公开(公告)号：WO2015083166A1

公开(公告)日：2015-06-11

申请号：PCT/IL2014/051057

申请日：2014-12-04

Applicant: POCARED DIAGNOSTICS LTD.

Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

IPC: C12N7/02 ,  B01D27/14 ,  G01N33/487 ,  B01D61/18 ,  B01D61/20

CPC classification number: B01D29/0095 ,  B01D37/00 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/065 ,  C12Q1/24 ,  G01F15/125 ,  G01G17/06 ,  G01N1/2813 ,  G01N1/30 ,  G01N1/4077 ,  G01N5/02 ,  G01N33/493 ,  G01N2001/4088 ,  G01N2015/0053 ,  Y10T436/25375

Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.

Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面上捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积的流体中的颗粒浓度 进一步分析。 还可以使用使用滑阀的构造。 此外，供应和接收容器的布置可以用于最小化所需容器的数量。 可以结合质量流量计来测量洗脱流体的流动。 最后，过滤过程的洗涤阶段可用于在颗粒上引入污染物用于进一步分析，例如与革兰氏染色相关的染色，并且可以进一步分析这些染色的颗粒。

公开(公告)号：WO2008107881A2

公开(公告)日：2008-09-12

申请号：PCT/IL2008/000283

申请日：2008-03-05

Applicant: POCARED DIAGNOSTICS LTD. ,  INGBER, Gal ,  GURFINKEL, Jonathan

Inventor： INGBER, Gal ,  GURFINKEL, Jonathan

IPC: C12Q1/18

CPC classification number: G01N33/9446

Abstract: The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the bacteria in the bacterial sample; obtaining a control sample from the bacterial sample; placing the bacterial sample in solutions containing the set of antibiotics; determining concentration of bacteria in the respective antibiotic solutions; determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration; and comparing the growth curves for the respective antibiotic solutions with a growth curve determined from the control sample. An identification and quantification system may be used to select the set of antibiotics, and further may be used in the steps of determining concentration of bacteria in the respective antibiotic solutions and determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration.

Abstract translation: 该方法包括获得细菌样品的几个步骤; 鉴定细菌样品中细菌的类型; 根据细菌样本中细菌的特征选择一组抗生素; 从细菌样品获得对照样品; 将细菌样品置于含有该组抗生素的溶液中; 确定各抗生素溶液中​​细菌的浓度; 基于确定的细菌浓度确定各抗生素溶液的生长曲线; 并将各抗生素溶液的生长曲线与从对照样品测定的生长曲线进行比较。 可以使用鉴定和定量系统来选择该组抗生素，并且还可以用于确定各抗生素溶液中​​的细菌浓度并基于确定的细菌浓度确定各抗生素溶液的生长曲线的步骤。

公开(公告)号：WO2016142825A1

公开(公告)日：2016-09-15

申请号：PCT/IB2016/051247

申请日：2016-03-04

Applicant: POCARED DIAGNOSTICS LTD.

Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

IPC: G06F19/00

CPC classification number: G01N21/6486 ,  C12Q1/04 ,  G01N33/4833 ,  G01N2021/6417 ,  G01N2201/062 ,  G01N2201/129

Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.

Abstract translation: 本发明涉及允许从不含基因的相似分离物中分离含有特异抗生素抗性基因的常见细菌的分离物的方法。 更具体地，本发明涉及利用采用固有荧光，光学数据分析和人工智能方法来分析细菌菌株的多维光学特性的自动化快速平台系统的方法。

公开(公告)号：WO2009049171A3

公开(公告)日：2009-04-16

申请号：PCT/US2008/079533

申请日：2008-10-10

Applicant: POCARED DIAGNOSTICS LTD. ,  INGBER, Gal ,  ATTERBURY, William, G. ,  BARNES, Russell, H. ,  BOYD, Douglas, E. ,  DENNIS, Joseph, D. ,  GURFINKEL, Jonathan ,  HOLLEY, Dave ,  HUCKABY, Steven, E. ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SADESKI, Kevin ,  SCHAEFER, Jason, A. ,  SCOTT, K., Bryan ,  STILLMAN, Carol ,  TALBERT, Sherwood ,  TALLARICO, John

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  BARNES, Russell, H. ,  BOYD, Douglas, E. ,  DENNIS, Joseph, D. ,  GURFINKEL, Jonathan ,  HOLLEY, Dave ,  HUCKABY, Steven, E. ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SADESKI, Kevin ,  SCHAEFER, Jason, A. ,  SCOTT, K., Bryan ,  STILLMAN, Carol ,  TALBERT, Sherwood ,  TALLARICO, John

IPC: C12Q1/04 ,  G01N33/493

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

公开(公告)号：EP3265941A1

公开(公告)日：2018-01-10

申请号：EP16761164.9

申请日：2016-03-04

Applicant: Pocared Diagnostics Ltd.

Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

IPC: G06F19/00

CPC classification number: G01N21/6486 ,  C12Q1/04 ,  G01N33/4833 ,  G01N2021/6417 ,  G01N2201/062 ,  G01N2201/129

Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.

公开(公告)号：EP2209904B1

公开(公告)日：2017-03-01

申请号：EP08837688.4

申请日：2008-10-10

Applicant: Pocared Diagnostics Ltd.

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  BARNES, Russell, H. ,  BOYD, Douglas, E. ,  DENNIS, Joseph, D. ,  GURFINKEL, Jonathan ,  HOLLEY, Dave ,  HUCKABY, Steven, E. ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SADESKI, Kevin ,  SCHAEFER, Jason, A. ,  SCOTT, K., Bryan ,  STILLMAN, Carol ,  TALBERT, Sherwood ,  TALLARICO, John

IPC: C12Q1/04 ,  G01N33/49 ,  G01N33/493 ,  G01N35/02 ,  G01N21/03 ,  G01N21/64 ,  G01N35/04

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

公开(公告)号：EP3077505A1

公开(公告)日：2016-10-12

申请号：EP14868655.3

申请日：2014-12-04

Applicant: Pocared Diagnostics Ltd

Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

IPC: C12N7/02 ,  B01D27/14 ,  G01N33/487 ,  B01D61/18 ,  B01D61/20

CPC classification number: B01D29/0095 ,  B01D37/00 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/065 ,  C12Q1/24 ,  G01F15/125 ,  G01G17/06 ,  G01N1/2813 ,  G01N1/30 ,  G01N1/4077 ,  G01N5/02 ,  G01N33/493 ,  G01N2001/4088 ,  G01N2015/0053 ,  Y10T436/25375

Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.

公开(公告)号：EP2209904A2

公开(公告)日：2010-07-28

申请号：EP08837688.4

申请日：2008-10-10

Applicant: Pocared Diagnostics Ltd.

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  BARNES, Russell, H. ,  BOYD, Douglas, E. ,  DENNIS, Joseph, D. ,  GURFINKEL, Jonathan ,  HOLLEY, Dave ,  HUCKABY, Steven, E. ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SADESKI, Kevin ,  SCHAEFER, Jason, A. ,  SCOTT, K., Bryan ,  STILLMAN, Carol ,  TALBERT, Sherwood ,  TALLARICO, John

IPC: C12Q1/04 ,  G01N33/49

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.