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    PATTERNED POLYMERIC STRUCTURES, PARTICULARLY MICROSTRUCTURES, AND METHODS FOR MAKING SAME
    1.
    发明专利
    PATTERNED POLYMERIC STRUCTURES, PARTICULARLY MICROSTRUCTURES, AND METHODS FOR MAKING SAME 未知

    公开(公告)号：AU2002367868A1

    公开(公告)日：2003-10-27

    申请号：AU2002367868

    申请日：2002-08-01

    Applicant: OREGON STATE

    Inventor： YAN MINGDI ,  BARTLETT MICHELE

    IPC: B01J20/285 ,  B01J20/281 ,  B01J20/283 ,  C08K20060101 ,  C08K3/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N30/88 ,  H01L21/31

    Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

    METHOD OF MAKING AND USING FLUORESCENT-TAGGED NANOPARTICLES AND MICROARRAYS
    2.
    发明申请
    METHOD OF MAKING AND USING FLUORESCENT-TAGGED NANOPARTICLES AND MICROARRAYS 审中-公开
    制备和使用荧光标记纳米颗粒和微米阵列的方法

    公开(公告)号：WO2012071461A2

    公开(公告)日：2012-05-31

    申请号：PCT/US2011061936

    申请日：2011-11-22

    Applicant: OREGON STATE ,  YAN MINGDI ,  WANG XIN ,  JAYAWARDENA H S N

    Inventor： YAN MINGDI ,  WANG XIN ,  JAYAWARDENA H S N

    IPC: G01N33/533 ,  A61K47/48 ,  C12Q1/68 ,  G01N33/551 ,  G01N33/68

    CPC classification number: G01N33/587 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0065 ,  A61K49/0093 ,  G01N2400/00 ,  Y10T436/143333

    Abstract: Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern using statistical analysis to produce score plots illustrating the level of differentiation and/or classification. Also disclosed are methods for making perhalophenylazide-derived nanoparticle probes, individually or by using a microarray technique. Particular embodiments concern methods for using the perhalophenylazide-derived nanoparticle probes to diagnose, detect, and/or treat a disease. Kits comprising the perhalophenylazide-derived nanoparticle probes are also disclosed.

    Abstract translation: 所公开的实施方案涉及使用全卤代苯酰叠氮衍生的纳米粒子探针或多种这样的探针来区分和分类一个或多个靶标。 具体实施方式涉及使用统计分析来产生说明分化和/或分类水平的分数图。 还公开了单独地或通过使用微阵列技术来制备来自perhalophenylazide的纳米粒子探针的方法。 具体实施方式涉及使用来自过氯化苯酰基化物的纳米粒子探针来诊断，检测和/或治疗疾病的方法。 还公开了包含来自perhalophenylazide的纳米粒子探针的试剂盒。

    7.
    发明专利
    未知

    公开(公告)号：AT541237T

    公开(公告)日：2012-01-15

    申请号：AT02806828

    申请日：2002-08-01

    Applicant: OREGON STATE

    Inventor： YAN MINGDI ,  BARTLETT MICHELE

    IPC: B01J20/285 ,  G03F7/00 ,  B01J20/281 ,  B01J20/283 ,  C08K20060101 ,  C08K3/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N30/88 ,  G03F7/008 ,  G03F7/012 ,  G03F7/11 ,  H01L21/31

    Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

    Chemical functionalization of surfaces
    8.
    发明专利
    Chemical functionalization of surfaces 未知

    公开(公告)号：AU6231794A

    公开(公告)日：1994-08-15

    申请号：AU6231794

    申请日：1994-01-21

    Applicant: OREGON STATE

    Inventor： KEANA JOHN F W ,  WYBOURNE MARTIN N ,  CAI SUI XIONG ,  YAN MINGDI

    IPC: C08J7/12 ,  B01J19/08 ,  C01B31/04 ,  C08F8/34 ,  C23C16/02 ,  G01N21/45 ,  G01N21/77 ,  G01N33/543 ,  G03F7/20 ,  H01L21/368 ,  G03C5/00

    Abstract: Methods for covalently modifying surfaces of various substrates are disclosed, along with various substrates having surfaces modified by such methods. Candidate surfaces include various polymeric, siliceous, metallic, allotrophic forms of carbon, and semiconductor surfaces. The surfaces are exposed to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The nitrene covalently reacts with any of various chemical groups present on the substrate surface, thereby effecting nitrene addition of the functionalizing groups to the substrate surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface, thereby dramatically altering the chemical behavior of the surface. Such functionalizations of the surface can be done in a single reactive step or in multiple reactive steps.

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