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    PHARMACEUTICAL COMPOSITION FOR EXTERNAL APPLICATION AND ADHESIVE SKIN PATCH
    1.
    发明专利
    PHARMACEUTICAL COMPOSITION FOR EXTERNAL APPLICATION AND ADHESIVE SKIN PATCH 未知

    公开(公告)号：CA2671636A1

    公开(公告)日：2008-06-12

    申请号：CA2671636

    申请日：2007-12-06

    Applicant: NIPRO PATCH CO LTD

    Inventor： TSUCHIYA JUNKO ,  KAWAMURA NAOHISA ,  SAITOH TAKASHI ,  SUGAYA CHIE

    IPC: A61K9/70 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/405 ,  A61K47/10 ,  A61K47/12 ,  A61K47/22 ,  A61K47/32 ,  A61K47/44

    Abstract: Disclosed are a pharmaceutical composition for external application, an a dhesive skin patch and others which are improved in a drug release property, transdermal absorbability and stability of a pharmacologically active ingre dient contained therein and can reduce the aggravation of irritation to the skin. Specifically disclosed is an adhesive skin patch comprising a support and an adhesive layer laminated on the support, wherein the adhesive layer c ontains a pharmaceutical composition for external application. The pharmaceu tical composition for external application comprises a pharmacologically act ive ingredient, an auxiliary component and a pyrrolidone compound, wherein o ne of the pharmacologically active ingredient and the auxiliary component ha s a carboxylate group in the molecule and the other has a hydroxy group in t he molecule. Preferably, the adhesive layer further comprises a hydrogenated oil.

    ADHESIVE SKIN PATCH AND METHOD FOR EVALUATION OF ADHESIVE SKIN PATCH
    2.
    发明专利
    ADHESIVE SKIN PATCH AND METHOD FOR EVALUATION OF ADHESIVE SKIN PATCH 未知

    公开(公告)号：CA2670971A1

    公开(公告)日：2008-06-05

    申请号：CA2670971

    申请日：2007-11-29

    Applicant: NIPRO PATCH CO LTD

    Inventor： KAWAMURA NAOHISA ,  SAITOH TAKASHI ,  TSUCHIYA JUNKO

    IPC: A61K47/32 ,  A61K9/70

    Abstract: Disclosed is an adhesive skin patch having an SIS block copolymer as an a dhesive component, which has an improved handling property and can reduce ir ritation to a user. The adhesive skin patch comprises a flexible substrate a nd an adhesive layer laminated on the substrate, wherein the adhesive layer comprises a styrene-isoprene-styrene block copolymer. In the adhesive skin p atch, the tan.delta. value of the adhesive agent as determined by measuring a dynamic viscoelasticity at 32ºC satisfies a requirement represented by the following formula 1 at at least one frequency laying between 0.04 to 0.25 H z. 0.25x + 0.05

    Percutaneous absorption promoter, skin treatment agent and percutaneous absorption-type pharmaceutical preparation containing the same
    3.
    发明专利
    Percutaneous absorption promoter, skin treatment agent and percutaneous absorption-type pharmaceutical preparation containing the same 有权
    PERCUTANEOUS吸收促进剂，皮肤治疗剂和含有其的PERCUTANEOUSO吸收型药物制剂

    公开(公告)号：JP2009235065A

    公开(公告)日：2009-10-15

    申请号：JP2009048952

    申请日：2009-03-03

    Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

    Inventor： KAWAMURA NAOHISA ,  TSUCHIYA JUNKO

    IPC: A61K47/14 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/12 ,  A61K9/70 ,  A61K31/137

    Abstract: PROBLEM TO BE SOLVED: To provide a percutaneous absorption promotor stimulating percutaneous absorption of a drug and containing a highly safe higher fatty acid triglyceride with less irritation to the skin, and to provide a skin treatment pharmaceutical preparation and the percutaneous absorption type pharmaceutical preparation, containing the higher fatty acid glyceride. SOLUTION: This percutaneous absorption promotor contains a higher fatty acid triglyceride of 14C or more and can stimulate percutaneous absorption of a drug by application before use of a medicant drug. In addition, the skin treatment pharmaceutical preparation and the percutaneous absorption type pharmaceutical preparation are components constructing human sebum, thus are low irritant to the skin and excellent in safety. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：提供刺激药物的经皮吸收并含有对皮肤刺激性低的高度安全的高级脂肪酸甘油三酯的经皮吸收促进剂，并提供皮肤治疗药物制剂和经皮吸收型药物 制备，含有高级脂肪酸甘油酯。 解决方案：该经皮吸收促进剂含有14℃或更高的高级脂肪酸甘油三酯，并且可以在使用药物之前通过施用来刺激药物的经皮吸收。 此外，皮肤治疗药物制剂和经皮吸收型药物制剂是构成人类皮脂的成分，因此对皮肤的刺激性低，安全性优异。 版权所有（C）2010，JPO＆INPIT

    SKIN PATCH
    4.
    发明专利
    SKIN PATCH 未知

    公开(公告)号：HK1115323A1

    公开(公告)日：2008-11-28

    申请号：HK08110847

    申请日：2008-09-29

    Applicant: NIPRO PATCH CO LTD

    Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SAITOH TAKASHI ,  TAKIZAWA CHIHIRO ,  TSUCHIYA JUNKO

    IPC: A61K20060101

    Abstract: A skin patch that can enhance the water resistance and handling easiness and can alleviate any irritation on the user. There is provided a skin patch comprising a flexible backing and, superimposed thereon, a plaster layer wherein the plaster layer contains a styrene-isoprene-styrene block copolymer and has a glass transition temperature (Tg) of -45° to -35°C and a tan ´ (lag angle) value, determined at dynamic viscoelasticity measurement (frequency 6.2832 rad/s) at 45°C, of 0.25 or less.

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