号：AU7241887

申请日：1987-05-01

Applicant: MITSUI TOATSU CHEMICALS

Inventor： OHOKA MASAHARU ,  MORII MITSUYOSHI ,  SUZUKI TOSHIHIKO ,  SUZUKI KATSUYUKI ,  KAWASHIMA NOBUHIRO ,  MORII NORIKO ,  MORI KUNIZO

IPC: A61K38/00 ,  C12N9/72 ,  C07K3/20