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    2.
    发明专利
    未知

    公开(公告)号：AT489375T

    公开(公告)日：2010-12-15

    申请号：AT06732696

    申请日：2006-03-24

    Applicant: POSTECH FOUNDATION ,  POSTECH ACAD IND FOUND

    Inventor： KIM KIMOON ,  KO YOUNG-HO ,  PARK KYENG-MIN ,  SELVAPALAM NARAYANAN ,  NAGARAJAN ERUMAIPATTY

    IPC: C07D305/14 ,  C07D487/04

    Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

    GEL COMPRISING CUCURBITRIL
    7.
    发明公开
    GEL COMPRISING CUCURBITRIL 无效
    凝胶含有CUCRBITRIL

    公开(公告)号：KR20070073225A

    公开(公告)日：2007-07-10

    申请号：KR20060000892

    申请日：2006-01-04

    Applicant: POSTECH FOUNDATION ,  POSTECH ACAD IND FOUND

    Inventor： KIM KI MOON ,  HWANG IL HA ,  JEON WOO SUNG ,  KIM HEE JOON ,  KIM DONG WOO ,  SELVAPALAM NARAYANAN ,  NAGARAJAN ERUMAIPATTY R

    IPC: C07D487/04

    CPC classification number: A61K9/06 ,  A61K31/573 ,  A61K38/00 ,  A61K41/0042 ,  A61K47/16

    Abstract: Provided is a gel comprising cucurbituril which is prepared by various methods, and is able to include various compounds and prepare a gel including medicines and a gel capable of being converted into sol by the external stimulation according to the property of molecules contained in the gel. The gel comprises a compound represented by the formula(1). In the formula(1), n is an integer from 4 to 20, and each A1 and A2 is independently H, OR, SR, or NHR, wherein R is substituted or unsubstituted C1-30 alkyl, substituted or unsubstituted C2-30 alkenyl, substituted or unsubstituted C2-30 alkynyl, substituted or unsubstituted C2-30 carbonylalkyl, substituted or unsubstituted C1-30 thioalkyl, substituted or unsubstituted C1-30 alkylthiol, substituted or unsubstituted C1-30 hydroxyalkyl, substituted or unsubstituted C1-30 alkylsilyl, substituted or unsubstituted C1-30 aminoalkyl, substituted or unsubstituted C1-30 amino alkylthioalkyl, substituted or unsubstituted C5-30 cycloalkyl, substituted or unsubstituted C2-30 heterocycloalkyl, substituted or unsubstituted C6-30 aryl, substituted or unsubstituted C6-20 arylalkyl, substituted or unsubstituted C4-30 heteroaryl, and substituted or unsubstituted C4-30 heteroarylalkyl. The method for preparing the gel comprises the steps of: (a) dissolving the compound of the formula(1) in a solvent to prepare a sol; (b) adding a pharmacologically active ingredient to the sol; and (c) converting the pharmacologically active ingredient added sol into a gel.

    Abstract translation: 提供了包含葫芦巴的凝胶，其通过各种方法制备，并且能够包括各种化合物，并且根据凝胶中包含的分子的性质，通过外部刺激，制备包含药物和能够转化成溶胶的凝胶。 凝胶包含由式（1）表示的化合物。 在式（1）中，n是4至20的整数，并且每个A 1和A 2独立地是H，OR，SR或NHR，其中R是取代或未取代的C 1-30烷基，取代或未取代的C 2-30烯基 取代或未取代的C 2-30炔基，取代或未取代的C 2-30羰基烷基，取代或未取代的C 1-30硫代烷基，取代或未取代的C 1-30烷基硫醇，取代或未取代的C 1-30羟基烷基，取代或未取代的C 1-30烷基甲硅烷基， 或未取代的C 1-30氨基烷基，取代或未取代的C 1-30氨基烷硫基烷基，取代或未取代的C 5-30环烷基，取代或未取代的C 2-30杂环烷基，取代或未取代的C 6-30芳基，取代或未取代的C 6-20芳烷基， 未取代的C 4-30杂芳基和取代或未取代的C 4-30杂芳基烷基。 制备凝胶的方法包括以下步骤：（a）将式（1）化合物溶于溶剂中以制备溶胶; （b）向所述溶胶中加入药理活性成分; 和（c）将药理活性成分加入的溶胶转化成凝胶。

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