公开(公告)号：JP2012140460A

公开(公告)日：2012-07-26

申请号：JP2012088596

申请日：2012-04-09

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  NAGAI TAKESHI ,  SUGIZAKI YOSHIKI

IPC: A61K47/32 ,  A61K9/70 ,  A61K31/196 ,  A61K47/12 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K9/7061 ,  A61K31/192

Abstract: PROBLEM TO BE SOLVED: To provide a composition for a hydrous adhesive patch for external use which contains a specific amount of an alkyl acrylate ester compound, and to provide an adhesive patch comprising the composition.SOLUTION: The composition for a hydrous adhesive patch for external use comprises an alkyl acrylate ester compound including alkyl acrylate ester as an essential copolymer component and including the other alkyl acrylate ester and/or (meth)acrylic acid as a copolymer component. The composition for a hydrous adhesive patch for external use comprises a water-dispersible surfactant of 0.01 to 10.0 mass% to the whole of the composition for a hydrous adhesive patch for external use.

Abstract translation: 要解决的问题：提供含有特定量的丙烯酸烷基酯化合物的外用含水粘合剂贴剂的组合物，并提供包含该组合物的粘合剂贴剂。 解决方案：用于外用的含水粘合剂贴剂的组合物包含丙烯酸烷基酯化合物，包括丙烯酸烷基酯作为必需共聚物组分，并且包括作为共聚物组分的其它丙烯酸烷基酯和/或（甲基）丙烯酸。 用于外用的含水粘合剂贴剂的组合物包含用于外用含水粘合剂贴剂的整个组合物的0.01至10.0质量％的水分散性表面活性剂。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：HK1103965A1

公开(公告)日：2008-01-04

申请号：HK07108245

申请日：2007-07-27

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SAITOH TAKASHI

IPC: A61K20060101 ,  A61K9/70 ,  A61K31/137 ,  A61P20060101

Abstract: The present invention provides a tulobuterol adhesive patch comprising (a) a support, (b) an acrylic pressure-sensitive adhesive layer containing the percutaneously absorbing drug tulobuterol and if necessary a lipophilic oily plasticizer, and (c) a release liner, laminated in that order, wherein the acrylic pressure-sensitive adhesive is a copolymer obtained by copolymerizing an acrylic monomer which is acetoacetoxyalkyl (meth) acrylate with one or more other vinyl monomers, to yield a tulobuterol adhesive patch with excellent release and skin permeability of tulobuterol from the pressure-sensitive adhesive layer, low skin irritation and excellent safety.

公开(公告)号：JP2013227355A

公开(公告)日：2013-11-07

申请号：JP2013168530

申请日：2013-08-14

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SUGAYA CHIE ,  SAKURAI NORIAKI

IPC: A61K31/192 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61K47/44 ,  A61K47/46 ,  A61P29/00

CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/405

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for external application and an adhesive skin patch capable of improving releasability, transdermal absorbability and stability of loxoprofen and a salt thereof and capable of reducing aggravation of irritation to skin.SOLUTION: An adhesive skin patch includes a support and an adhesive layer laminated on the support. The adhesive layer includes a styrene-isoprene-styrene copolymer, a tackifier, a plasticizer, sodium loxoprofen, oxyacid and N-methyl-2-pyrrolidone. Preferably, the adhesive layer includes no crotamiton.

Abstract translation: 要解决的问题：提供一种用于外用的药物组合物和能够改善洛索洛芬及其盐的脱皮能力，经皮吸收性和稳定性的粘合性皮肤贴剂，并且能够减轻对皮肤刺激的加重。解决方案：粘合性皮肤贴剂包括 支撑体和层压在支撑体上的粘合剂层。 粘合层包括苯乙烯 - 异戊二烯 - 苯乙烯共聚物，增粘剂，增塑剂，洛索洛芬钠，含氧酸和N-甲基-2-吡咯烷酮。 优选地，粘合剂层不包括克罗他米通。