公开(公告)号：US20220380484A1

公开(公告)日：2022-12-01

申请号：US17771982

申请日：2020-10-28

Applicant: Monash University

Inventor： James Whisstock ,  Ruby Law ,  Adam Quek ,  Paul Conroy ,  Dena Lyras ,  Guojie Wu

IPC: C07K16/40 ,  A61P7/04

Abstract: The present invention relates to antigen binding proteins comprising an antigen binding domain that binds to plasminogen, wherein the antigen binding protein reduces the activation of plasminogen to plasmin, pharmaceutical compositions comprising the same, and methods and uses thereof.

公开(公告)号：US20230220112A1

公开(公告)日：2023-07-13

申请号：US17772090

申请日：2020-10-28

Applicant: MONASH UNIVERSITY

Inventor： James Whisstock ,  Ruby Law ,  Adam Quek ,  Paul Conroy ,  Guojie Wu

IPC: C07K16/40 ,  A61P7/00

CPC classification number: C07K16/40 ,  A61P7/00 ,  C07K2317/92 ,  C07K2317/567 ,  C07K2317/565

Abstract: The present invention provides an antigen binding protein comprising an antigen binding domain that binds to plasmin, wherein the antigen binding protein reduces the activity of plasmin. The invention also provides compositions comprising the antigen binding protein, and uses and method of treatment comprising the same.

公开(公告)号：US20220267751A1

公开(公告)日：2022-08-25

申请号：US17626168

申请日：2020-07-10

Applicant: Monash University

Inventor： James Whisstock ,  Ruby Law ,  Adam Quek ,  Paul Conroy

IPC: C12N9/68 ,  C07K14/81

Abstract: The present invention relates to methods of producing recombinant plasminogen in a mammalian expression system. A method for producing plasminogen, the method comprising (i) providing a host cell comprising a first recombinant polynucleotide encoding plasminogen and a second recombinant polynucleotide encoding a plasminogen activation inhibitor; (ii) culturing said host cell in a suitable culture medium under conditions to effect expression of plasminogen from the first polynucleotide and plasminogen activation inhibitor from the second polynucleotide.