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公开(公告)号：US20170010453A1
公开(公告)日：2017-01-12
申请号：US15275359
申请日：2016-09-24
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO , Shinichi TAKIMOTO , Shintaro TAKAHASHI , Atsushi DOI
CPC classification number: G02B21/0076 , G01N21/6458 , G01N2201/06113 , G01N2201/1053 , G01N2201/12 , G02B21/0032 , G02B21/006 , G02B21/0068 , G02B21/008 , G02B21/0084
Abstract: Provided is a microscope provided with: a scanner that scans an excitation beam coming from a light source; an objective optical system that focuses the scanned excitation beam onto a sample and that collects fluorescence generated at individual scanning positions in the sample; a detector that detects the collected fluorescence; a light blocking member that is disposed between the detector and the system and that partially blocks the collected fluorescence; a switching portion that switches the positional relationship between the member and a light-focusing point of the excitation beam in the sample between an optically conjugate positional relationship, in which an in-focus fluorescence generated at the light-focusing point passes through the member, and a non-conjugate positional relationship, in which the in-focus fluorescence is blocked by the member; and a computing portion that computes a difference between fluorescence signals acquired by the detector in the two positional relationships.
Abstract translation: 提供了一种显微镜，其具有：扫描来自光源的激发光束的扫描仪; 物镜光学系统，其将扫描的激发光束聚焦到样品上并且收集样品中各个扫描位置产生的荧光; 检测所收集的荧光的检测器; 光阻挡构件，其设置在所述检测器和所述系统之间并部分阻挡所述收集的荧光; 切换部，其以在所述光聚合点处产生的聚焦荧光透过所述构件的光学共轭位置关系之间切换所述构件与所述样品中的所述激发光束的聚光点之间的位置关系， 以及非共轭位置关系，其中聚焦荧光被构件阻挡; 以及计算部分，其计算由两个位置关系中的检测器获取的荧光信号之间的差异。
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公开(公告)号：US20210204817A1
公开(公告)日：2021-07-08
申请号：US17207019
申请日：2021-03-19
Applicant: OLYMPUS CORPORATION
Inventor： Yoshiaki MURAYAMA , Atsushi DOI , Kentaro IMOTO
IPC: A61B5/00
Abstract: A photoacoustic imaging device includes an excitation light irradiation unit that irradiates the same position of a specimen with two or more beams of pulsed excitation light separated by an irradiation time interval, a detector that detects an acoustic wave generated at the position irradiated with the excitation light by the excitation light irradiation unit, a generator that generates an image of the specimen based on the detected acoustic wave, and a controller that controls the irradiation time interval, the acoustic wave generated with a single beam of pulsed excitation light has multiple positive peaks that periodically occur, and the controller controls the irradiation time interval into a timing at which a second positive peak of the acoustic wave generated with the preceding excitation light is superimposed on a first positive peak of the acoustic wave generated with the subsequent excitation light.
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公开(公告)号：US20190113459A1
公开(公告)日：2019-04-18
申请号：US16215809
申请日：2018-12-11
Applicant: OLYMPUS CORPORATION
Inventor： Asuka SUEKANE , Shintaro TAKAHASHI , Kentaro IMOTO , Atsushi DOI , Shinichi TAKIMOTO
IPC: G01N21/64
CPC classification number: G01N21/6458 , G01N21/6428 , G01N35/00 , G01N35/00722 , G01N2035/00891 , G01N2201/12
Abstract: An observation assistance device of the present invention includes: an information storage unit that stores sample state information showing a sample state change, a type of sample, a type of fluorescent substance, and an observation condition in fluorescence observation performed on a predetermined sample, and under a predetermined observation condition; an input unit via which inputs the type of sample to be observed and the type of fluorescent substance to be used; an assistance-display generating unit that reads sample state information and an observation condition of fluorescence observation performed on the same type of sample as the type of sample input, using the same type of fluorescent substance as the type of fluorescent substance, and generates an assistance display showing the sample state information in relation to the two or more parameters included in the observation condition; and a display unit that displays the generated assistance display.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20180373010A1
公开(公告)日：2018-12-27
申请号：US16059453
申请日：2018-08-09
Applicant: OLYMPUS CORPORATION
Inventor： Atsushi DOI
IPC: G02B21/00 , H01J37/28 , H01J37/285
Abstract: A point-spread-function measurement device includes: a scanner that scans two illumination light beams emitted from a light source; an illumination optical system that radiates the two illumination light beams scanned by the scanner onto a sample; a relative-position adjustor that changes a relative irradiation position, in the sample, between the two illumination light beams radiated by the illumination optical system; a detection optical system that detects signal light generated at an overlapping position, in the sample, of the illumination light beams radiated by the illumination optical system; and a calculator that calculates a point spread function based on the signal light detected by the detection optical system and the relative irradiation position between the two illumination light beams when the signal light is detected.
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公开(公告)号：US20210208109A1
公开(公告)日：2021-07-08
申请号：US17207897
申请日：2021-03-22
Applicant: OLYMPUS CORPORATION
Inventor： Yoshiaki MURAYAMA , Atsushi DOI , Kentaro IMOTO
Abstract: A photoacoustic imaging device includes an irradiator irradiating a specimen with excitation light, a detection unit detecting an acoustic wave at an irradiated position, a propagation body including a bag-shaped body including a film deforming in conformity with a surface shape of the specimen, an interior of the bag-shaped body being filled with an acoustic wave propagation medium, and a processor including hardware and configured to generate an image based on the detected acoustic wave, wherein the propagation body is disposed between the detection unit and the specimen, without interposing any air layers, and moves along with relative movement of the detection unit and the specimen, the detection unit includes an optics collecting the acoustic wave, the propagation body is attached to the optics, and a difference of refractive indexes between the optics and the propagation body is smaller than a difference of refractive indexes between the optics and air.
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公开(公告)号：US20180373011A1
公开(公告)日：2018-12-27
申请号：US16118705
申请日：2018-08-31
Applicant: OLYMPUS CORPORATION
Inventor： Atsushi DOI
Abstract: An image acquisition method in which a pulsed illumination beam emitted from a light source is scanned while being focused at a sample, signal light generated as a result of a non-linear optical process at each scanning position is detected, and an image of the sample is generated on a basis of the detected signal light, the image acquisition method including: acquiring a mixed image, which includes in-focus signal light generated at a focal position of the illumination beam in the sample and which also includes out-of-focus signal light; acquiring an image of the out-of-focus signal light on a basis of a plurality of mixed images having mutually different intensities of the out-of-focus signal light; and acquiring an image of the in-focus signal light by subtracting the image of the out-of-focus signal light acquired, from the mixed image acquired.
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公开(公告)号：US20180059397A1
公开(公告)日：2018-03-01
申请号：US15683980
申请日：2017-08-23
Applicant: OLYMPUS CORPORATION
Inventor： Tatsuo NAKATA , Atsushi DOI , Kentaro IMOTO
CPC classification number: G02B21/0032 , G02B21/0044 , G02B21/0048 , G02B21/06 , G02B21/24
Abstract: Provided is a microscope system including: an objective lens that focuses, on a specimen, illumination light produced by a light source; an illumination-area switching mechanism that is disposed between the objective lens and the specimen and that switches an illumination area irradiated with the illumination light focused by the objective lens among a plurality of illumination areas on the specimen that are located outside the objective optical axis of the objective lens; and an inner focus lens that is disposed on the objective optical axis between the light source and the objective lens and that changes the focus position of the objective lens in the direction along the objective optical axis.
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公开(公告)号：US20190387963A1
公开(公告)日：2019-12-26
申请号：US16561816
申请日：2019-09-05
Applicant: OLYMPUS CORPORATION
Inventor： Keigo MATSUO , Hisashi ODE , Toshiro OKAMURA , Atsushi DOI , Satoshi WATANABE
Abstract: A lens system is configured to form an image of an object on an imaging surface of an image sensor. A branching optical system is configured such that an image-forming light flux in the lens system is split and propagated into a plurality of optical paths having different optical path lengths and such that the principal rays of a plurality of image-forming light fluxes obtained after the splitting are incident on a predetermined region of the image sensor.
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