公开(公告)号：WO2023081449A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/049103

申请日：2022-11-07

Applicant: RCE TECHNOLOGIES, INC.

Inventor： BURMAN, Atandra ,  TITUS, Jitto ,  BISWAL, Siddharth

IPC: A61B5/026 ,  A61B5/02 ,  A61B5/024 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/341 ,  A61B5/349 ,  A61K31/202 ,  A61K35/12

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

公开(公告)号：WO2023064274A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046281

申请日：2022-10-11

Applicant: RCE TECHNOLOGIES, INC.

Inventor： TITUS, Jitto ,  BISWAL, Siddharth ,  BURMAN, Atandra

IPC: G01N21/27 ,  A61B5/1455

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.