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    Microfluidic apparatus and methods for performing blood typing and crossmatching
    1.
    发明授权
    Microfluidic apparatus and methods for performing blood typing and crossmatching 有权

    公开(公告)号：US10107797B2

    公开(公告)日：2018-10-23

    申请号：US14830539

    申请日：2015-08-19

    Applicant: Micronics, Inc.

    Inventor： C. Frederick Battrell ,  Diane Wierzbicki ,  John Clemmens ,  Jason Capodanno ,  John R. Williford ,  Carolina Elmufdi ,  Isaac Sprague

    IPC: B01L3/00 ,  G01N33/53 ,  G01N33/80

    Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.

    LOW ELASTICITY FILMS FOR MICROFLUIDIC USE
    5.
    发明申请
    LOW ELASTICITY FILMS FOR MICROFLUIDIC USE 审中-公开
    用于微流感使用的低弹性膜

    公开(公告)号：US20150321193A1

    公开(公告)日：2015-11-12

    申请号：US14653737

    申请日：2013-12-20

    Applicant: MICRONICS, INC.

    Inventor： Isaac Sprague ,  Justin L. Kay ,  Matthew Scott Bragd ,  C. Frederick Battrell

    IPC: B01L3/00 ,  F16K99/00

    Abstract: Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.

    Abstract translation: 微流体电路元件，例如微型阀，微泵或微量元件，由微腔分隔成由第一内壁限定的第一子空腔和由第二内壁界定的第二子腔，微腔由隔膜腹板分隔，其中隔膜腹板的特征在于 具有接触第一内壁的第一状态的薄膜和接触第二内壁的第二状态，并且在第一状态和第二状态之间基本上没有弹性运动，薄膜纤维网已被拉伸超过其屈服点之前或 在使用期间提供。 所公开的元件使得隔膜在微腔中更快且更有效地循环并增加隔膜表面积。 在优选实施例中，微流体电路元件被气动驱动并且控制微量测量装置中的流体的运动。

    COMPOSITIONS AND METHODS FOR DEHYDRATED STORAGE OF ON-BOARD REAGENTS IN MICROFLUIDIC DEVICES
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR DEHYDRATED STORAGE OF ON-BOARD REAGENTS IN MICROFLUIDIC DEVICES 审中-公开
    微流感器件中板载试剂的脱水储存组合物和方法

    公开(公告)号：US20150152481A1

    公开(公告)日：2015-06-04

    申请号：US14554720

    申请日：2014-11-26

    Applicant: Micronics, Inc.

    Inventor： C. Frederick Battrell ,  Denise Maxine Hoekstra ,  Joan Haab ,  John R. Williford ,  Sabrina N. Gates ,  Elizabeth R. Leber ,  Isaac Sprague

    IPC: C12Q1/68

    CPC classification number: C12Q1/686 ,  C12Q1/6806 ,  C12Q2527/125

    Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.

    Abstract translation: 描述制造方法和组合物用于生产具有用于分子生物学测试的载体试剂的自含微流控盒装置。 敏感试剂以干燥形式储存而不进行冻干或冷冻，并在使用时与生物样品或样品洗脱液在使用时重构。 制造方法包括片和卷制造方法，其中将试剂印刷在适当位置并在凝胶玻璃化之前在单个微流体盒内密封。

    MICROFLUIDIC APPARATUS AND METHODS FOR PERFORMING BLOOD TYPING AND CROSSMATCHING
    7.
    发明申请
    MICROFLUIDIC APPARATUS AND METHODS FOR PERFORMING BLOOD TYPING AND CROSSMATCHING 有权
    微血管装置及其方法，用于进行血液分型和交叉测量

    公开(公告)号：US20130142708A1

    公开(公告)日：2013-06-06

    申请号：US13660834

    申请日：2012-10-25

    Applicant: Micronics, Inc.

    Inventor： C. Frederick Battrell ,  Diane Wierzbicki ,  John Clemmens ,  Jason Capodanno ,  John R. Williford ,  Carolina Elmufdi ,  Isaac Sprague

    IPC: G01N33/80

    CPC classification number: G01N33/53 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/161 ,  G01N33/5304 ,  G01N33/80

    Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.

    Abstract translation: 提供用于凝集反应的微流控盒。 药筒包括具有至少两个进气通道的微流体反应通道，一个用于含抗原的流体，另一个用于含抗体流体，结合到通过并入下游流动控制通道而修改的反应通道。 在低雷诺数下，两个输入流在反应通道中层叠在另一个之上，并形成流动的，未混合的水平分层的层状流体扩散（HLFD）界面，持续延长的反应时间。 令人惊奇的是，本发明的微流体回路的设计，表面性质和流动状态增强了在分层界面处的抗体介导的凝集的检测。 抗原：涉及通过这些装置增强的凝集的抗体反应可用于血型，输血交配和免疫诊断凝集试验。

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