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公开(公告)号：JP2013253089A
公开(公告)日：2013-12-19
申请号：JP2013160858
申请日：2013-08-01
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide an irreversible Bruton's kinase inhibitor compound to be used in treatment of diseases.SOLUTION: There is provided a compound illustrated in formulae.
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公开(公告)号：WO2008121742A3
公开(公告)日：2008-11-27
申请号：PCT/US2008058528
申请日：2008-03-27
Applicant: PHARMACYCLICS INC , HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
CPC classification number: C07D487/04 , A61K31/52 , C07D471/04 , C12Q1/485 , G01N33/57426 , G01N2440/14 , G01N2500/00
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
Abstract translation: 本文描述的是不可逆激酶抑制剂化合物，用于合成这种不可逆抑制剂的方法，以及使用这种不可逆抑制剂治疗疾病的方法。 本文进一步描述了用于确定包括激酶在内的蛋白质的合适的不可逆抑制剂的方法，测定和系统。
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3.发明申请
公开(公告)号：WO2009052323A3
公开(公告)日：2009-09-11
申请号：PCT/US2008080221
申请日：2008-10-16
Applicant: PHARMACYCLICS INC , LOURY DAVID , PURRO NORBERT
Inventor： LOURY DAVID , PURRO NORBERT
CPC classification number: A61K31/4184 , A61K31/4164 , A61K41/00 , A61K45/06 , C07D209/00 , C07D235/12 , C07D235/18 , A61K2300/00
Abstract: Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I.
Abstract translation: 本文使用式I化合物公开了使用因子VIIa抑制剂治疗癌症和血栓栓塞障碍。
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4.发明申请INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS 审中-公开用于治疗固体肿瘤的BRUTON的酪氨酸激酶的抑制剂
公开(公告)号：WO2010009342A3
公开(公告)日：2010-05-14
申请号：PCT/US2009050897
申请日：2009-07-16
Applicant: PHARMACYCLICS INC , HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
CPC classification number: A61K31/519 , A61K31/00 , A61K31/337 , A61K31/52 , A61K31/675 , A61K31/704 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61K31/19
Abstract: Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
Abstract translation: 本文描述的是不可逆的Btk抑制剂化合物，以及使用这种不可逆抑制剂治疗以固体肿瘤的存在或发展为特征的疾病和病症的方法。
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5.发明公开MANUFACTURE, COMPOSITIONS AND USES OF COAGULATIONFACTOR VIIA MODULATOR 有权制造，组合物和COAGULATIONSFAKTORS VIIA调节剂的应用
公开(公告)号：EP2209801A4
公开(公告)日：2011-04-06
申请号：EP08839610
申请日：2008-10-16
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , PURRO NORBERT
CPC classification number: A61K31/4184 , A61K31/4164 , A61K41/00 , A61K45/06 , C07D209/00 , C07D235/12 , C07D235/18 , A61K2300/00
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Patent Agency Ranking6.发明公开INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS 有权BRUTON TYROSINE KINASE HEMMER治疗实体肿瘤
公开(公告)号：EP2307025A4
公开(公告)日：2011-11-30
申请号：EP09798770
申请日：2009-07-16
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/00 , A61K31/519 , A61P35/00
CPC classification number: A61K31/519 , A61K31/00 , A61K31/337 , A61K31/52 , A61K31/675 , A61K31/704 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61K31/19
Abstract: Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
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公开(公告)号：EP2139487A4
公开(公告)日：2010-04-21
申请号：EP08744513
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
CPC classification number: C07D487/04 , A61K31/52 , C07D471/04 , C12Q1/485 , G01N33/57426 , G01N2440/14 , G01N2500/00
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公开(公告)号：EA017865B1
公开(公告)日：2013-03-29
申请号：EA200901313
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
Abstract: Впатентеописанынеобратимыеингибиторыкиназ, способысинтезатакихнеобратимыхингибиторови способыприменениятакихнеобратимыхингибиторовдлялеченияболезней. Описанытакжеметодыанализаи системыдляопределениясоответствующегонеобратимогоингибиторабелка, включаякиназу.
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公开(公告)号：AU2013245503A1
公开(公告)日：2013-11-07
申请号：AU2013245503
申请日：2013-10-17
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , VERNER ERIK , CHEN WEI , HONIGBERG LEE , BUGGY JOSEPH
Abstract: Inhibitors of Bruton's Tyrosine Kinase for the Treatment of Solid Tumors Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
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公开(公告)号：CA2874756A1
公开(公告)日：2008-10-09
申请号：CA2874756
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: C07D487/04 , A61K31/519 , A61P19/02 , A61P29/00 , A61P37/06 , C12N9/12 , C12Q1/48 , G01N33/53
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
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