公开(公告)号：WO2023081449A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/049103

申请日：2022-11-07

Applicant: RCE TECHNOLOGIES, INC.

Inventor： BURMAN, Atandra ,  TITUS, Jitto ,  BISWAL, Siddharth

IPC: A61B5/026 ,  A61B5/02 ,  A61B5/024 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/341 ,  A61B5/349 ,  A61K31/202 ,  A61K35/12

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

公开(公告)号：WO2021247386A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/034700

申请日：2021-05-28

Applicant: RCE TECHNOLOGIES, INC.

Inventor： TITUS, Jitto ,  BURMAN, Atandra

IPC: A61B5/024 ,  A61B5/1455 ,  G01N21/33 ,  G01N21/35 ,  G01N21/49 ,  A61B2562/0238 ,  A61B5/14546 ,  A61B5/1495 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/108 ,  G01J3/42 ,  G01N21/552 ,  G01N2201/0221 ,  G01N2201/0696

Abstract: Transdermal optical sensing systems and methods of use are described. The systems include a main body, an internal reflection element arranged within the main body, with an internal reflection element surface exposed for contact with an epidermis, an optical source configured to project light into the internal reflection element, an optical detector arranged to detect reflected light that reflects internally within the internal reflection element from the internal reflection element surface, a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, and a retention member attached to the main body, the retention member configured to wrap about a wrist of a patient.

公开(公告)号：WO2023064274A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046281

申请日：2022-10-11

Applicant: RCE TECHNOLOGIES, INC.

Inventor： TITUS, Jitto ,  BISWAL, Siddharth ,  BURMAN, Atandra

IPC: G01N21/27 ,  A61B5/1455

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

公开(公告)号：US12201419B2

公开(公告)日：2025-01-21

申请号：US17537932

申请日：2021-11-30

Applicant: RCE Technologies, Inc.

Inventor： Jitto Titus ,  Atandra Burman

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/026 ,  A61B5/145

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

公开(公告)号：US20210353203A1

公开(公告)日：2021-11-18

申请号：US17319169

申请日：2021-05-13

Applicant: RCE Technologies, Inc.

Inventor： Atandra Burman ,  Jitto Titus ,  Siddharth Biswal

IPC: A61B5/341 ,  A61B5/28 ,  A61B5/0245 ,  A61B5/024 ,  A61B5/00 ,  G16H10/60

Abstract: Aspects of the invention include a computer-implemented method that includes generating an intermediate ECG vector representation and an intermediate optical sensor vector representation. The intermediate ECG vector representation and the intermediate optical sensor vector representation is translated to a joint representation in a vector space. The similarities detected between the electrocardiogram (ECG) data and optical sensor data from the joint vector space representation. Features that are indicative of an ischemic disease of a patient are extracted from the joint vector space representation based at least in part on the detected similarities. The ischemic disease of the patient is detected based at least in part on the extracted features.

公开(公告)号：US20240252075A1

公开(公告)日：2024-08-01

申请号：US18625438

申请日：2024-04-03

Applicant: RCE TECHNOLOGIES, INC.

Inventor： Atandra Burman ,  Jitto Titus ,  Siddharth Biswal

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1455 ,  G16H40/40

CPC classification number: A61B5/1495 ,  A61B5/14546 ,  A61B5/1455 ,  G16H40/40 ,  A61B2560/0238

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

公开(公告)号：US11257591B2

公开(公告)日：2022-02-22

申请号：US16597933

申请日：2019-10-10

Applicant: RCE Technologies, Inc.

Inventor： Atandra Burman ,  Jitto Titus

IPC: G16H40/67 ,  A61B5/1455 ,  A61K35/12 ,  A61K31/202 ,  A61B5/00 ,  A61B5/02 ,  A61B5/145 ,  G02B6/032 ,  G01N21/65

Abstract: As described herein, a system includes an optical sensor, and a controller that detects progression of obstructive coronary artery disease using a sensor signal from the optical sensor. For example, the system is used for detecting an occlusion in a cardiovascular system of a user. A computer-implemented method for detecting the occlusion includes generating a light within a predetermined spectral range, the light directed towards a reflective element at a predetermined angle. The method further includes receiving a reflected light caused by a reflection of the light off of a reflecting element that is in contact with the user's epidermis. The method further includes detecting a concentration of a predetermined biomarker in a biofluid in the cardiovascular system based on variations in amplitude of the reflected light. The method further includes determining an occlusion in the cardiovascular system based on the concentration of the predetermined biomarker.

公开(公告)号：US12138051B2

公开(公告)日：2024-11-12

申请号：US18625438

申请日：2024-04-03

Applicant: RCE Technologies, Inc.

Inventor： Atandra Burman ,  Jitto Titus ,  Siddharth Biswal

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1455 ,  G16H40/40

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

公开(公告)号：US20240206776A1

公开(公告)日：2024-06-27

申请号：US18596210

申请日：2024-03-05

Applicant: RCE Technologies, Inc.

Inventor： Atandra Burman ,  Jitto Titus ,  T David Gbadebo

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/026 ,  A61B5/145

CPC classification number: A61B5/1455 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/14546

Abstract: A personalized assistance system includes an infrasensor device adapted to collect input data from a subject. A controller is configured to receive the input data from the infrasensor device. The controller has a processor and tangible, non-transitory memory on which instructions are recorded and is adapted to selectively execute one or more machine learning modules. Execution of the instructions by the processor causes the controller to extract one or more inframarkers from the input data. The controller is configured to determine respective changes in the inframarkers in real-time, including deviations from a respective baseline measurement customized for the subject. The controller is configured to determine at least one recommendation based in part on the inframarkers and the respective changes, via the one or more machine learning modules. The recommendation is executed when a predefined threshold is met.

公开(公告)号：US20220079473A1

公开(公告)日：2022-03-17

申请号：US17537932

申请日：2021-11-30

Applicant: RCE Technologies, Inc.

Inventor： Jitto Titus ,  Atandra Burman

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/026

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.