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1.发明授权Microfluidic apparatus and methods for performing blood typing and crossmatching 有权用于进行血液分型和交配的微流体装置和方法公开(公告)号：US09146246B2
公开(公告)日：2015-09-29
申请号：US13660834
申请日：2012-10-25
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Diane Wierzbicki , John Clemmens , Jason Capodanno , John R. Williford , Carolina Elmufdi , Isaac Sprague
CPC classification number: G01N33/53 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/161 , G01N33/5304 , G01N33/80
Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.
Abstract translation: 提供用于凝集反应的微流控盒。 药筒包括具有至少两个进气通道的微流体反应通道，一个用于含抗原的流体，另一个用于含抗体流体，结合到通过并入下游流动控制通道而修改的反应通道。 在低雷诺数下，两个输入流在反应通道中层叠在另一个之上，并形成流动的，未混合的水平分层的层状流体扩散（HLFD）界面，持续延长的反应时间。 令人惊奇的是，本发明的微流体回路的设计，表面性质和流动状态增强了在分层界面处的抗体介导的凝集的检测。 抗原：涉及通过这些装置增强的凝集的抗体反应可用于血型，输血交配和免疫诊断凝集试验。
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公开(公告)号：US10107797B2
公开(公告)日：2018-10-23
申请号：US14830539
申请日：2015-08-19
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Diane Wierzbicki , John Clemmens , Jason Capodanno , John R. Williford , Carolina Elmufdi , Isaac Sprague
Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.
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Patent Agency Ranking
公开(公告)号：US20150158026A1
公开(公告)日：2015-06-11
申请号：US14610493
申请日：2015-01-30
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
IPC: B01L3/00 , G01N33/543
CPC classification number: B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
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公开(公告)号：US20160193603A1
公开(公告)日：2016-07-07
申请号：US14819182
申请日：2015-08-05
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Isaac Sprague , Matthew Scott Bragd , Jason Capodanno
CPC classification number: B01L3/50273 , B01L3/52 , B01L7/52 , B01L7/525 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/03 , G01N21/0332 , G01N21/17 , G01N21/64 , G01N21/6428 , Y10T137/0318
Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.
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5.发明申请MICROFLUIDIC APPARATUS AND METHODS FOR PERFORMING BLOOD TYPING AND CROSSMATCHING 有权微血管装置及其方法，用于进行血液分型和交叉测量公开(公告)号：US20130142708A1
公开(公告)日：2013-06-06
申请号：US13660834
申请日：2012-10-25
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Diane Wierzbicki , John Clemmens , Jason Capodanno , John R. Williford , Carolina Elmufdi , Isaac Sprague
IPC: G01N33/80
CPC classification number: G01N33/53 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/161 , G01N33/5304 , G01N33/80
Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.
Abstract translation: 提供用于凝集反应的微流控盒。 药筒包括具有至少两个进气通道的微流体反应通道，一个用于含抗原的流体，另一个用于含抗体流体，结合到通过并入下游流动控制通道而修改的反应通道。 在低雷诺数下，两个输入流在反应通道中层叠在另一个之上，并形成流动的，未混合的水平分层的层状流体扩散（HLFD）界面，持续延长的反应时间。 令人惊奇的是，本发明的微流体回路的设计，表面性质和流动状态增强了在分层界面处的抗体介导的凝集的检测。 抗原：涉及通过这些装置增强的凝集的抗体反应可用于血型，输血交配和免疫诊断凝集试验。
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公开(公告)号：US09895692B2
公开(公告)日：2018-02-20
申请号：US14819182
申请日：2015-08-05
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Isaac Sprague , Matthew Scott Bragd , Jason Capodanno
CPC classification number: B01L3/50273 , B01L3/52 , B01L7/52 , B01L7/525 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/03 , G01N21/0332 , G01N21/17 , G01N21/64 , G01N21/6428 , Y10T137/0318
Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.
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公开(公告)号：US20160209431A1
公开(公告)日：2016-07-21
申请号：US14830539
申请日：2015-08-19
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Diane Wierzbicki , John Clemmens , Jason Capodanno , John R. Williford , Carolina Elmufdi , Isaac Sprague
CPC classification number: G01N33/53 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/161 , G01N33/5304 , G01N33/80
Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.
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