公开(公告)号：JP2001231797A

公开(公告)日：2001-08-28

申请号：JP2000046450

申请日：2000-02-23

Applicant: NAT INST FOR MATERIALS SCIENCE ,  JAPAN SCIENCE & TECH CORP ,  TAMACHI KOGYO KK ,  ESUKOMU KK

Inventor： TANAKA JUNZO ,  KIKUCHI MASANORI ,  IKOMA TOSHIYUKI ,  OTA KUNIHIRO ,  YOKOYAMA YOSHICHIKA

IPC: A61L27/00 ,  A61F2/28 ,  C04B35/00

Abstract: PROBLEM TO BE SOLVED: To provide a modularized artificial bone which makes it possible to easily obtain shapes and dimensions desired to be complemented, does not exert burden to the living body and may be easily integrated with the osteostructure of the living body. SOLUTION: The artificial bone to be replaced in the defective part of the hard tissue or soft tissue of the living body is formed by bundling plural rod-like modules 3 and integrally fixing the bundles. The modules 3 are recommended to have >=1 annular grooves on the circumferences and to be formed with tubular spaces (corresponding to Haversian canals) in a direction orthogonal with an axial direction. The sectional shapes of the modules 3 are preferably polygonal shapes having rounded corners and tubular spaces (corresponding to Volkmann's vessels) are preferably formed between the modules 3 and the modules 3. The module defective part for at least one piece exists and this part is preferably the tubular space 2 (corresponding to the spinal fluid vessel) in the axial direction. The modules 3 are preferably made from metals for the living body, bioactive ceramics, bioinert ceramics, high-polymer materials or >=2 kinds of the composites selected from the groups consisting thereof.

公开(公告)号：WO2004089417A9

公开(公告)日：2005-01-06

申请号：PCT/JP2004005007

申请日：2004-04-07

Applicant: NAT INST FOR MATERIALS SCIENCE ,  LTT BIO PHARMA CO LTD ,  TANAKA JUNZO ,  IKOMA TOSHIYUKI ,  MIZUSHIMA YUTAKA

Inventor： TANAKA JUNZO ,  IKOMA TOSHIYUKI ,  MIZUSHIMA YUTAKA

IPC: A61K9/50 ,  A61K9/54 ,  A61K31/573 ,  A61K31/7088 ,  A61K31/726 ,  A61K38/00 ,  A61K38/04 ,  A61K38/21 ,  A61K38/22 ,  A61K38/28 ,  A61K38/43 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K47/04 ,  A61K47/36 ,  A61K48/00 ,  A61P5/00 ,  A61P9/00 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  A61K38/20

CPC classification number: A61K31/7088 ,  A61K9/5073 ,  A61K31/726

Abstract: A drug-enclosing multilayer structure particulate comprising a calcium carbonate compound particulate enclosing a biologically active substance wherein occasionally ions of at least one metal selected from among zinc, magnesium, iron and copper are contained and, superimposed on the surface thereof, a coating of calcium phosphate porous material and/or biopolymer.

Abstract translation: 一种药物封闭多层结构颗粒，其包含包围生物活性物质的碳酸钙化合物颗粒，其中偶尔含有选自锌，镁，铁和铜中的至少一种金属的离子，并且在其表面上叠加钙 磷酸盐多孔材料和/或生物聚合物。

公开(公告)号：JP2004256723A

公开(公告)日：2004-09-16

申请号：JP2003050589

申请日：2003-02-27

Applicant: JAPAN SCIENCE & TECH AGENCY ,  NAT INST FOR MATERIALS SCIENCE

Inventor： IKOMA TOSHIYUKI ,  TANAKA JUNZO ,  AZUMA AKIFUMI

IPC: A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  C08G63/06 ,  C08L101/16

Abstract: PROBLEM TO BE SOLVED: To provide a method of preparing a new hydrogel, which can seal physiologically active materials without denaturing or inactivating. SOLUTION: The preparation method of a hydrogel comprises a step of mixing a malic acid solution of a concentration not lower than 0.2 mol/L and zinc ions in the zinc/malic acid molar ratio of not less than 0.5 and a step of gelling the mixture containing malic acid and zinc ion by adding an alkali. The malic acid/ zinc hydrogel is prepared by the above method. COPYRIGHT: (C)2004,JPO&NCIPI

公开(公告)号：JP2002219167A

公开(公告)日：2002-08-06

申请号：JP2001017694

申请日：2001-01-25

Applicant: JAPAN SCIENCE & TECH CORP ,  NAT INST FOR MATERIALS SCIENCE ,  IBARAKI PREFECTURE ,  ESUKOMU KK ,  TAMACHI KOGYO KK ,  TAKI CHEMICAL

Inventor： SAKANE MASATAKA ,  YOKOYAMA YOSHICHIKA ,  TANAKA JUNZO ,  FUKUZAKI HIRONOBU ,  OTA KUNIHIRO ,  YAMAGUCHI ISAMU ,  KIKUCHI MASANORI ,  IKOMA TOSHIYUKI

IPC: A61L27/00

Abstract: PROBLEM TO BE SOLVED: To provide a method and a device for alternating immersion for making a combination of a ligament and a calcium phosphate-base compound put to practice at an operation site. SOLUTION: The alternating immersion device for treating the living-body tissue material comprises a plurality of chemical-solution feed containers A, B and C, a plurality of infusion tubes 4A, 4B and 4C which are connected to the respective containers A, B and C, a discharge tube 4D for discharging a chemical solution within an immersion container, and a means for controlling the opening/closing of the infusion tubes 4A, 4B and 4C and the discharge tube 4D. The alternating immersion device brings about the combination of calcium phosphate with a surface and an inside of the living-body tissue material treated with an aqueous solution containing calcium and an aqueous solution containing phosphoric acid.

公开(公告)号：EP1785186A4

公开(公告)日：2008-05-07

申请号：EP05749075

申请日：2005-06-07

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： YAMADA HIROHISA ,  TAMURA KENJI ,  TANAKA JUNZO ,  IKOMA TOSHIYUKI ,  SUETSUGU YASUSHI ,  MORIYOSHI YUSUKE ,  WATANABE YUJIRO

IPC: B01J20/06 ,  B01J20/08 ,  G21F9/02 ,  G21F9/30

CPC classification number: B01J20/06 ,  B01J20/0222 ,  B01J20/0225 ,  B01J20/0251 ,  B01J20/0259 ,  B01J20/041 ,  B01J20/08 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/30 ,  C02F1/281 ,  C02F1/288 ,  C02F2101/006 ,  G21F9/02 ,  G21F9/12 ,  G21F9/30

Abstract: An adsorbent for a radioelement-containing waste which comprises a spherical layered double hydroxide described in the following (A) or a spherical metal hydroxide described in the following (B): (A) a nonstoichiometric compound represented by the following general formula (a) or (b): [M2+1-xM3+x(OH)2]x+[An-x/n·mH2O]x- .... (a) [Al2Li(OH)6]x+ [An-x/n·mH2O]x- .... (b) wherein 0.1 ≤ x ≤ 0.4, 0

公开(公告)号：EP1676813A4

公开(公告)日：2009-08-12

申请号：EP04723345

申请日：2004-03-25

Applicant: NAT INST FOR MATERIALS SCIENCE

Inventor： TANAKA JUNZO ,  IKOMA TOSHIYUKI ,  TAGUCHI TETSUSHI

IPC: C01B25/32 ,  B01J20/04 ,  B01J20/28 ,  B01J20/282

CPC classification number: B01J20/3204 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3236 ,  B01J20/3272 ,  B01J20/3293 ,  C01B25/32 ,  Y10T428/2982 ,  Y10T428/2991

Abstract: A porous and spherical calcium phosphate particle which is substituted with a metal ion or has a metal ion carried on the surface thereof, and has a particle diameter of 0.1 to 100 µm. The calcium phosphate particle is a novel functional particle which is useful, for example, as a material for use in gas chromatography allowing the separation of a chemical substance of a trace amount with high accuracy.

公开(公告)号：EP2039668A4

公开(公告)日：2012-01-11

申请号：EP07767411

申请日：2007-06-22

Applicant: KURARAY CO ,  NAT INST FOR MATERIALS SCIENCE

Inventor： HOTTA YUJI ,  SUETSUGU YASUSHI ,  KIKUCHI MASANORI ,  IKOMA TOSHIYUKI ,  KUWAYAMA TOMOYA ,  MAKABE TAKASHI ,  TANAKA JUNZO

IPC: C04B38/00 ,  A61L27/00 ,  C04B35/447

CPC classification number: A61L27/56 ,  A61L27/10 ,  A61L2430/02 ,  C04B35/043 ,  C04B35/111 ,  C04B35/447 ,  C04B35/46 ,  C04B35/486 ,  C04B35/565 ,  C04B35/62655 ,  C04B38/0074 ,  C04B2111/00836 ,  C04B2235/3212 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/77 ,  C04B2235/96 ,  C04B2235/9607 ,  Y10T428/249953 ,  Y10T428/249975 ,  C04B38/0003

Abstract: Provision of a porous ceramic material which rapidly induces bone tissue formation and has practical strength. A porous ceramic material 11 having substantially unidirectionally oriented pores 12, a porosity of 40 - 90%, and an average open area of one pore of 0.05×10 -3 - 50×10 -3 mm 2 both in a first sectional surface perpendicular to the pore 12 orientation direction and a second sectional surface parallel to the first sectional surface and 5 mm distant from the first sectional surface in the pore 12 orientation direction. Using the material 11, when a cylindrical test piece (diameter 3 mmxheight 5 mm, the pore 12 array direction as a height direction) made of the material is dipped in polyethylene glycol up to 1 mm from one end thereof, polyethylene glycol permeates through the whole test piece preferably within 30 seconds.

公开(公告)号：EP1825868A4

公开(公告)日：2011-08-10

申请号：EP05793093

申请日：2005-10-13

Applicant: NAT INST FOR MATERIALS SCIENCE ,  HOYA CORP

Inventor： TANAKA JUNZO ,  KIKUCHI MASANORI ,  IKOMA TOSHIYUKI ,  SHOJI DAISUKE ,  KAWAMURA KATSUMI ,  NAKAJIMA TAKEHIKO ,  MOCHIZUKI NAOMI

IPC: A61L27/00 ,  A61F2/28 ,  C04B38/00

CPC classification number: C04B38/0045 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L27/46 ,  A61L27/56 ,  C04B35/447 ,  C04B35/80 ,  C04B2111/00836 ,  Y10T442/692 ,  Y10T442/696 ,  C04B38/0074 ,  C04B14/38 ,  C04B24/14 ,  C04B30/02 ,  C08L89/06

公开(公告)号：CA2479164A1

公开(公告)日：2004-02-05

申请号：CA2479164

申请日：2002-07-25

Applicant: JAPAN SCIENCE & TECH AGENCY ,  NAT INST FOR MATERIALS SCIENCE ,  ESCOM CO LTD ,  TAKI CHEMICAL ,  TAMACHI IND CO LTD

Inventor： FUKUZAKI HIRONOBU ,  SAKANE MASATAKA ,  IKOMA TOSHIYUKI ,  KIKUCHI MASANORI ,  TANAKA JUNZO ,  OTA KUNIHIRO ,  YAMAGUCHI ISAMU ,  YOKOYAMA YOSHIKANE

IPC: A61L27/32 ,  A61L27/36 ,  A61L27/00 ,  A61L31/00

Abstract: An apparatus and a method whereby automation and sterility are ensured in th e practical performance of the alternate immersion method for forming a comple x of a ligament with a calcium phosphate-based compound during an operation at the operation sitein situ within a short time by a small number of workers. An alternate immersion apparatus characterized by being composed of a plural number of containers for supplying chemical solutions; a plural number of infusion tubes which are connected to the respective chemical solution- supplying containers for introducing the chemical solutions into a material immersion container in which a biological sample is treated; a discharge tub e for discharging the chemical solutions from the immersion container; and mea ns of controlling on/off of the infusion tubes and the discharge tube so as to alternately introduce the plural number of chemical solutions into the material immersion container. Using this alternate immersion apparatus where in an aqueous solution containing calcium is employed as one of the chemical solutions and another aqueous solution containing phosphoric acid is employe d as another chemical solution, calcium phosphate complex is formed on the surface and inside of the treated biological material.

公开(公告)号：CA2585577A1

公开(公告)日：2006-05-04

申请号：CA2585577

申请日：2005-10-13

Applicant: PENTAX CORP ,  NAT INST FOR MATERIALS SCIENCE

Inventor： TANAKA JUNZO ,  KIKUCHI MASANORI ,  NAKAJIMA TAKEHIKO ,  KAWAMURA KATSUMI ,  SHOJI DAISUKE ,  IKOMA TOSHIYUKI ,  MOCHIZUKI NAOMI

IPC: A61L27/00 ,  A61F2/28 ,  C04B38/00

Abstract: A method for producing a porous body comprising apatite/collagen composite fibers comprising the steps of gelling a dispersion comprising long apatite/collagen composite fibers having an average length of 10-75 mm, short apatite/collagen composite fibers having an average length of 0.05-1 mm, and a liquid; freezing and drying the resultant gel to form a porous body; and cross-linking collagen in the porous body.