公开(公告)号：EP1346981B1

公开(公告)日：2006-05-10

申请号：EP01912138.3

申请日：2001-03-07

Applicant: National Institute of Advanced Industrial Science and Technology

Inventor： HATAKEDA, Kiyotaka ,  SATO, Osamu ,  KANAKUBO, Mitsuhiro, c/o AIST, Tohoku ,  IKUSHIMA, Yutaka ,  TORII, Kazuo

IPC: C07D201/08 ,  C07D205/08

CPC classification number: C07D201/08 ,  Y02P20/582

Abstract: A process for synthesizing a β-lactam in water at a high temperature under a high pressure; and a process for producing a β-lactam. Namely, a process for synthesizing a ß-lactam characterized by reacting aβ-amino acid in water at a high temperature under a high pressure, wherein the β-lactam is synthesized at a high rate by cyclizing the β-amino acid in water at a high temperature of 200 °C or more under a high pressure of 10 Mpa or more; and a process for producing a β-lactam characterized by synthesizing the β-lactam by reacting a β-amino acid in water at a high temperature under a high pressure and then separating and purifying the β-lactam with the use of a column separating agent.

公开(公告)号：EP1369413A1

公开(公告)日：2003-12-10

申请号：EP01914201.7

申请日：2001-03-23

Applicant: National Institute of Advanced Industrial Science and Technology

Inventor： HATAKEDA, Kiyotaka ,  SATO, Osamu ,  IKUSHIMA, Yutaka ,  TORII, Kazuo

IPC: C07D201/04 ,  C07D223/10

CPC classification number: C07D201/06 ,  C07D201/04 ,  C07D223/10

Abstract: A process for continuously producing a lactam in water at a high temperature under a high pressure. Namely, a process for producing a lactam characterized by selectively synthesizing the lactam without causing hydrolysis by introducing an oxime into flowing water at a high temperature under a high pressure, wherein the lactam is continuously synthesized at a high rate from the oxime in water at a high temperature of 250 °C or more under a high pressure of 12 Mpa or more.

Abstract translation: 一种在高温下在高压下连续生产内酰胺的方法。 即，制造内酰胺的方法，其特征在于，通过在高温下将肟引入流动的水中而不引起水解而选择性合成内酰胺，其中内部酰胺以高的速率从肟在水中以 高温250℃以上，高压12Mpa以上。

公开(公告)号：EP1336603A1

公开(公告)日：2003-08-20

申请号：EP01978942.9

申请日：2001-10-30

Applicant: National Institute of Advanced Industrial Science and Technology

Inventor： HATAKEDA, Kiyotaka ,  IKUSHIMA, Yutaka ,  SATO, Osamu ,  KAWANAMI, Hajime ,  KANAKUBO, Mitsuhiro ,  TORII, Kazuo

IPC: C07C229/24 ,  C07C227/08 ,  C07C227/40 ,  C07C229/08

CPC classification number: C07C227/40 ,  C07C227/08 ,  C07C229/08 ,  C07C229/24 ,  C07C229/26

Abstract: The present invention relates to a method for introducing an amino group into an organic acid by reacting the organic acid and ammonia under high-temperature and high-pressure water conditions, a method for synthesizing an amino acid by reacting an organic acid and ammonia under high-temperature and high-pressure water conditions, and thereby introducing amino group into the organic acid to synthesize an amino acid, and a method for manufacturing an amino acid by reacting an organic acid and ammonia under high-temperature and high-pressure water conditions, thereby introducing an amino group into the organic acid to synthesize an amino acid, and then separating and refining it with an ion exchange resin.

Abstract translation: 本发明涉及一种用于通过使对在高有机酸和氨通过使高温高压水的条件下，为的氨基酸合成的方法下的有机酸和氨在氨基基团引入到上有机酸 - 温度和高压水的条件下，并由此引入氨基入有机酸在合成氨基酸，以及一种用于制造的氨基酸通过使上高温和高压水的条件下的有机酸和氨 从而引入氨基的入有机酸在合成氨基酸，然后分离，并用离子交换树脂精制它。

公开(公告)号：EP1346981A1

公开(公告)日：2003-09-24

申请号：EP01912138.3

申请日：2001-03-07

Applicant: National Institute of Advanced Industrial Science and Technology

Inventor： HATAKEDA, Kiyotaka ,  SATO, Osamu ,  KANAKUBO, Mitsuhiro ,  IKUSHIMA, Yutaka ,  TORII, Kazuo

IPC: C07D201/08 ,  C07D205/08

CPC classification number: C07D201/08 ,  Y02P20/582

Abstract: It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the present invention relates to a β-lactam synthesis method which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that β-lactams are synthesized at a high speed by cyclizing β-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200°C or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing β-lactams which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.

Abstract translation: 本发明的目的是提供一种合成β-内酰胺的方法和在高温和高压水中制备β-内酰胺的方法，本发明涉及β-内酰胺合成方法 其特征在于通过β-氨基酸在高温和高压下在水中反应来合成β-内酰胺，该方法的进一步特征在于通过使β-氨基酸在高温和高压下环化β-氨基酸来合成β-内酰胺 在温度范围为200℃以上且压力范围为10MPa以上的高温高压下的水，本发明还涉及β-内酰胺的制造方法，其特征在于， β-内酰胺通过在高温和高压下在水中使β-氨基酸反应合成，然后使用柱分离介质分离和纯化。

公开(公告)号：EP1312611A1

公开(公告)日：2003-05-21

申请号：EP00977971.1

申请日：2000-11-28

Applicant: National Institute of Advanced Industrial Science and Technology

Inventor： HATAKEDA, Kiyotaka ,  IKUSHIMA, Yutaka ,  MARUYAMA, Susumu ,  TORII, Kazuo

IPC: C07K1/12 ,  C07C229/02 ,  C07C227/18 ,  A23J3/30 ,  A23L1/305 ,  G01N33/68

CPC classification number: C07K1/12 ,  A23J3/30 ,  A23L33/175 ,  A23L33/18 ,  C07C227/18 ,  C07C227/28 ,  Y02P20/544 ,  C07C229/02

Abstract: The present invention is aimed at providing a method for degrading protein into peptides and/or amino acids continuously and at a high rate in supercritical water or high-pressure hot water at near-supercritical point, and the method of the present invention related to a method for continuously hydrolyzing a substrate protein introduced into a reactor and manufacturing peptides and/or amino acids using a flow reactor which contains as constituent elements thereof a substrate introduction line for supplying a substrate, a preheating furnace for supplying high-temperature hot water, a reactor for heating and reacting a reaction solution, and a cooling unit for cooling the reaction solution, wherein the peptides and/or amino acids are manufactured from the protein continuously and at a high rate by means of continuous reaction in supercritical water or high-pressure hot water at near-supercritical point at a pressure of 22.05 MPa or greater and a temperature of 375°C or greater; and relates to a method for hydrolyzing protein by the abovementioned steps continuously and at a high rate, and is especially useful as a method for manufacturing physiologically active peptides and a preprocessing method or the like for evaluative analysis of amino acid compositions because of the ability to yield a preparation that has very few secondary and tertiary reaction products and is fundamentally different from a product obtained by a batch method.

Abstract translation: 本发明的目的在于提供一种在超临界点的超临界水或高压热水中连续地以高速率将蛋白质降解为肽和/或氨基酸的方法，本发明的方法涉及 使用流动反应器连续水解引入反应器的底物蛋白质的方法，并且使用流动反应器制造肽和/或氨基酸，所述流动反应器包含作为其基材的供给用基材引入线的构成要素，用于供给高温热水的预热炉， 用于加热和反应反应溶液的反应器和用于冷却反应溶液的冷却单元，其中肽和/或氨基酸通过在超临界水或高压下的连续反应连续地和以高速率由蛋白质制备 接近超临界点的热水在22.05MPa或更高的压力和375℃或更高的温度下; 涉及通过上述步骤连续高速地水解蛋白质的方法，特别是作为制造生理活性肽的方法和用于氨基酸组成的评价分析的预处理方法等，因为其能够 得到二次和三次反应产物非常少的制剂，与通过间歇法获得的产品基本不同。