公开(公告)号：DE602004014193D1

公开(公告)日：2008-07-10

申请号：DE602004014193

申请日：2004-12-22

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： BLEUKX MARC MARIA ALEX ,  VON BUSCH HEINRICH ,  SCHWAN STEFAN ,  SCHIENE WOLFGANG

IPC: H05B41/282 ,  H05B41/28

公开(公告)号：DE602005011782D1

公开(公告)日：2009-01-29

申请号：DE602005011782

申请日：2005-04-19

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： JUESTEL THOMAS ,  HUPPERTZ PETRA ,  WIECHERT DETLEF UWE ,  MAYR WALTER ,  VON BUSCH HEINRICH

IPC: H01J1/00 ,  C09K11/77 ,  H01J20060101 ,  H01J61/44 ,  H01J65/04

公开(公告)号：WO2008056322A3

公开(公告)日：2008-11-13

申请号：PCT/IB2007054495

申请日：2007-11-06

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  VON BUSCH HEINRICH ,  SCHWEIZER BERND ,  GEORGI JENS C

Inventor： VON BUSCH HEINRICH ,  SCHWEIZER BERND ,  GEORGI JENS C

IPC: G06F19/00

CPC classification number: G06F19/3481

Abstract: An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.

Abstract translation: 提供了用于诸如放射疗法和化疗等不同疗法形式的癌症的疾病的个体患者疗法规划的设备，方法，系统，计算机可读介质和用途。 本发明的一个新方面是患者的骨髓抑制程度与每次治疗前测量的未成熟血小板计数有关。 本发明的一些实施例提供了允许降低预测骨髓抑制风险的不确定性水平的优点，并且因此能够通过增加对个体患者的辐射剂量和/或化学剂量来安全地改善治疗效果 而骨髓抑制的风险最小化。

公开(公告)号：WO2009031073A2

公开(公告)日：2009-03-12

申请号：PCT/IB2008053429

申请日：2008-08-26

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  VON BUSCH HEINRICH ,  GEORGI JENS-CHRISTOPH ,  SCHWEIZER BERND

Inventor： VON BUSCH HEINRICH ,  GEORGI JENS-CHRISTOPH ,  SCHWEIZER BERND

IPC: G06F19/00

CPC classification number: G06F19/3437 ,  G06F19/3456 ,  G06F19/3481 ,  G16H50/50

Abstract: A treatment planning apparatus (100) includes a treatment modeler (102). The treatment (104) modeler uses models (1121-N) of a plurality of treatment modalities in a treatment space (104) to generate a treatment protocol (110) that includes one or more the modalities in the treatment space. In one implementation, a treatment modality includes the removal of targeted treatment agents from an object.

Abstract translation: 治疗计划装置（100）包括治疗建模器（102）。 治疗（104）建模者使用治疗空间（104）中的多种治疗方式的模型（1121-N）来产生包括治疗空间中的一种或多种模态的治疗方案（110）。 在一个实施方案中，治疗方式包括从对象中去除靶向治疗剂。

公开(公告)号：WO2008059426A2

公开(公告)日：2008-05-22

申请号：PCT/IB2007054578

申请日：2007-11-12

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  GEORGI JENS-CHRISTOPH ,  SCHWEIZER BERND ,  VON BUSCH HEINRICH

Inventor： GEORGI JENS-CHRISTOPH ,  SCHWEIZER BERND ,  VON BUSCH HEINRICH

CPC classification number: G01T1/161 ,  A61B6/4258

Abstract: This invention relates to a system for determining a biodistribution of radioactive agents in a subject. According to the invention, a detector system comprising two or more detectors arranged to be attached to the subject at localized areas is used for detecting the radiation emitted from the imaging agents at localized tissues within the subject. The measuring results in separate radiation data sets associated to the tissues. The detectors are further being arranged to adapt the measuring rate to the pharmacokinetic behavior of the tissues in order to capture all relevant data points. A processor then uses the data sets for determining the radioactivity within each respective tissue and based thereon the biodistribution within the subject.

Abstract translation: 本发明涉及用于确定受试者中放射性试剂生物分布的系统。 根据本发明，包括两个或更多个检测器的检测器系统被布置成在局部区域处附接到受试者，用于检测在受试者内的局部组织处从成像剂发射的辐射。 测量结果与组织相关联的单独辐射数据集。 检测器还被布置成使测量速率适应组织的药代动力学行为，以捕获所有相关的数据点。 然后，处理器使用数据集来确定每个相应组织内的放射性，并且基于该对象内的生物分布。