公开(公告)号：WO2023064274A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046281

申请日：2022-10-11

Applicant: RCE TECHNOLOGIES, INC.

Inventor： TITUS, Jitto ,  BISWAL, Siddharth ,  BURMAN, Atandra

IPC: G01N21/27 ,  A61B5/1455

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

公开(公告)号：WO2023081449A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/049103

申请日：2022-11-07

Applicant: RCE TECHNOLOGIES, INC.

Inventor： BURMAN, Atandra ,  TITUS, Jitto ,  BISWAL, Siddharth

IPC: A61B5/026 ,  A61B5/02 ,  A61B5/024 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/341 ,  A61B5/349 ,  A61K31/202 ,  A61K35/12

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

公开(公告)号：WO2021247386A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/034700

申请日：2021-05-28

Applicant: RCE TECHNOLOGIES, INC.

Inventor： TITUS, Jitto ,  BURMAN, Atandra

IPC: A61B5/024 ,  A61B5/1455 ,  G01N21/33 ,  G01N21/35 ,  G01N21/49 ,  A61B2562/0238 ,  A61B5/14546 ,  A61B5/1495 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/108 ,  G01J3/42 ,  G01N21/552 ,  G01N2201/0221 ,  G01N2201/0696

Abstract: Transdermal optical sensing systems and methods of use are described. The systems include a main body, an internal reflection element arranged within the main body, with an internal reflection element surface exposed for contact with an epidermis, an optical source configured to project light into the internal reflection element, an optical detector arranged to detect reflected light that reflects internally within the internal reflection element from the internal reflection element surface, a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, and a retention member attached to the main body, the retention member configured to wrap about a wrist of a patient.

公开(公告)号：EP4157078A1

公开(公告)日：2023-04-05

申请号：EP21818907.4

申请日：2021-05-28

Applicant: RCE Technologies, Inc.

Inventor： TITUS, Jitto ,  BURMAN, Atandra

IPC: A61B5/024 ,  A61B5/1455 ,  G01N21/33 ,  G01N21/35 ,  G01N21/49