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    Methods and systems for analyzing fluorescent materials with reduced autofluorescence
    1.
    发明专利
    Methods and systems for analyzing fluorescent materials with reduced autofluorescence 未知

    公开(公告)号：AU2008251861B2

    公开(公告)日：2014-03-20

    申请号：AU2008251861

    申请日：2008-05-09

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： ZHONG CHENG-FRANK ,  ZHAO PEIQIAN ,  LUNDQUIST PAUL ,  TURNER STEPHEN ,  ZACCARIN DENIS

    IPC: G01N21/76 ,  G01N24/00

    Abstract: Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.

    METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE
    3.
    发明专利
    METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE 未知

    公开(公告)号：CA2687062C

    公开(公告)日：2016-04-12

    申请号：CA2687062

    申请日：2008-05-09

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： LUNDQUIST PAUL ,  ZHONG CHENG-FRANK ,  ZACCARIN DENIS ,  ZHAO PEIQIAN ,  TURNER STEPHEN

    IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/68 ,  C40B60/00 ,  G01N33/52

    Abstract: Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.

    METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITHREDUCED AUTOFLUORESCENCE
    4.
    发明专利
    METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITHREDUCED AUTOFLUORESCENCE 未知

    公开(公告)号：CA2687062A1

    公开(公告)日：2008-11-20

    申请号：CA2687062

    申请日：2008-05-09

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： TURNER STEPHEN ,  ZHAO PEGIAN ,  LUNDQUIST PAUL ,  ZHONG CHENG-FRANK ,  ZACCARIN DENIS

    IPC: G01N21/76 ,  G01N24/00

    Abstract: Mitigative and remedial approaches to reduction of autofluorescence backg round noise are applied in analytical systems that rely upon sensitive measu rement of fluorescent signals from arrays of fluorescent signal sources. Suc h systems are for particular use in fluorescence based sequencing by incorpo ration systems that rely upon small numbers or individual fluorescent molecu les in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using hi ghly multiplexed, high-density optical systems to illuminate high- density s ample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are app lied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and d erivation of sequence information from such synthesis.

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