公开(公告)号：US20230220112A1

公开(公告)日：2023-07-13

申请号：US17772090

申请日：2020-10-28

Applicant: MONASH UNIVERSITY

Inventor： James Whisstock ,  Ruby Law ,  Adam Quek ,  Paul Conroy ,  Guojie Wu

IPC: C07K16/40 ,  A61P7/00

CPC classification number: C07K16/40 ,  A61P7/00 ,  C07K2317/92 ,  C07K2317/567 ,  C07K2317/565

Abstract: The present invention provides an antigen binding protein comprising an antigen binding domain that binds to plasmin, wherein the antigen binding protein reduces the activity of plasmin. The invention also provides compositions comprising the antigen binding protein, and uses and method of treatment comprising the same.

公开(公告)号：US20240100134A1

公开(公告)日：2024-03-28

申请号：US18273156

申请日：2022-01-20

Applicant: Monash University

Inventor： James C. Whisstock ,  Ruby HP Law ,  Adam J. Quek ,  Christoph Hagemeyer ,  Mikael Martino ,  Guojie Wu ,  Yen-Zhen Lu

IPC: A61K38/48 ,  A61P7/02 ,  C12N9/68 ,  C12N15/62

CPC classification number: A61K38/484 ,  A61P7/02 ,  C12N9/6435 ,  C12N15/62 ,  C12Y304/21007 ,  C07K2319/30

Abstract: The present invention relates to chimeric and fusion proteins and their compositions, and the use of such proteins and compositions in the prevention and/or treatment diseases or conditions requiring plasminogen supplementation. In one aspect, the invention provides a chimeric or fusion protein comprising plasminogen and an Fc region of an antibody.

公开(公告)号：US20220380484A1

公开(公告)日：2022-12-01

申请号：US17771982

申请日：2020-10-28

Applicant: Monash University

Inventor： James Whisstock ,  Ruby Law ,  Adam Quek ,  Paul Conroy ,  Dena Lyras ,  Guojie Wu

IPC: C07K16/40 ,  A61P7/04

Abstract: The present invention relates to antigen binding proteins comprising an antigen binding domain that binds to plasminogen, wherein the antigen binding protein reduces the activation of plasminogen to plasmin, pharmaceutical compositions comprising the same, and methods and uses thereof.