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公开(公告)号：CA2687062A1
公开(公告)日：2008-11-20
申请号：CA2687062
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , ZHAO PEGIAN , LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS
Abstract: Mitigative and remedial approaches to reduction of autofluorescence backg round noise are applied in analytical systems that rely upon sensitive measu rement of fluorescent signals from arrays of fluorescent signal sources. Suc h systems are for particular use in fluorescence based sequencing by incorpo ration systems that rely upon small numbers or individual fluorescent molecu les in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using hi ghly multiplexed, high-density optical systems to illuminate high- density s ample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are app lied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and d erivation of sequence information from such synthesis.
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公开(公告)号：AU2008251861A1
公开(公告)日：2008-11-20
申请号：AU2008251861
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , ZHAO PEGIAN , ZHONG CHENG-FRANK , LUNDQUIST PAUL , ZACCARIN DENIS
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3.发明申请
公开(公告)号：WO2009038668A3
公开(公告)日：2009-05-22
申请号：PCT/US2008010652
申请日：2008-09-12
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , LUNDQUIST PAUL , ZHONG CHENG FRANK , ZHAO PEGIAN , TURNER STEPHEN
Inventor： LUNDQUIST PAUL , ZHONG CHENG FRANK , ZHAO PEGIAN , TURNER STEPHEN
IPC: G01N21/64
CPC classification number: G01N27/44721
Abstract: Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.
Abstract translation: 用于使用高度多路复用的高密度光学系统来分析高度多路复用的样本阵列以照射高密度样本阵列和/或提供从这样的高密度阵列发出的检测并且优选地共焦检测关闭信号的系统和方法。 系统和方法应用于各种不同的分析操作，包括生物和生物化学反应的分析，包括核酸合成和从这种合成得到的序列信息。
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4.发明公开METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE 审中-公开方法和系统的分析荧光材料与荧光减少OWN
公开(公告)号：EP2150806A4
公开(公告)日：2013-01-02
申请号：EP08767652
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS , ZHAO PEGIAN , TURNER STEPHEN
CPC classification number: G01N27/447 , G01N21/6452 , G01N21/6458 , G02B21/0032
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