公开(公告)号：CA2810004A1

公开(公告)日：2012-03-08

申请号：CA2810004

申请日：2011-08-31

Applicant: PORTOLA PHARM INC

Inventor： CAPODANNO VINCENT R ,  CORCORAN LIAM ,  MCNEVIN MICHAEL ,  ARROYO ITZIA ZORAIDA ,  WENSLOW ROBERT M ,  BALL RICHARD G ,  MARGELEFSKY ERIC L ,  MAHER TIMOTHY K ,  PANDEY ANJALI

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/02

Abstract: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.

公开(公告)号：NZ608442A

公开(公告)日：2015-04-24

申请号：NZ60844211

申请日：2011-08-31

Applicant: PORTOLA PHARM INC

Inventor： CAPODANNO VINCENT R ,  CORCORAN LIAM ,  MCNEVIN MICHAEL ,  ARROYO ITZIA ZORAIDA ,  WENSLOW ROBERT M ,  BALL RICHARD G ,  MARGELEFSKY ERIC L ,  MAHER TIMOTHY K ,  PANDEY ANJALI

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/02

Abstract: Two crystalline forms, Form II and Form III, of a maleate salt of betrixaban are described. Form II is an anhydrate and Form III is a hemihydrate. Betrixaban maleate is an inhibitor of the serine protease Factor Xa. The crystalline forms are useful for the treatment of thrombosis or thrombotic diseases.

公开(公告)号：AU2011295909B2

公开(公告)日：2015-05-21

申请号：AU2011295909

申请日：2011-08-31

Applicant: PORTOLA PHARM INC

Inventor： CAPODANNO VINCENT R ,  CORCORAN LIAM ,  MCNEVIN MICHAEL ,  ARROYO ITZIA ZORAIDA ,  WENSLOW ROBERT M ,  BALL RICHARD G ,  MARGELEFSKY ERIC L ,  MAHER TIMOTHY K ,  PANDEY ANJALI

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/02

Abstract: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.

公开(公告)号：AU2011295909A1

公开(公告)日：2013-04-04

申请号：AU2011295909

申请日：2011-08-31

Applicant: PORTOLA PHARM INC

Inventor： CAPODANNO VINCENT R ,  CORCORAN LIAM ,  MCNEVIN MICHAEL ,  ARROYO ITZIA ZORAIDA ,  WENSLOW ROBERT M ,  BALL RICHARD G ,  MARGELEFSKY ERIC L ,  MAHER TIMOTHY K ,  PANDEY ANJALI

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/02

Abstract: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.

公开(公告)号：CA2810004C

公开(公告)日：2019-09-10

申请号：CA2810004

申请日：2011-08-31

Applicant: PORTOLA PHARM INC

Inventor： CAPODANNO VINCENT R ,  CORCORAN LIAM ,  MCNEVIN MICHAEL ,  ARROYO ITZIA ZORAIDA ,  WENSLOW ROBERT M ,  BALL RICHARD G ,  MARGELEFSKY ERIC L ,  MAHER TIMOTHY K ,  PANDEY ANJALI

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/02

Abstract: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.