公开(公告)号：JP2004008634A

公开(公告)日：2004-01-15

申请号：JP2002168588

申请日：2002-06-10

Applicant: JAPAN SCIENCE & TECH CORP ,  NAT INST FOR MATERIALS SCIENCE

Inventor： TANAKA JUNZO ,  TAGUCHI TETSUSHI

IPC: A61L27/00 ,  A61L27/12 ,  A61L27/24 ,  A61L27/38 ,  A61L27/46 ,  A61L27/58

Abstract: PROBLEM TO BE SOLVED: To provide a scaffolding material for effectively regenerating the interface of a hard tissue and a soft tissue and to provide an implant capable of sufficiently filling a hard tissue-soft tissue defficient part by utilizing the scaffolding material. SOLUTION: A biodegradable polymeric material is dipped in a calcium ion-containing solution and a phosphate ion-containing solution to add calcium phosphate to the interior of the biodegradable polymeric material in a gradient state. The biodegradable polymeric material is utilized as a scaffold to regenerate the hard tissue-soft tissue interface. COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2002080501A

公开(公告)日：2002-03-19

申请号：JP2000273187

申请日：2000-09-08

Applicant: JAPAN SCIENCE & TECH CORP ,  NAT INST FOR MATERIALS SCIENCE ,  SEIKAGAKU KOGYO CO LTD ,  NITTA GELATIN KK ,  TANAKA JUNZO

Inventor： TANAKA JUNZO ,  TAGUCHI TETSUSHI ,  MIYAZAKI KIYOUSUKE ,  SAKURA YOSHIYUKI ,  OTSUKA TATSURO ,  BANDAI YOSHINOBU

IPC: A61L27/00 ,  C08B37/08

Abstract: PROBLEM TO BE SOLVED: To develop a material for anagenesis which is useful as a matrix of various anageneses of cartilage, liver, blood vessel, nerve, or the like, and which exhibits physical properties extremely similar to each tissue and has an excellent biological function in a system capable of putting the material in a mold and molding the material. SOLUTION: This glycosaminoglycan-polycation complex for a matrix of anagenesis is crosslinked by a condensation reaction between glycosaminoglycan and a polycation. The glycosaminoglycan-polycation complex is produced by crosslinking the glycosaminoglycan and the polycation in a salt concentration not to form a polyion complex by a condensation reaction using water-soluble carbodiimide as a condensation agent.

公开(公告)号：JP2006346049A

公开(公告)日：2006-12-28

申请号：JP2005174414

申请日：2005-06-14

Applicant: NAT INST FOR MATERIALS SCIENCE ,  FURUUCHI KAGAKU KK

Inventor： TAGUCHI TETSUSHI ,  KAKINOKI SACHIRO ,  TANAKA JUNZO ,  SAITO HIROSHI

IPC: A61L24/00

Abstract: PROBLEM TO BE SOLVED: To provide an in vivo decomposing and absorbing adhesive medical material to be strongly adhered in a short time without using dimethylsulfoxide which is an organic solvent as a solvent. SOLUTION: In the solid-liquid mixed type two-component system in vivo decomposing and absorbing adhesive medical material, biodegradable polymer dissolved in the solvent composed of distilled water, an aqueous solution containing metal ions to electrostatically interact with the biodegradable polymer and interact by a chelate effect or a buffer solution is used as an adhesive component, and an organic acid derivative in a powder shape obtained by modifying two carboxyl groups of dicarboxylic acid or two or three carboxyl groups of tricarboxylic acid by an electron withdrawing group is used as a hardening component. COPYRIGHT: (C)2007,JPO&INPIT

公开(公告)号：EP1419792A4

公开(公告)日：2005-01-12

申请号：EP02755730

申请日：2002-07-31

Applicant: JAPAN SCIENCE & TECH AGENCY ,  NAT INST FOR MATERIALS SCIENCE ,  NITTA GELATIN KK

Inventor： TANAKA JUNZO ,  TAGUCHI TETSUSHI ,  MIYAZAKI TADASUKE ,  SAKURA YOSHIYUKI ,  OHTSUKA TATSURO ,  MANDAI YOSHINOBU

IPC: A61L27/00 ,  A61K31/785 ,  A61L27/20 ,  A61L27/26 ,  A61L27/38 ,  A61L27/44 ,  A61L27/48 ,  A61L27/50 ,  A61P19/02 ,  C08B37/00 ,  C08B37/08 ,  C08G63/91 ,  C08G65/322 ,  C08G65/329 ,  C08G65/333 ,  C08H1/06 ,  A61L27/24 ,  C12M3/00

CPC classification number: A61L27/3852 ,  A61L27/20 ,  A61L27/26 ,  A61L27/44 ,  A61L27/48 ,  A61L27/50 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08G65/322 ,  C08G65/329 ,  C08G65/33337 ,  C08H1/06 ,  C08L2203/02 ,  C08L5/00

Abstract: In a conventional process for producing a glycosaminoglycan-polycation complex to be used in producing tissue regeneration matrixes for cartilage, etc., a crosslinking reaction is carried out in an alcohol or water. Therefore, it is feared that an injectable crosslinked biological substance might exert an undesirable effect (cell death) on cells and tissues. Moreover, a polyion complex (a non-homogeneous precipitate) is formed in this case. A glycosaminoglycan-polycation complex is formed by crosslinking glycosaminoglycan and polycation under physiological conditions with the use of 0.3 to 3 mM of a crosslinking agent which has two or more electrophilic leaving groups (for example, succinimidyl group or its derivative) at the carboxyl end of polyethylene glycol. Since the synthesis can be carried out under physiological conditions, the crosslinking can be achieved by preliminarily mixing the cells.

公开(公告)号：EP2974752A4

公开(公告)日：2016-10-19

申请号：EP14764880

申请日：2014-03-11

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： TAGUCHI TETSUSHI

IPC: A61L27/00 ,  A61L24/00 ,  A61L24/10 ,  A61L27/12 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54

CPC classification number: A61L27/12 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/104 ,  A61L24/108 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L2400/12 ,  A61L2430/02 ,  C08L89/06

公开(公告)号：EP2626087A4

公开(公告)日：2014-09-17

申请号：EP11830691

申请日：2011-10-05

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： TAGUCHI TETSUSHI

IPC: A61L24/10

CPC classification number: A61L24/104

公开(公告)号：EP2626086A4

公开(公告)日：2014-09-17

申请号：EP11830649

申请日：2011-10-04

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： TAGUCHI TETSUSHI ,  MATSUDA MIYUKI

IPC: A61L24/10 ,  C09J189/06

CPC classification number: C09J189/00 ,  A61L24/104

公开(公告)号：CA2499606A1

公开(公告)日：2004-03-25

申请号：CA2499606

申请日：2003-09-11

Applicant: NAT INST FOR MATERIALS SCIENCE ,  FURUUCHI CHEMICAL CORP

Inventor： TANAKA JUNZO ,  TAGUCHI TETSUSHI ,  KOBAYASHI NAOTOSHI ,  SAITO HIROSHI

IPC: C07D285/00 ,  A61L24/00 ,  A61L27/00 ,  C07C233/03 ,  C07C235/06 ,  C07C235/80 ,  C07D207/02 ,  C07D207/408 ,  C07D207/46 ,  C08H1/00 ,  A61L24/10 ,  A61L24/08

Abstract: It is pointed out that the existing crosslinking agents and condensing agent s having been employed in biological adhesives and in treating medical devices such as cardiac valves, which are non-natural products synthesized artificially, are not metabolized in vivo and exhibit toxicity to living bodies. Therefore, these products can be used only in a restricted amount an d for limited purposes in the clinical field. It is intended to provide biological low-molecular weight derivatives obtained by modifying a carboxyl group of a biological low-molecular weight compound with N-hydroxysuccinimid e, N-hydroxysulfosuccinimide or derivatives thereof and crosslinked high- molecular weight compounds obtained by crosslinking various high-molecular weight compounds with the use of the above derivative.

公开(公告)号：EP2644734A4

公开(公告)日：2016-10-19

申请号：EP11843581

申请日：2011-11-25

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： TAGUCHI TETSUSHI ,  KATADA YASUYUKI ,  NAGAI RYOZO ,  MANABE ICHIRO ,  FUJIU KATSUHITO

IPC: C22C38/00 ,  A61L29/00 ,  A61L31/02 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/22 ,  C22C38/26 ,  C22C38/28 ,  C22C38/32 ,  C22C38/44

CPC classification number: A61F2/82 ,  A61L31/022 ,  C22C38/001 ,  C22C38/002 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/22 ,  C22C38/26 ,  C22C38/28 ,  C22C38/32 ,  C22C38/44

Abstract: A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30 % by mass of Cr, from 1 to 10 % by mass of Mo, and from 0.5 to 1 % by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.

公开(公告)号：EP1676813A4

公开(公告)日：2009-08-12

申请号：EP04723345

申请日：2004-03-25

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： TANAKA JUNZO ,  IKOMA TOSHIYUKI ,  TAGUCHI TETSUSHI

IPC: C01B25/32 ,  B01J20/04 ,  B01J20/28 ,  B01J20/282

CPC classification number: B01J20/3204 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3236 ,  B01J20/3272 ,  B01J20/3293 ,  C01B25/32 ,  Y10T428/2982 ,  Y10T428/2991

Abstract: A porous and spherical calcium phosphate particle which is substituted with a metal ion or has a metal ion carried on the surface thereof, and has a particle diameter of 0.1 to 100 µm. The calcium phosphate particle is a novel functional particle which is useful, for example, as a material for use in gas chromatography allowing the separation of a chemical substance of a trace amount with high accuracy.