公开(公告)号：KR880000431B1

公开(公告)日：1988-03-24

申请号：KR850000775

申请日：1985-02-07

Applicant: PFIZER

Inventor： CARDINAL JOHN R

IPC: A23L3/00 ,  A01N25/34 ,  A61K9/00 ,  A61K9/22 ,  A61K9/50 ,  A61K9/70 ,  A61K31/425 ,  A61K31/505 ,  A61K31/565 ,  A61M31/00 ,  A61P33/10 ,  B01J4/04 ,  A61K9/20

公开(公告)号：HUT41257A

公开(公告)日：1987-04-28

申请号：HU47385

申请日：1985-02-07

Applicant: PFIZER

Inventor： CARDINAL JOHN R

IPC: A23L3/00 ,  A01N25/34 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/50 ,  A61K9/70 ,  A61K31/425 ,  A61K31/505 ,  A61K31/565 ,  A61M31/00 ,  A61P33/10 ,  B01J4/04 ,  B32B33/00

Abstract: Laminate device for the controlled and prolonged release of at least one active agent to an ambient environment comprising at least one core sheet, said core sheet or sheets comprising said agent or agents in a polymer matrix, and, in a preferred embodiment, a porosity enhancing agent in admixture with said agent; said core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agenit or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. In a modification of said device the perimeter edge thereof is coated by an inert polymeric film substantially impermeable to said environment and to said agent or agents. Also included are methods for making such a device.

公开(公告)号：DD231984A5

公开(公告)日：1986-01-15

申请号：DD27312385

申请日：1985-02-07

Applicant: PFIZER

Inventor： CARDINAL JOHN R

IPC: A23L3/00 ,  A01N25/34 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/50 ,  A61K9/70 ,  A61K31/425 ,  A61K31/505 ,  A61K31/565 ,  A61M31/00 ,  A61P33/10 ,  B01J4/04 ,  B32B33/00 ,  A61K9/32 ,  A61K9/58 ,  A61K47/00

Abstract: Laminate device for the controlled and prolonged release of at least one active agent to an ambient environment comprising at least one core sheet, said core sheet or sheets comprising said agent or agents in a polymer matrix, and, in a preferred embodiment, a porosity enhancing agent in admixture with said agent; said core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agenit or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. In a modification of said device the perimeter edge thereof is coated by an inert polymeric film substantially impermeable to said environment and to said agent or agents. Also included are methods for making such a device.

公开(公告)号：PT91560B

公开(公告)日：1995-05-04

申请号：PT9156089

申请日：1989-08-28

Applicant: PFIZER

Inventor： KORSMEYER RICHARD WILKER ,  CARDINAL JOHN R ,  HERBIG SCOTT MAX ,  THOMBRE AVINASH GOVIND ,  LO JEELIN ,  SMITH KELLY LINCOLN

IPC: A61J3/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K9/62 ,  A61K45/08

Abstract: A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.

公开(公告)号：LV5396A3

公开(公告)日：1994-03-10

申请号：LV931166

申请日：1993-10-22

Applicant: PFIZER

Inventor： CARDINAL JOHN R

IPC: A61K9/50

公开(公告)号：PL163079B1

公开(公告)日：1994-02-28

申请号：PL28122089

申请日：1989-08-30

Applicant: PFIZER

Inventor： CARDINAL JOHN R ,  HERBIG SCOTT M ,  KORSMEYER RICHARD W ,  LO JEELIN ,  SMITH KELLY L ,  THOMBRE AVINASH G

IPC: A61J3/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K9/62 ,  A61K45/08

Abstract: A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.

公开(公告)号：EG19189A

公开(公告)日：1994-11-30

申请号：EG42189

申请日：1989-08-29

Applicant: PFIZER

Inventor： CARDINAL JOHN R

IPC: A61J3/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K9/62 ,  A61K45/08

Abstract: A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.

公开(公告)号：DD289466A5

公开(公告)日：1991-05-02

申请号：DD33216689

申请日：1989-08-29

Applicant: PFIZER

Inventor： CARDINAL JOHN R ,  HERBIG SCOTT M ,  KORSMEYER RICHARD W ,  LO JEELIN ,  SMITH KELLY L ,  THOMBRE AVINASH G

IPC: A61J3/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K9/62 ,  A61K45/08

Abstract: A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.

公开(公告)号：CA1237982A

公开(公告)日：1988-06-14

申请号：CA473649

申请日：1985-02-06

Applicant: PFIZER

Inventor： CARDINAL JOHN R

IPC: A23L3/00 ,  A01N25/34 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/50 ,  A61K9/70 ,  A61K31/425 ,  A61K31/505 ,  A61K31/565 ,  A61M31/00 ,  A61P33/10 ,  B01J4/04 ,  B32B33/00

Abstract: LAMINATE DEVICE FOR CONTROLLED AND PROLONGED RELEASE OF SUBSTANCES TO AN AMBIENT ENVIRONMENT Laminate device for the controlled and prolonged release of at least one active agent to an ambient environment comprising at least one core sheet, said core sheet or sheets comprising said agent or agents in a polymer matrix, and, in a preferred embodiment, a porosity enhancing agent in admixture with said agent; said core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. In a modification of said device the perimeter edge thereof is coated by an inert polymeric film substantially impermeable to said environment and to said agent or agents. Also included are methods for making such a device.