公开(公告)号：WO2011046964A3

公开(公告)日：2011-08-25

申请号：PCT/US2010052377

申请日：2010-10-12

Applicant: PHARMACYCLICS INC ,  CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

Abstract translation: 本文描述的是激酶抑制剂化合物，用于合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。 本文进一步描述了用于测定包括激酶在内的蛋白质的适当抑制剂的方法，测定和系统。

公开(公告)号：ES2590905T3

公开(公告)日：2016-11-24

申请号：ES13166272

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10

Abstract: Un compuesto que tiene la estructura:**Fórmula** o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：AU2010306921B2

公开(公告)日：2015-08-13

申请号：AU2010306921

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D401/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/14 ,  C07D487/04

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：ZA201202552B

公开(公告)日：2013-11-27

申请号：ZA201202552

申请日：2012-04-10

Applicant: PHARMACYCLICS INC

Inventor： LUO WENCHEN ,  SMYTH MARK STEPHEN ,  MODY TARAK D ,  LOURY DAVID J ,  VERNER ERIK ,  CHEN WEI

公开(公告)号：EP2393816A4

公开(公告)日：2011-12-14

申请号：EP10823966

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D487/04 ,  C07D519/00

公开(公告)号：EA021715B1

公开(公告)日：2015-08-31

申请号：EA201270553

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

Abstract: Изобретениепредусматриваетингибиторыкиназ, способысинтезатакихингибиторови способыприменениятакихингибиторовдлялеченияболезней. Крометого, предусмотренытакжеспособы, анализыи системыопределениясоответствующегоингибиторав белке, включаякиназу.

公开(公告)号：CL2012000917A1

公开(公告)日：2012-07-13

申请号：CL2012000917

申请日：2012-04-11

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  A61P35/00 ,  C07D487/04

Abstract: Compuestos derivados de pirazolo[3,4-D]pirimidina y sus sales, inhibidores de la tirosina quinasa de Bruton; composición farmacéutica que los comprende, útil para tratar una enfermedad o condición autoinmune tal como artritis reumatoide o lupus, para el tratamiento del cáncer, mastocitosis osteoporosis, entre otras enfermedades.

公开(公告)号：IN3012DEN2012A

公开(公告)日：2015-07-31

申请号：IN3012DEN2012

申请日：2012-04-09

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: A61K20060101

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：NZ599396A

公开(公告)日：2014-03-28

申请号：NZ59939610

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  MODY TARAK D ,  LOURY DAVID J ,  VERNER ERIK ,  LUO WENCHEN ,  SMYTH MARK STEPHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

Abstract: NZ 599396 The disclosure relates to pyrazolo-pyrimidine derivatives of formula (II) that are inhibitors of bruton’s tyrosine kinase (Btk), wherein the variables are as defined in the specification. The disclosure also relates to methods for synthesizing such inhibitors, and methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase. These compounds are suitable for treating an autoimmune disease or condition, a heteroimmune disease or condition, cancers including B-cell proliferative disorder is diffuse large B cell lymphoma, follicular lymphoma or chronic lymphocytic leukemia, mastocytosis, osteoporosis, and an inflammatory disease or condition.

公开(公告)号：SG10201506776RA

公开(公告)日：2015-10-29

申请号：SG10201506776R

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN