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    HIGHLY MULTIPLEXED CONFOCAL DETECTION SYSTEMS AND METHODS OF USING SAME
    3.
    发明申请
    HIGHLY MULTIPLEXED CONFOCAL DETECTION SYSTEMS AND METHODS OF USING SAME 审中-公开
    高度多元化的协同检测系统及其使用方法

    公开(公告)号：WO2009038668A3

    公开(公告)日：2009-05-22

    申请号：PCT/US2008010652

    申请日：2008-09-12

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  LUNDQUIST PAUL ,  ZHONG CHENG FRANK ,  ZHAO PEGIAN ,  TURNER STEPHEN

    Inventor： LUNDQUIST PAUL ,  ZHONG CHENG FRANK ,  ZHAO PEGIAN ,  TURNER STEPHEN

    IPC: G01N21/64

    CPC classification number: G01N27/44721

    Abstract: Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.

    Abstract translation: 用于使用高度多路复用的高密度光学系统来分析高度多路复用的样本阵列以照射高密度样本阵列和/或提供从这样的高密度阵列发出的检测并且优选地共焦检测关闭信号的系统和方法。 系统和方法应用于各种不同的分析操作，包括生物和生物化学反应的分析，包括核酸合成和从这种合成得到的序列信息。

    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS
    5.
    发明申请
    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS 审中-公开
    用于分析材料的基板，系统和方法

    公开(公告)号：WO2008028160A3

    公开(公告)日：2008-11-06

    申请号：PCT/US2007077454

    申请日：2007-08-31

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  LUNDQUIST PAUL ,  TURNER STEPHEN

    Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

    IPC: F21V9/16

    CPC classification number: G01N21/648 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N2021/7786 ,  G02B6/43

    Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

    Abstract translation: 用于分析材料的衬底，系统和方法，其包括设置在衬底上或衬底内的波导阵列，使得从波导发出的消逝场照射设置在衬底表面上或其附近的材料，从而允许分析这些材料。 底物，系统和方法用于各种分析操作，包括核酸分析，包括杂交和测序分析，细胞分析和其他分子分析。

    INTEGRATED TARGET WAVEGUIDE DEVICES AND SYSTEMS FOR OPTICAL COUPLING
    6.
    发明专利
    INTEGRATED TARGET WAVEGUIDE DEVICES AND SYSTEMS FOR OPTICAL COUPLING 未知

    公开(公告)号：CA2989344A1

    公开(公告)日：2016-12-15

    申请号：CA2989344

    申请日：2016-06-11

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： WANG SHANG ,  FOQUET MATHIEU ,  LUNDQUIST PAUL ,  RULISON AARON ,  MCDONALD MARK ,  HERRMANN ARIEL

    IPC: G02B6/26 ,  G02B6/34

    Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.

    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS
    9.
    发明专利
    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS 未知

    公开(公告)号：CA2662521A1

    公开(公告)日：2008-03-06

    申请号：CA2662521

    申请日：2007-08-31

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

    IPC: F21V9/16

    Abstract: Substrates, systems and methods for analyzing materials that include wave guide arrays disposed upon or within the substrate such that evanescent fiel ds emanating from the waveguides illuminate materials disposed upon or proxi mal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical oper ations, including, inter alia, nucleic acid analysis, including hybridizatio n and sequencing analyses, cellular analyses and other molecular analyses.

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