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公开(公告)号：WO2012109600A3
公开(公告)日：2013-11-28
申请号：PCT/US2012024741
申请日：2012-02-10
Applicant: RAINDANCE TECHNOLOGIES INC , YURKOVETSKY YEVGENY , LINK DARREN , LARSON JONATHAN WILLIAM
Inventor： YURKOVETSKY YEVGENY , LINK DARREN , LARSON JONATHAN WILLIAM
IPC: C12Q1/68
CPC classification number: B01F13/0076 , B01F3/0803 , B01F3/0865 , B01F5/0085 , B01F5/0471 , B01F5/0473 , B01F13/0062 , B01F13/0071 , B01F2215/0037 , B01L3/502784 , B01L7/525 , B01L2200/0652 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487
Abstract: Methods involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet. Methods for merging two liquid phases in which only one phase is in the form of a droplet at least at the point of merging A second phase is injected into the drops directly from a continuous stream. Methods of the invention provide a simple and reliable approach to sample fluid mixing because only one of the two phases is dispersed as a droplet prior to its merge with the other phase.
Abstract translation: 方法包括形成液滴并使液滴与流体流接触，其中流体流的一部分与液滴一体化以形成混合液滴。 用于合并两个液相的方法，其中至少在合并点只有一相是液滴的形式将第二相直接从连续流注入到液滴中。 本发明的方法提供了一种简单可靠的样品流体混合方法，因为在与其它相合并之前，两相中只有一相作为液滴分散。
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公开(公告)号：WO2012045012A3
公开(公告)日：2012-07-19
申请号：PCT/US2011054353
申请日：2011-09-30
Applicant: RAINDANCE TECHNOLOGIES INC , SAMUELS MICHAEL , LINK DARREN
Inventor： SAMUELS MICHAEL , LINK DARREN
CPC classification number: G01N33/54366 , C12Q1/6874
Abstract: Methods of performing sandwich assays in droplets are disclosed. Further disclosed are methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte; separating the complexes, and detecting the complexes, thereby detecting the target analyte.
Abstract translation: 公开了以液滴形式进行夹心测定的方法。 进一步公开的是用于检测目标分析物的方法，其包括形成包含疑似含有目标分析物的样品的一部分和样品标识符的流体的分隔部分，具有目标标识的第一结合剂和特异性的第二结合剂 在产生第一和第二结合剂与目标分析物的复合物的条件下的目标分析物; 分离复合物，检测复合物，从而检测目标分析物。
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3.发明申请MICROFLUIDIC SYSTEMS AND METHODS FOR REDUCING THE EXCHANGE OF MOLECULES BETWEEN DROPLETS 审中-公开用于减少小滴之间分子交换的微流体系统和方法
公开(公告)号：WO2011079176A3
公开(公告)日：2011-11-10
申请号：PCT/US2010061741
申请日：2010-12-22
Applicant: RAINDANCE TECHNOLOGIES INC , UNIV STRASBOURG , KLEINSCHMIDT FELIX , GRIFFITHS ANDREW D , CARON FRANCOIS , EL HARRAK ABDESLAM , BROUZES ERIC , LINK DARREN
Inventor： KLEINSCHMIDT FELIX , GRIFFITHS ANDREW D , CARON FRANCOIS , EL HARRAK ABDESLAM , BROUZES ERIC , LINK DARREN
CPC classification number: G01N1/38 , B01L3/502761 , B01L3/502784 , B01L7/52 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0424 , B01L2400/0469 , B01L2400/086 , C12M25/01 , G01N33/5302
Abstract: The present invention generally relates to systems and methods to create stable emulsions with low rates of exchange of molecules between microdroplets.
Abstract translation: 本发明一般涉及用于在微滴之间产生低分子交换速率的稳定乳液的系统和方法。
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公开(公告)号：EP2673614A4
公开(公告)日：2016-05-11
申请号：EP12745382
申请日：2012-02-10
Applicant: RAINDANCE TECHNOLOGIES INC
Inventor： YURKOVETSKY YEVGENY , LINK DARREN , LARSON JONATHAN WILLIAM
IPC: C12Q1/68
CPC classification number: B01F13/0076 , B01F3/0803 , B01F3/0865 , B01F5/0085 , B01F5/0471 , B01F5/0473 , B01F13/0062 , B01F13/0071 , B01F2215/0037 , B01L3/502784 , B01L7/525 , B01L2200/0652 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487
Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.
Abstract translation: 本发明一般涉及形成混合液滴的方法。 在某些实施方案中，本发明的方法包括形成液滴并使液滴与流体流接触，其中流体流的一部分与液滴形成混合液滴。
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Patent Agency Ranking
公开(公告)号：EP2714970A4
公开(公告)日：2015-10-14
申请号：EP12792253
申请日：2012-06-01
Applicant: RAINDANCE TECHNOLOGIES INC
Inventor： LINK DARREN , SAMUELS MICHAEL
IPC: C12Q1/00
CPC classification number: G01N33/573 , B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C40B40/04 , C40B50/08 , C40B60/10 , G01N21/6428 , G01N21/6445 , G01N33/5008 , G01N33/542 , G01N33/582 , G01N2500/00
Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
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6.发明公开MICROFLUIDIC SYSTEMS AND METHODS FOR REDUCING THE EXCHANGE OF MOLECULES BETWEEN DROPLETS 有权微流体系统和减少分子的液滴之间的交换方法
公开(公告)号：EP2517025A4
公开(公告)日：2016-04-20
申请号：EP10840105
申请日：2010-12-22
Applicant: RAINDANCE TECHNOLOGIES INC , UNIV STRASBOURG
Inventor： KLEINSCHMIDT FELIX , GRIFFITHS ANDREW D , CARON FRANÇOIS , EL HARRAK ABDESLAM , BROUZES ERIC , LINK DARREN
CPC classification number: G01N1/38 , B01L3/502761 , B01L3/502784 , B01L7/52 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0424 , B01L2400/0469 , B01L2400/086 , C12M25/01 , G01N33/5302
Abstract: The present invention generally relates to systems and methods to create stable emulsions with low rates of exchange of molecules between microdroplets.
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7.发明公开THERMOCYCLING DEVICE FOR NUCLEIC ACID AMPLIFICATION AND METHODS OF USE 审中-公开THERMOZYKLIERUNGSVORRICHTUNG用于核酸扩增和使用它们的方法
公开(公告)号：EP2673382A4
公开(公告)日：2016-09-14
申请号：EP12745236
申请日：2012-02-10
Applicant: RAINDANCE TECHNOLOGIES INC
Inventor： LINK DARREN
CPC classification number: B01L3/0265 , B01L3/502784 , B01L7/52 , B01L2200/0642 , B01L2200/0673 , B01L2300/0819 , B01L2300/1827 , B01L2300/185
Abstract: The present invention provides thermocycling devices useful for amplification of nucleic acids in droplets. The thermocycling device utilizes the flow of one or more fluids through a main compartment at temperatures sufficient to conduct a polymerase chain reaction. Methods of amplifying nucleic acids in droplets are also provided.
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公开(公告)号：EP2675819A4
公开(公告)日：2014-12-24
申请号：EP12746483
申请日：2012-02-16
Applicant: RAINDANCE TECHNOLOGIES INC
Inventor： SAMUELS MICHAEL , OLSON JEFFREY CHARLES , WATSON ANDREW , BROWN KEITH , LINK DARREN
IPC: C07H21/00 , C12N15/10 , C12Q1/68 , C40B40/06 , G01N33/543
CPC classification number: C12Q1/6874 , C12N15/1075 , C40B50/08 , G01N33/5436 , G01N33/58
Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
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公开(公告)号：EP2622103A4
公开(公告)日：2014-04-23
申请号：EP11830018
申请日：2011-09-30
Applicant: RAINDANCE TECHNOLOGIES INC
Inventor： SAMUELS MICHAEL , LINK DARREN
CPC classification number: G01N33/54366 , C12Q1/6874
Abstract: The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
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