公开(公告)号：EP3018480A4

公开(公告)日：2017-02-08

申请号：EP14819349

申请日：2014-04-15

Applicant: OLYMPUS CORP

Inventor： TAKEICHI RIE ,  MORIYA NAO ,  SANUKI HIROMI ,  NAKATA MARI ,  KIYOHARA MASANOBU ,  TAKEYAMA TETSUHIDE ,  NAGAOKA TOMONORI

IPC: G01N33/72 ,  A61B5/00 ,  A61B5/103 ,  A61B10/00 ,  G01J3/42 ,  G01J3/46 ,  G01N21/29 ,  G01N21/31 ,  G01N33/48 ,  G01N33/50 ,  G01N33/52 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57438 ,  A61B5/1032 ,  A61B5/4283 ,  A61B2010/0061 ,  G01N21/29 ,  G01N21/293 ,  G01N21/31 ,  G01N33/48 ,  G01N33/6872 ,  G01N2333/70503 ,  G01N2800/067

Abstract: Provided are a method for exclusively selecting a duodenal fluid sample having a high possibility of containing pancreatic fluid and favorable sample suitability for subjecting to detection of a pancreatic disease marker by evaluating the quality of the sample prior to detecting the pancreatic disease marker, and a method for detecting a pancreatic disease marker using a duodenal fluid sample selected according to that method. Namely, a method is provided for selecting a duodenal fluid sample for detecting a pancreatic disease marker, comprising: (a1) a step of comparing the color depth of a duodenal fluid sample with a prescribed standard color, and (b1) a step of determining that a duodenal fluid sample is subjected to a test for a pancreatic disease marker if the color depth thereof is equal to or higher than the standard color, but that the duodenal fluid sample is not subjected to a test for a pancreatic disease marker if the color depth thereof is lower than the standard color.

公开(公告)号：JP2011147664A

公开(公告)日：2011-08-04

申请号：JP2010012456

申请日：2010-01-22

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: A61F2/84 ,  A61M29/00 ,  A61M31/00

Abstract: PROBLEM TO BE SOLVED: To provide a catheter and a catheter set which can stabilize the discharge position of a drug or the like and stabilize administration of the drug or the like. SOLUTION: The catheter 3, with which living tissue of a mammal including a human is punctured, which is provided with a long and thin structure 8 has a lumen 9 inside and in which an opening 10 communicating with the lumen 9 is formed, and an expandable stent 5 which is arranged at the end of the structure 8. The end of the catheter 3 is stably fixed and is allowed to indwell in a target of drug administration in the living tissue by expanding the stent 5. Since the distance between the end of the catheter 3 and the tissue of the target of drug administration can be also increased, the drug or the like can be stably administered. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供可以稳定药物等的排出位置并稳定药物等的给药的导管和导管组。 解决方案：设置有长而薄的结构8的哺乳动物包括人的生物组织的导管3在内部具有内腔9，其中形成有与内腔9连通的开口10 ，以及布置在结构8的端部的可扩张支架5.导管3的端部被稳定地固定，并且通过扩张支架5而允许在活体组织中的药物给药目标中。由于距离 在导管3的端部与给药用靶组织之间也可以增加，能够稳定地施用药物等。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010125226A

公开(公告)日：2010-06-10

申请号：JP2008305499

申请日：2008-11-28

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU ,  KIMURA KAYU

IPC: A61M31/00 ,  A61M25/00

Abstract: PROBLEM TO BE SOLVED: To provide a catheter which can easily and surely administer a medicine to a specified region in a vicinity of the surface of an intracorporeal organ. SOLUTION: This catheter 10 which is attached to the intracorporeal organ 4 of mammalians including human being includes: a flexible sheet section 1 at least a part of the rear surface of which is closely joined to the surface of the intracorporeal organ 4; and a flexible tube 2 which is extended from the surface of the sheet section 1. On the rear surface of the sheet section 1, an opening 12 which communicates with the internal passage of the tube 2 is installed. On the rear surface of the sheet section 1, a closely joining region 21 which is closely joined to the organ surface 8, and a non-joining region 22 which is not closely joined to the organ surface 8 are formed. The opening 12 is installed in the non-joining region 22, and a vacant chamber 23 is formed. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种可以容易且可靠地将药物施用于体内器官表面附近的特定区域的导管。 解决方案：连接到包括人的哺乳动物的体内器官4的该导管10包括：柔性片段1，其后表面的至少一部分紧密结合到体内器官4的表面; 以及从片部1的表面延伸的柔性管2.在片部1的后表面上安装有与管2的内部通路连通的开口12。 在片部1的后表面形成有与器官面8紧密结合的紧密接合区域21和与器官面8不接合的非接合区域22。 开口12安装在非接合区域22中，并且形成空腔室23。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2008020312A

公开(公告)日：2008-01-31

申请号：JP2006192094

申请日：2006-07-12

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: G01N35/00

Abstract: PROBLEM TO BE SOLVED: To provide an output method for displaying an inspection result constituted so as not to lose traceability even in a state that the inspection result is derived through a complicated processing route when various processing devices or processing kits are combined to perform inspection without introducing an expensive full automatic inspection device. SOLUTION: In the output method of the inspection result in an inspection result processor for acquiring target data from a biological specimen by stepwise performing a plurality of biological and biochemical reaction operations with respect to the biological specimen acquired from a target person in the inspection of the specimen, the processing units set to the respective processes of the reaction operations are stored, and the inspection items of the biological specimen in the reaction operations and the inspection results derived by the reaction operations are acquired in the respective processes and allowed to correspond to each other to be stored in a memory device. The respective processes and inspection results stored in the memory device and the stored processing units are related with each other to be output to an output device. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种输出方法，用于显示即使在将各种处理装置或处理套件组合到一起时通过复杂的处理路线导出检查结果的状态下也不会失去追踪的构造的检查结果 执行检查而不引入昂贵的全自动检测装置。 解决方案：在检查结果处理器的检查结果的输出方法中，通过对从生物样本中的目标人员获取的生物样本进行多个生物和生化反应操作，从生物样本获取目标数据， 存储样本的检查，设定为反应操作的各个处理的处理单元，并且在各个处理中获取生物样本在反应操作中的检查项目和由反应操作得到的检查结果，并允许 彼此对应地存储在存储装置中。 存储在存储装置和存储的处理单元中的各个处理和检查结果彼此相关，以被输出到输出装置。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2012020105A

公开(公告)日：2012-02-02

申请号：JP2010287564

申请日：2010-12-24

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: A61M25/01

Abstract: PROBLEM TO BE SOLVED: To provide a catheter for smoothing the medication to a tumor of a medication object by decreasing an influence that obstructs the medication of a fiber stroma included in the tumor without influencing the other tissues except the tumor of the medication object.SOLUTION: The catheter 1 includes: an elongated skeleton 2 which has a lumen 5 thereinside; a wire 3 which is installed in a site of the catheter 1 to be introduced in a living tissue 19 and incises the living tissue 19; a slider 8 which operates the wire 3 to displace at least a portion of wire 3 in a direction spaced away from the skeleton 2; and a wire rod 4.

Abstract translation: 要解决的问题：提供一种用于通过减少妨碍包括在肿瘤中的纤维基质的药物的影响而不影响除药物肿瘤之外的其它组织的用于将药物平滑化为药物对象的肿瘤的导管 目的。 解决方案：导管1包括：细长骨架2，其内侧具有内腔5; 电线3，其安装在导入管1的位置，导入生物体组织19并切开生物体组织19; 滑块8，其操作线3以沿着与骨架2间隔开的方向移位线3的至少一部分; 和线材4.版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2011147663A

公开(公告)日：2011-08-04

申请号：JP2010012455

申请日：2010-01-22

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: A61M31/00

Abstract: PROBLEM TO BE SOLVED: To provide a catheter, and a medicine administration device, capable of correctly administrating a minute quantity of medicine. SOLUTION: The device includes a catheter 3 to administer medicine as pierced into a living body tissue of a mammal such as a human, which is a thin and long member 8 having a lumen 9 inside and a through hole 10 to connect the lumen 9 to the external, a non-transparent elastic sheet 11 covering the through hole 10, and a pressure-permeable hard outer member 12 which covers the through hole 10 from the outer side of the non-transparent elastic sheet 11 and to which the chemical is permeable in a pressurized state. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供能够正确地施用微量药物的导管和药剂管理装置。 解决方案：该装置包括导管3，用于将药物刺入诸如人的哺乳动物的活体组织中，所述哺乳动物是具有内腔9的细长的构件8和通孔10，以连接 内腔9连接到外部，覆盖通孔10的不透明弹性片11以及从非透明弹性片11的外侧覆盖通孔10的透气性硬质外部构件12， 化学品在加压状态下是可渗透的。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010252926A

公开(公告)日：2010-11-11

申请号：JP2009104531

申请日：2009-04-22

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: A61M25/00

Abstract: PROBLEM TO BE SOLVED: To provide a catheter capable of preventing turn of the catheter about the axis when having at least a single discharge hole on the side face. SOLUTION: This catheter 1 whose distal end 4, at least, is inserted into a living body, includes an elongated tube 2 which has the distal end 4 having at least the single discharge hole on the side face and a body section 3 located at the proximal end side with respect to the distal end 4, and at least a part of the distal end 4 is provided with a turning prevention section 5 which has a shape preventing the turning about the axis, with the distal end 4 inserted in the living body. The turning prevention section 5 is a part where at least a part of the distal end 4 is curved, and the curve generates a resistance to the turning of the catheter 1 about the axis to prevent the turning. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供一种导管，当能够在侧面具有至少一个排出孔时能够防止导管绕轴线转动。 解决方案：其前端4至少插入生物体中的该导管1包括细长管2，其具有至少在侧面上的单个排出孔的远端4和主体部3 位于远端4的近端侧，远端4的至少一部分设置有防止转动的形状的转动防止部5，其中前端4插入 活体。 转向防止部5是远端4的至少一部分弯曲的部分，并且曲线产生对导管1绕轴线的转动的阻力，以防止转动。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010125227A

公开(公告)日：2010-06-10

申请号：JP2008305500

申请日：2008-11-28

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIMURA KAYU ,  KIYOHARA MASANOBU

IPC: A61M31/00 ,  A61M25/00

Abstract: PROBLEM TO BE SOLVED: To provide a catheter easily and reliably administering a pharmaceutical to a predetermined area in the vicinity of the surface of an internal organ. SOLUTION: This catheter 10, to be attached to the internal organ 4 of the mammal including a human, includes a supporter section 1 whose back surface at least partially adheres to the surface of the internal organ 4, and which is flexible at least partially, and a flexible tube 2 which extends from the surface of the supporter section 1. The supporter section 1 is positioned and fixed to the internal organ 4 as if wrapping the internal organ 4, the back surface of the supporter section 1 has an opening 12 communicated with an internal path of the tube 2, the back surface of the supporter section 1 is formed with an adhesion area adhering to the surface of the internal organ 4, and a non-adhesion area formed of a connection section 11 and non-adhering to the surface of the internal organ 4, and the pharmaceutical is administered from the non-adhesion area. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：为了将导管容易且可靠地供给到内脏器官表面附近的规定区域，提供导管。 <！ - SIPO - >解决方案：附接到包括人的哺乳动物的内脏器官4的该导管10包括支撑部分1，其支撑部分1的后表面至少部分地粘附于内脏器官4的表面， 至少部分地以及从支撑部1的表面延伸的柔性管2.支撑部1定位并固定到内脏4，如同包裹内脏器官4一样，支撑部1的背面具有 开口12与管2的内部通路连通，支撑部1的背面形成有附着在内脏4的表面上的粘附区域，以及由连接部11和非连接部11形成的非粘合区域 - 粘附于内脏器官4的表面，并且药物从非粘附区域施用。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2015011011A

公开(公告)日：2015-01-19

申请号：JP2013138847

申请日：2013-07-02

Applicant: オリンパス株式会社 ,  Olympus Corp ,  オリンパスメディカルシステムズ株式会社 ,  Olympus Medical Systems Corp

Inventor： KATAOKA RIE ,  MORIYA NAO ,  SANUKI HIROMI ,  NAKAMOTO MARI ,  KIYOHARA MASANOBU ,  TAKEYAMA TETSUEI

IPC: G01N33/52 ,  G01J3/46 ,  G01N21/27 ,  G01N33/68

Abstract: 【課題】同一被検者から採取された複数の十二指腸液試料から、膵液が含まれている可能性が高く、膵疾患マーカー検出により適した試料を選定する方法、及び当該方法により選定された十二指腸液試料を用いて膵疾患マーカーを検出する方法の提供。【解決手段】(a)同一被検者から採取された複数の十二指腸液試料の色の濃さを比較する工程と、(b)前記工程(a)の結果に基づき、前記複数の十二指腸液試料の中から最も色の濃い試料を、当該膵疾患マーカーの検査に供する試料として選定する工程と、を有することを特徴とする、膵疾患マーカー検出用十二指腸液試料の選定方法。【選択図】なし

Abstract translation: 要解决的问题：提供一种用于从相同测试对象收集的多个十二指肠液体样品中选择极有可能含有胰液的样品的方法，并且更适合于检测胰腺疾病标记物，并且提供 一种通过使用由该方法选择的十二指肠液标本检测胰腺疾病标记物的方法。解决方案：一种选择胰腺疾病标记物检测十二指肠液样品的方法包括以下步骤：（a）比较多个十二指肠的颜色浓度 从同一受试者收集的流体标本; 和（b）基于上述步骤（a）的结果，从多个十二指肠液体样本中选择用于检测胰腺疾病标记物的样本的最大颜色浓度。

公开(公告)号：JP2012000143A

公开(公告)日：2012-01-05

申请号：JP2010135264

申请日：2010-06-14

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: A61M5/14 ,  A61M25/00

Abstract: PROBLEM TO BE SOLVED: To provide a drug administration needle that can smoothly adminiostrate a drug regardless of degrees of stiffness of the tissue of a living body as an administration target.SOLUTION: The drug administration needle 1 includes: an elongate outer cylinder 2 having a lumen 4 inside; an end portion 7 where a pointed stick portion 6 is formed; and an elongate shaft portion 8 located on a proximal end side that is away from the end portion 7. At least the elongate shaft portion 8 includes: an inner needle 3 that is movably inserted into the lumen 4 of the outer cylinder 2 in a shaft direction and whose entire length is longer than the outer cylinder 2; and a drug infusion port 10 for infusing the drug into a space 41 between the inner surface of the outer cylinder 2 and the shaft portion 8 of the inner needle 3.

Abstract translation: 要解决的问题：提供一种能够顺利地管理药物的药物给药针，而不管生物体的组织的硬度如何作为给药目标。 药物给药针1包括：内部具有内腔4的细长外筒2; 形成尖头部6的端部7; 以及位于远离端部7的近端侧的细长轴部8.至少细长轴部8包括：内针3，其以可动方式插入到外筒2的内腔4中的轴 并且其整个长度比外筒2长; 以及用于将药物注入到外筒2的内表面和内针3的轴部8之间的空间41中的药物注入口10.版权所有（C）2012，JPO＆INPIT