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    A KIT FOR DETECTING MICRO-RNA EXTRACTED FROM A SAMLPLE OF BODY FLUID AS WELL AND A METHOD FOR THE DETECTION THEREOF
    1.
    发明申请
    A KIT FOR DETECTING MICRO-RNA EXTRACTED FROM A SAMLPLE OF BODY FLUID AS WELL AND A METHOD FOR THE DETECTION THEREOF 审中-公开
    用于检测从身体液体提取的微RNA的试剂盒及其检测方法

    公开(公告)号：WO2014191850A1

    公开(公告)日：2014-12-04

    申请号：PCT/IB2014/060793

    申请日：2014-04-17

    Applicant: OPTOELETTRONICA ITALIA S.R.L

    Inventor： MAGLIONE, Alfredo ,  RESS, Cristina

    IPC: G01N21/64

    CPC classification number: C12Q1/6876 ,  C12Q1/6825 ,  C12Q2600/178 ,  G01N21/63 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/77 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/0633

    Abstract: It's disclosed a kit for detecting a micro-RNA of interest in at least one sample (C) extracted from a body fluid, comprising: at least one device (2) including a housing casing (2a) in which at least one housing seat (2b) is obtained for said at least one sample (C), and at least one opening (2c) through which said housing seat (2b) is accessible from the outside; at least one container means (3) for said at least one sample (C), said at least one container means (3) being insertable/disconnectable in/from said housing seat (2b) through said at least one opening (2c); at least one optical excitation group (5), housed in said housing casing (2a), designed to emit at least one excitation light radiation (λ, λ1 ) towards said at least one housing seat (2b); at least one detection group (6), designed to detect at least one emission light radiation (λ2), that can be generated, in use, by said at least one sample (C), said at least one sample (C) being optically excitable by said at least one excitation light radiation (λ, λ1) emitted by said at least one optical excitation group (5), said at least one detection group (6) being designed to supply at least one electric output signal (SO- signal output) correlated with the quantity, in said at least one sample (C), of said micro-RNA of interest; at least one processing unit (7) designed to receive and process said at least one electric signal (SO) and to output an index correlated with the quantity of said micro-RNA of interest in said at least one sample (C); said at least one container means (3) being made of a material permeable to said at least one excitation light radiation (λ, λ1) and to said at least one emission light radiation (A2); said at least one group (6) for detecting said emission light radiation (A2) comprises at least one sensor means (6a) of silicon photomultiplier type.

    Abstract translation: 公开了用于检测从体液中提取的至少一个样品（C）中感兴趣的微RNA的试剂盒，其包括：至少一个装置（2），其包括壳体壳体（2a），其中至少一个壳体座 获得所述至少一个样品（C）的至少一个开口（2c），以及至少一个开口（2c），所述壳体座（2b）可以从外部进入; 用于所述至少一个样品（C）的至少一个容器装置（3），所述至少一个容器装置（3）可通过所述至少一个开口（2c）从所述壳体座（2b）插入/断开; 容纳在所述壳体壳体（2a）中的至少一个光学激发组（5）被设计成朝向所述至少一个壳体座（2b）发射至少一个激发光辐射（λ，λ1）; 至少一个检测组（6），被设计成检测在所述至少一个样品（C）中可以在使用中产生的至少一个发射光辐射（λ2），所述至少一个样品（C）是光学的 由所述至少一个光学激发组（5）发射的所述至少一个激发光辐射（λ，λ1）激发，所述至少一个检测组（6）被设计成提供至少一个电输出信号（SO-信号 输出）与所述至少一个样品（C）中所述感兴趣的微RNA的量相关; 至少一个处理单元（7）被设计为接收和处理所述至少一个电信号（SO）并输出与所述至少一个样品（C）中的所述感兴趣的微RNA的量相关的指数; 所述至少一个容器装置（3）由可透过所述至少一个激发光辐射（λ，λ1）和所述至少一个发射光辐射（A2）的材料制成; 所述至少一个用于检测所述发射光辐射的组（6）包括至少一个硅光电倍增器类型的传感器装置（6a）。

    RADIATION CONCENTRATING DEVICE
    2.
    发明申请
    RADIATION CONCENTRATING DEVICE 审中-公开
    辐射浓缩装置

    公开(公告)号：WO2007121971A1

    公开(公告)日：2007-11-01

    申请号：PCT/EP2007/003547

    申请日：2007-04-23

    Applicant: OPTOELETTRONICA ITALIA S.R.L. ,  MOLON, Sergio ,  MAGLIONE, Alfredo

    Inventor： MOLON, Sergio ,  MAGLIONE, Alfredo

    IPC: F24J2/06 ,  G02B7/182 ,  H01L31/0232 ,  G02B17/06

    CPC classification number: G02B19/0023 ,  F24S23/71 ,  F24S25/40 ,  F24S25/632 ,  F24S2023/872 ,  F24S2025/6007 ,  G02B7/183 ,  G02B19/0042 ,  Y02E10/42 ,  Y02E10/47

    Abstract: A radiation concentrating device, comprising a substantially parabolic mirror (11), which is adapted to reflect the energy radiation or electromagnetic radiation (12) that reaches it so as to converge toward an active area (13) of a receiving element (14) arranged in front, the active area being interposed between the focal point of the mirror (11) and the mirror (11) itself, the mirror (11) and the receiving element (14) being fixed by way of coupling means to a same base (15). The transverse dimension (A) of the active area (13) is smaller than the transverse dimension (B) of the mirror (11) arranged in front. The base (115) is preset to support a plurality of parabolic mirrors (111) and corresponding receiving elements (114), which are mutually connected by means of conductors (116).

    Abstract translation: 一种辐射聚集装置，包括基本上抛物面的反射镜（11），其适于反射到达其的能量辐射或电磁辐射（12），以朝向被布置的接收元件（14）的有源区域（13）会聚。 在前面，有源区被插入在反射镜（11）的焦点和反射镜（11）本身之间，反射镜（11）和接收元件（14）通过耦合装置固定到相同的基座（ 15）。 有源区域（13）的横向尺寸（A）小于布置在前面的反射镜（11）的横向尺寸（B）。 基座（115）被预设为支撑多个抛物面镜（111）和相应的接收元件（114），它们通过导体（116）相互连接。

    SYSTEM FOR MEASURING THE POSITION OF A MECHANICAL MEMBER AND METHOD FOR MEASURING THE POSITION OF A MECHANICAL MEMBER
    3.
    发明公开
    SYSTEM FOR MEASURING THE POSITION OF A MECHANICAL MEMBER AND METHOD FOR MEASURING THE POSITION OF A MECHANICAL MEMBER 审中-公开

    公开(公告)号：EP3379207A1

    公开(公告)日：2018-09-26

    申请号：EP18162678.9

    申请日：2018-03-19

    Applicant: Giuliani S.r.l. ,  Optoelettronica Italia S.R.L.

    Inventor： BATTISTI, Nicola ,  MAGLIONE, Alfredo

    IPC: G01D5/347 ,  G01D5/245

    Abstract: System for measuring the position of a mechanical member, which comprises optical detection means (2) intended to be arranged on a first mechanical member (101), and a positioning track (3) intended to be arranged on a second mechanical member (102) susceptible of relative motion with respect to the first mechanical member (101).
    The positioning track (3) is provided with at least one succession (4) of multiple sectors (5), and each of which comprises a first delimitation section (11) and a second delimitation section (12) spaced from each other, and a first identification section (13) and a second identification section (14) which are provided with a different optical contrast with respect to the first delimitation section (11) and to the second delimitation section (12).
    In each said sector (5), the first identification section (13) is delimited between the first delimitation section (11) and the second delimitation section (12).
    In addition, the length of the identification sections (13, 14) of each said sector (5) is different from the length of the identification sections (13, 14) of each other sector (5) of the succession (4), so as to unequivocally identify the corresponding sector (5).

    DEVICE AND METHOD FOR DETETING BIOMOLECULES
    4.
    发明公开
    DEVICE AND METHOD FOR DETETING BIOMOLECULES 审中-公开

    公开(公告)号：EP4279904A1

    公开(公告)日：2023-11-22

    申请号：EP23173727.1

    申请日：2023-05-16

    Applicant: Optoelettronica Italia S.R.L.

    Inventor： MAGLIONE, Alfredo ,  DETASSIS, Simone ,  RESS, Cristina ,  LUTTERI, Marco

    IPC: G01N21/64 ,  C12Q1/6818 ,  C12Q1/6825

    Abstract: Device for detecting biomolecules, comprising a container (2) intended to be filled with a mixture comprising a biomolecule (30) to be detected, a reagent (4) bondable to the biomolecule (30) and susceptible of emitting a first light radiation (λ 1 ) in fluorescence or chemiluminescence, and a plurality of magnetic beads (41) chemically bondable to the biomolecule (30). The device comprises a first detector (71) for detecting the first light radiation (λ 1 ) for detecting the biomolecule (30) concentration (C), a first emitter (61) for emitting a second light radiation (λ 2 ) for irradiating the magnetic beads (41), and a second detector (72) for detecting a third light radiation (λ 3 ) consequently transmitted, reflected or emitted by the magnetic beads (41) for detecting the quantity of magnetic beads (41). The device also comprises a logic control unit (8) configured for calculating a correct concentration (C) value of biomolecule (30) on the basis of the above measurements of the light radiations (λ 1 , λ 3 ).

    POSITION SENSOR FOR A MECHANICAL DEVICE AND METHOD FOR OPERATING SAID POSITION SENSOR
    5.
    发明公开
    POSITION SENSOR FOR A MECHANICAL DEVICE AND METHOD FOR OPERATING SAID POSITION SENSOR 审中-公开

    公开(公告)号：EP4063796A1

    公开(公告)日：2022-09-28

    申请号：EP22164222.6

    申请日：2022-03-24

    Applicant: Optoelettronica Italia S.R.L. ,  Giuliani S.r.l.

    Inventor： MAGLIONE, Alfredo ,  BATTISTI, Nicola

    IPC: G01D3/08 ,  G01D5/347

    Abstract: Position sensor for a mechanical device, comprising: at least one optical emitter (2), which is arranged for projecting an incident radiation (RI) on a positioning track (107) made on a movable member of the mechanical device and provided with multiple optical sections (108, 109) with different optical contrast; at least one optical detector (3), which is arranged for detecting a reflected radiation (RF) coming from the positioning track (107) and for generating a corresponding measurement signal (SM); an electronic processing unit (4), which is operatively connected to the optical detector (3) in order to receive the measurement signal (SM) and is arranged for calculating, on the basis of such measurement signal (SM), a reflectance value (VR) indicative of the reflectivity of the zone of the positioning track (107) hit by the incident ray (RI) so as to distinguish the different optical sections (108, 109) of the positioning track (107) itself.
    The position sensor also comprises a signaling module (9) operatively associated with the electronic processing unit (4) and arranged for sending a warning signal (SA) as a function of the reflectance value (VR), so as to provide to the user indications relative to the level of deterioration of the optical sections (108, 109) of the positioning track (107).

    CYLINDER-PISTON UNIT AND METHOD OF DETECTING CONTINUOSLY THE RECIPROCAL POSITION BETWEEN CYLINDER AND PISTON OF SUCH UNIT
    9.
    发明公开
    CYLINDER-PISTON UNIT AND METHOD OF DETECTING CONTINUOSLY THE RECIPROCAL POSITION BETWEEN CYLINDER AND PISTON OF SUCH UNIT 审中-公开
    缸体活塞单元和方法之间的气缸和活塞这样的一个单位相互位置连续检测

    公开(公告)号：EP3030794A1

    公开(公告)日：2016-06-15

    申请号：EP14771383.8

    申请日：2014-07-24

    Applicant: Optoelettronica Italia S.R.L. ,  Giuliani S.r.l.

    Inventor： MAGLIONE, Alfredo ,  BATTISTI, Nicola

    IPC: F15B15/28 ,  G01D5/347 ,  G01D5/246 ,  G01D5/36 ,  H03M1/24

    CPC classification number: F15B15/2846 ,  F15B15/2876 ,  G01D5/246 ,  G01D5/34746 ,  G01D5/34792 ,  H03M1/202 ,  H03M1/287

    Abstract: A cylinder-piston unit including: at least one cylinder including a tubular body (2); at least one piston (5) liable with a respective rod (5a), said piston (5) and said rod (5a) being translatable longitudinally in said tubular body (2) of said cylinder, at least one reference codification (C) extending for at least a section (dC) on the surface of said rod (5a), along the longitudinal axis of the same; at least detecting means (7), movable anchorable to said tubular body (2), faced, in use, towards said rod (5a) and suitable to detect said at least one reference codification (C) and to emit at the output at least a corresponding output electrical signal (s7), at least a reference zone (7c) of amplitude (d7c) delimited from said detecting means (7), said at least one reference codification (C) being detectable in correspondence to said at least one detection zone (7c); said at least one reference codification (C) including at least one plurality of adjacent sectors ( . . . , Si−1, Si, Si+1, . . . ) extending along said longitudinal axis of said rod (5a), each of them for a section (dSi) of equal length; each sector (Si) includes a plurality of optical contrast zones (si1, si2, si3), each of them extending along said longitudinal axis of said rod (5a) for a respective section of extension (dsi1, dsi2, dsi3) such as the sum of the extensions of said sections of extensions (dsi1+dsi2 . . . ), in each sector (Si) is lower or equal to said amplitude (d7c) of said detecting zone (7c); said optical contrast zones (si1, si2, si3) being arranged in each sector (Si) according to the same sequence; and wherein in each sector (Si) at least one optical contrast zone (si1, si2, si3) shows said at least one respective section of extension (ds1, ds2, ds3) of different length compared to the length of the same section of extension in the other sectors (Si−2, Si−1, Si+1, Si+2, . . . ), therefore each sector (Si) remains univocally definable from the length of said at least one section of extension (dsi1, dsi2, dsi3) of said optical contrast zones (si1, si2, si3) in it included.

    A KIT FOR DETECTING MICRO-RNA EXTRACTED FROM A SAMLPLE OF BODY FLUID AS WELL AND A METHOD FOR THE DETECTION THEREOF
    10.
    发明公开
    A KIT FOR DETECTING MICRO-RNA EXTRACTED FROM A SAMLPLE OF BODY FLUID AS WELL AND A METHOD FOR THE DETECTION THEREOF 审中-公开
    KIT为从体液样品检测装置提取微RNA及其检测方法

    公开(公告)号：EP3004846A1

    公开(公告)日：2016-04-13

    申请号：EP14723887.7

    申请日：2014-04-17

    Applicant: Optoelettronica Italia S.R.L.

    Inventor： MAGLIONE, Alfredo ,  RESS, Cristina

    IPC: G01N21/64

    CPC classification number: C12Q1/6876 ,  C12Q1/6825 ,  C12Q2600/178 ,  G01N21/63 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/77 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/0633

    Abstract: It's disclosed a kit for detecting a micro-RNA of interest in at least one sample (C) extracted from a body fluid, comprising: at least one device (2) including a housing casing (2a) in which at least one housing seat (2b) is obtained for said at least one sample (C), and at least one opening (2c) through which said housing seat (2b) is accessible from the outside; at least one container means (3) for said at least one sample (C), said at least one container means (3) being insertable/disconnectable in/from said housing seat (2b) through said at least one opening (2c); at least one optical excitation group (5), housed in said housing casing (2a), designed to emit at least one excitation light radiation (λ, λ1 ) towards said at least one housing seat (2b); at least one detection group (6), designed to detect at least one emission light radiation (λ2), that can be generated, in use, by said at least one sample (C), said at least one sample (C) being optically excitable by said at least one excitation light radiation (λ, λ1) emitted by said at least one optical excitation group (5), said at least one detection group (6) being designed to supply at least one electric output signal (SO- signal output) correlated with the quantity, in said at least one sample (C), of said micro-RNA of interest; at least one processing unit (7) designed to receive and process said at least one electric signal (SO) and to output an index correlated with the quantity of said micro-RNA of interest in said at least one sample (C); said at least one container means (3) being made of a material permeable to said at least one excitation light radiation (λ, λ1) and to said at least one emission light radiation (A2); said at least one group (6) for detecting said emission light radiation (A2) comprises at least one sensor means (6a) of silicon photomultiplier type.

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