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公开(公告)号：US10065186B2
公开(公告)日：2018-09-04
申请号：US14653731
申请日：2013-12-20
Applicant: Micronics, Inc.
Inventor： Andrew Kolb , Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , Martha Stone
IPC: B01L3/00 , F16K99/00 , B81B3/00 , B81C1/00 , B29C43/02 , B29C65/16 , F04B43/04 , B29K101/00 , B29L9/00 , B29L31/00
Abstract: Fluidic cartridges, and manufacture thereof, having a plurality of circuit element subtypes containing pneumatically operated diaphragm members, where the diaphragm materials are selected for yield point, chemical resistance, breathability and other properties individually according to the fluidic element subtype are provided. A process of in-situ edge-bonded decoupage for forming diaphragm members inside a cartridge, and fluidic circuits having diaphragm members as active and passive circuit elements, including pumps, valves, vents, waste receptacles, reagent reservoirs, and cuvettes with optical windows, where the material composition of each individual diaphragm member may be selected from an assortment of materials during manufacture are also provided.
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Patent Agency Ranking
公开(公告)号：US09895692B2
公开(公告)日：2018-02-20
申请号：US14819182
申请日：2015-08-05
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Isaac Sprague , Matthew Scott Bragd , Jason Capodanno
CPC classification number: B01L3/50273 , B01L3/52 , B01L7/52 , B01L7/525 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/03 , G01N21/0332 , G01N21/17 , G01N21/64 , G01N21/6428 , Y10T137/0318
Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.
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公开(公告)号：US20160193603A1
公开(公告)日：2016-07-07
申请号：US14819182
申请日：2015-08-05
Applicant: Micronics, Inc.
Inventor： C. Frederick Battrell , Isaac Sprague , Matthew Scott Bragd , Jason Capodanno
CPC classification number: B01L3/50273 , B01L3/52 , B01L7/52 , B01L7/525 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/03 , G01N21/0332 , G01N21/17 , G01N21/64 , G01N21/6428 , Y10T137/0318
Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.
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公开(公告)号：US20150352549A1
公开(公告)日：2015-12-10
申请号：US14653731
申请日：2013-12-20
Applicant: MICRONICS, INC.
Inventor： Andrew Kolb , Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , Martha Stone
CPC classification number: B01L3/50273 , B01L3/502707 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B29C43/021 , B29C65/16 , B29K2101/00 , B29L2009/00 , B29L2031/7496 , B81B2201/052 , B81C1/00119 , F04B43/043 , F16K99/0015 , F16K99/0059 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T156/1026
Abstract: Fluidic cartridges, and manufacture thereof, having a plurality of circuit element subtypes containing pneumatically operated diaphragm members, where the diaphragm materials are selected for yield point, chemical resistance, breathability and other properties individually according to the fluidic element subtype are provided. A process of in-situ edge-bonded decoupage for forming diaphragm members inside a cartridge, and fluidic circuits having diaphragm members as active and passive circuit elements, including pumps, valves, vents, waste receptacles, reagent reservoirs, and cuvettes with optical windows, where the material composition of each individual diaphragm member may be selected from an assortment of materials during manufacture are also provided.
Abstract translation: 提供具有包含气动操作的隔膜部件的多个电路元件亚型的流体盒及其制造，其中根据流体元件亚型分别选择隔膜材料用于屈服点，耐化学性，透气性和其它性质。 一种用于在筒内形成膜片构件的原位边缘粘合去耦的过程，以及具有作为主动和被动电路元件的隔膜构件的流体回路，包括泵，阀，通风口，废物容器，试剂储存器和具有光学窗口的比色杯， 其中还提供了每个单独隔膜构件的材料组成可以在制造期间从各种材料中选择。
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公开(公告)号：US20150321193A1
公开(公告)日：2015-11-12
申请号：US14653737
申请日：2013-12-20
Applicant: MICRONICS, INC.
Inventor： Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , C. Frederick Battrell
Abstract: Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.
Abstract translation: 微流体电路元件，例如微型阀，微泵或微量元件，由微腔分隔成由第一内壁限定的第一子空腔和由第二内壁界定的第二子腔，微腔由隔膜腹板分隔，其中隔膜腹板的特征在于 具有接触第一内壁的第一状态的薄膜和接触第二内壁的第二状态，并且在第一状态和第二状态之间基本上没有弹性运动，薄膜纤维网已被拉伸超过其屈服点之前或 在使用期间提供。 所公开的元件使得隔膜在微腔中更快且更有效地循环并增加隔膜表面积。 在优选实施例中，微流体电路元件被气动驱动并且控制微量测量装置中的流体的运动。
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6.发明申请公开(公告)号：US20170113221A1
公开(公告)日：2017-04-27
申请号：US15317365
申请日：2015-06-11
Applicant: Micronics, Inc.
Inventor： Danny Hoffman , Asa Bergdahl , Megan Couch , Raf Rivera , Matthew Scott Bragd , Alan K. Lofquist , Andrew Kolb , Justin L. Kay
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/52 , B01L3/527 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N2035/00158
Abstract: Disclosed is a microassay testing system, including a microfluidic cartridge and a compact microprocessor-controlled instrument for fluorometric assays in liquid samples, the cartridge having integrated process controls and positive and negative assay controls. The instrument has a scanning detector head incorporating multiple optical channels. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a process control. Integrated positive and negative assay controls provide enhanced assay validation capabilities and facilitate analysis of test results. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.
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