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    2.
    发明专利
    未知

    公开(公告)号：AT489375T

    公开(公告)日：2010-12-15

    申请号：AT06732696

    申请日：2006-03-24

    Applicant: POSTECH FOUNDATION ,  POSTECH ACAD IND FOUND

    Inventor： KIM KIMOON ,  KO YOUNG-HO ,  PARK KYENG-MIN ,  SELVAPALAM NARAYANAN ,  NAGARAJAN ERUMAIPATTY

    IPC: C07D305/14 ,  C07D487/04

    Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

    5.
    发明专利
    未知

    公开(公告)号：AT507229T

    公开(公告)日：2011-05-15

    申请号：AT02751843

    申请日：2002-07-03

    Applicant: POSTECH FOUNDATION

    Inventor： KIM KIMOON ,  ZHAO JIANZHANG ,  KIM HEE-JOON ,  KIM SOO-YOUNG ,  OH JINHO

    IPC: C07D487/22 ,  G01N27/333 ,  B01D9/02 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  C02F1/00 ,  C02F1/28 ,  C02F1/58 ,  C02F1/62 ,  C07D487/08 ,  G01N30/88

    Abstract: Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses: where X is O, S or NH; R 1 and R 2 are each independently selected from the group consisting of hydrogen, alkyl groups of 1 to 30 carbon atoms, alkenyl groups of 1 to 30 carbon atoms, alkynyl groups of 1 to 30 carbon atoms, alkylthio groups of 1 to 30 carbon atoms, alkylcarboxyl groups of 1 to 30 carbon atoms, hydroxyalkyl groups of 1 to 30 carbon atoms, alkylsilyl groups of 1 to 30 carbon atoms, alkoxy groups of 1 to 30 carbon atoms, haloalkyl groups of 1 to 30 carbon atoms, nitro group, alkylamine groups of 1 to 30 carbon atoms, amine group, aminoalkyl groups of 1 to 30 carbon atoms, unsubstituted cycloalkyl groups of 5 to 30 carbon atoms, cycloalkyl groups of 4 to 30 carbon atoms with hetero atoms, unsubstituted aryl groups of 6 to 30 carbon atoms, and aryl groups of 6 to 30 carbon atoms with hetero atoms; and n and m are independently integers from 4 to 20 and from 1 to 7, respectively. The cucurbituril derivative has enhanced solubility in common solvents, thereby providing wider applications.

    7.
    发明专利
    未知

    公开(公告)号：AT532790T

    公开(公告)日：2011-11-15

    申请号：AT02765666

    申请日：2002-09-18

    Applicant: POSTECH FOUNDATION

    Inventor： KIM KIMOON ,  JEON YOUNG JIN ,  KIM SOO-YOUNG ,  KO YOUNG HO

    IPC: C07D487/04 ,  C07F5/00 ,  C07F1/12 ,  C07F15/00

    Abstract: The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical composition having an anticancer effect can be obtained by using the inclusion compound according to the present invention. The pharmaceutical composition can prevent effective components from being biologically degraded in vivo and can exhibit continuous drug effect for a long time just by a single dosage by controlling the release time of the platinum complex once it reaches target tumor cells.

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