公开(公告)号：US20030071235A1

公开(公告)日：2003-04-17

申请号：US10247437

申请日：2002-09-20

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Harold Samuel Gamble ,  Samuel John Neil Mitchell ,  Daniel Chia Sheng Bien ,  Stephen Peter Fitzgerald

IPC: F16K031/365

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0094

Abstract: A passive microvalve comprises a substrate having a first aperture. An upper plate is mounted on the substrate and has a second aperture opening into a space defined between the substrate and the upper plate. A closure member is mounted in the space and is movable between a first position in which it allows fluid flow between the first and second apertures and a second position in which it closes the second aperture.

Abstract translation: 被动微型阀包括具有第一孔的基底。 上板安装在基板上，并且具有第二开口，该开口开口限定在基板和上板之间的空间中。 闭合构件安装在该空间中并且可在第一位置和第二位置之间移动，在第一位置，第一位置允许第一和第二孔之间的流体流动，第二位置闭合第二孔。

公开(公告)号：US20030170728A1

公开(公告)日：2003-09-11

申请号：US10295700

申请日：2002-11-15

Applicant: Randox Laboratories Limited

Inventor： Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

IPC: G01N033/53 ,  C07D211/56 ,  C07K016/00 ,  C07K014/47

CPC classification number: G01N33/9486 ,  C07D211/58 ,  G01N33/531 ,  G01N2430/00

Abstract: The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.

Abstract translation: 本发明提供了一种免疫原，其包含与抗原性赋予载体材料偶联的半抗原，包含与标记试剂偶联的上述半抗原的缀合物，以及针对上述免疫原产生并能够与至少一种结构表位结合的抗体 芬太尼代谢物和芬太尼类似物的代谢产物。

公开(公告)号：US20030224447A1

公开(公告)日：2003-12-04

申请号：US10355348

申请日：2003-01-31

Applicant: Randox Laboratories Limited

Inventor： Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

IPC: G01N033/53 ,  C07K014/00

CPC classification number: C07K16/44 ,  A61K47/64 ,  A61K47/646 ,  G01N33/94 ,  Y10S436/815 ,  Y10S436/823 ,  Y10S530/807 ,  Y10T436/13 ,  Y10T436/17

Abstract: The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with ketamine and its primary metabolite, norketamine.

Abstract translation: 本发明提供了半抗原，包含与赋予抗原性的载体材料偶联的这种半抗原的免疫原，包含与标记试剂结合的这种半抗原的缀合物，以及针对这种免疫原而产生并能够与氯胺酮及其主要代谢物诺替胺结合的抗体。

公开(公告)号：US20030215367A1

公开(公告)日：2003-11-20

申请号：US10406224

申请日：2003-04-04

Applicant: Randox Laboratories Limited

Inventor： Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

IPC: B01L003/00

CPC classification number: G01N35/028 ,  B01F11/0022 ,  B01L7/00 ,  G01N2035/00356 ,  G01N2035/00524 ,  Y10S435/809

Abstract: An assay device incubator comprises a housing (46) defining a region within which at least one assay device is located in use, the housing defining laterally opposed sidewalls (48, 50) of at least one bay (33) in which an assay device can be located. The housing (46) includes one or more guides (49, 51) for supporting the assay device and enabling the assay device to undergo to and fro movement therealong. A vibration system (40, 60) is coupled to the at least one tray in use for vibrating the tray to and fro along the or each guide. A heating system (70) heats the region within the housing.

Abstract translation: 测定装置培养箱包括限定其中至少一个测定装置位于使用中的区域的壳体（46），所述壳体限定至少一个隔间（33）的横向相对的侧壁（48,50），其中测定装置可以 位于。 壳体（46）包括用于支撑测定装置的一个或多个引导件（49,51），并且使测定装置能够沿着其移动。 振动系统（40,60）在使用中联接到所述至少一个托盘，用于沿着或每个引导件来回振动托盘。 加热系统（70）加热壳体内的区域。

公开(公告)号：US20020045287A1

公开(公告)日：2002-04-18

申请号：US09881744

申请日：2001-06-18

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Harold S. Gamble ,  S.J. Neil Mitchell ,  Andrzej Prochaska ,  Stephen Peter Fitzgerald

IPC: H01L021/00

CPC classification number: B81C1/00158 ,  B41J2/16 ,  B41J2/1623 ,  B41J2/1628 ,  B41J2/1632 ,  B41J2/1639 ,  B81B2203/0315 ,  B81C2201/0115 ,  B81C2201/0146

Abstract: A method of manufacturing a diaphragm utilizing a precision grinding technique after etching a cavity in a wafer. A technique for preventing distortion of the diaphragm based on use of a sacrificial layer of porous silicon is disclosed.

Abstract translation: 在蚀刻晶片中的空腔之后利用精密研磨技术制造隔膜的方法。 公开了一种基于使用多孔硅牺牲层防止隔膜变形的技术。