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公开(公告)号:US12201419B2
公开(公告)日:2025-01-21
申请号:US17537932
申请日:2021-11-30
Applicant: RCE Technologies, Inc.
Inventor: Jitto Titus , Atandra Burman
IPC: A61B5/1455 , A61B5/00 , A61B5/026 , A61B5/145
Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.
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公开(公告)号:US20210353203A1
公开(公告)日:2021-11-18
申请号:US17319169
申请日:2021-05-13
Applicant: RCE Technologies, Inc.
Inventor: Atandra Burman , Jitto Titus , Siddharth Biswal
Abstract: Aspects of the invention include a computer-implemented method that includes generating an intermediate ECG vector representation and an intermediate optical sensor vector representation. The intermediate ECG vector representation and the intermediate optical sensor vector representation is translated to a joint representation in a vector space. The similarities detected between the electrocardiogram (ECG) data and optical sensor data from the joint vector space representation. Features that are indicative of an ischemic disease of a patient are extracted from the joint vector space representation based at least in part on the detected similarities. The ischemic disease of the patient is detected based at least in part on the extracted features.
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公开(公告)号:US20240252075A1
公开(公告)日:2024-08-01
申请号:US18625438
申请日:2024-04-03
Applicant: RCE TECHNOLOGIES, INC.
Inventor: Atandra Burman , Jitto Titus , Siddharth Biswal
IPC: A61B5/1495 , A61B5/145 , A61B5/1455 , G16H40/40
CPC classification number: A61B5/1495 , A61B5/14546 , A61B5/1455 , G16H40/40 , A61B2560/0238
Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.
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公开(公告)号:US11257591B2
公开(公告)日:2022-02-22
申请号:US16597933
申请日:2019-10-10
Applicant: RCE Technologies, Inc.
Inventor: Atandra Burman , Jitto Titus
IPC: G16H40/67 , A61B5/1455 , A61K35/12 , A61K31/202 , A61B5/00 , A61B5/02 , A61B5/145 , G02B6/032 , G01N21/65
Abstract: As described herein, a system includes an optical sensor, and a controller that detects progression of obstructive coronary artery disease using a sensor signal from the optical sensor. For example, the system is used for detecting an occlusion in a cardiovascular system of a user. A computer-implemented method for detecting the occlusion includes generating a light within a predetermined spectral range, the light directed towards a reflective element at a predetermined angle. The method further includes receiving a reflected light caused by a reflection of the light off of a reflecting element that is in contact with the user's epidermis. The method further includes detecting a concentration of a predetermined biomarker in a biofluid in the cardiovascular system based on variations in amplitude of the reflected light. The method further includes determining an occlusion in the cardiovascular system based on the concentration of the predetermined biomarker.
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公开(公告)号:US20240298631A1
公开(公告)日:2024-09-12
申请号:US18596224
申请日:2024-03-05
Applicant: RCE Technologies, Inc.
Inventor: Atandra Burman , Jitto Titus
CPC classification number: A01N1/021 , A01N1/0247 , A01N1/0284 , C12M41/30
Abstract: Method or system for monitoring a condition of an organ, which may be a donor organ, using an optical device; providing a reservoir of normothermic fluid; providing a perfusion circuit for the normothermic fluid; and providing a pump in fluid communication with perfusion circuit. Providing an oxygenator for normothermic fluid during circulation through the perfusion circuit to perfuse the donor heart with oxygenated blood; an optical device integrated within the reservoir, or pump or oxygenator, or in-line flow-based within perfusion circuit through normothermic fluid flows. May use total internal reflection for optical device. Monitoring condition of an organ, circulation system for blood, exterior to a body, but connected to the body; and adding filtration to blood, and filtered blood goes back into body. Monitoring a condition of a heart or lung, using extracorporeal membrane oxygenation (ECMO) to monitor the oxygenation levels in circulation.
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6.
公开(公告)号:US20240293027A1
公开(公告)日:2024-09-05
申请号:US18656821
申请日:2024-05-07
Applicant: RCE Technologies, Inc.
Inventor: Atandra Burman , Jitto Titus , Siddharth Biswal
IPC: A61B5/00
CPC classification number: A61B5/0062 , A61B5/0075 , A61B5/4839 , A61B5/4842 , A61B5/7275 , A61B2562/0238
Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.
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公开(公告)号:USD1028251S1
公开(公告)日:2024-05-21
申请号:US29773727
申请日:2021-03-11
Applicant: RCE Technologies, Inc.
Designer: Atandra Burman , Jitto Titus
Abstract: FIG. 1 is top-down perspective view of a portable transdermal biomarker sensor device, showing our new design;
FIG. 2 is a front elevation view of the embodiment shown in FIG. 1;
FIG. 3 is a rear elevation view of the embodiment shown in FIG. 1;
FIG. 4 is a left-side elevation view of the embodiment shown in FIG. 1;
FIG. 5 is right-side elevation view of the embodiment shown in FIG. 1;
FIG. 6 is a top-down plan view of the embodiment shown in FIG. 1;
FIG. 7 is a bottom-up plan view of the embodiment shown in FIG. 1;
FIG. 8 is a top-down, front perspective view of the embodiment shown in FIG. 1, illustrating the separate elements thereof in a first configuration, with a top-down, rear perspective view being a mirror thereof;
FIG. 9 is a top-down perspective view of the embodiment shown in FIG. 1, illustrating the separate elements thereof in a second configuration, with a top-down, rear perspective view being a mirror thereof;
FIG. 10 is a top-down, front perspective view of the embodiment shown in FIG. 1, illustrating the separate elements thereof in a third configuration, with a top-down, rear perspective view being a mirror thereof; and,
FIG. 11 is a bottom-up perspective of the embodiment shown in FIG. 1, illustrating the separate elements thereof, with a bottom-up, rear perspective view being a mirror thereof.
The dot-dash lines in the drawings represent the bounds of the claimed design and form no part thereof. The even length broken lines illustrate portions of the portable transdermal biomarker sensor device that form no part of the claimed design.-
公开(公告)号:US12138051B2
公开(公告)日:2024-11-12
申请号:US18625438
申请日:2024-04-03
Applicant: RCE Technologies, Inc.
Inventor: Atandra Burman , Jitto Titus , Siddharth Biswal
IPC: A61B5/1495 , A61B5/145 , A61B5/1455 , G16H40/40
Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.
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9.
公开(公告)号:US20240206776A1
公开(公告)日:2024-06-27
申请号:US18596210
申请日:2024-03-05
Applicant: RCE Technologies, Inc.
Inventor: Atandra Burman , Jitto Titus , T David Gbadebo
IPC: A61B5/1455 , A61B5/00 , A61B5/026 , A61B5/145
CPC classification number: A61B5/1455 , A61B5/0075 , A61B5/0261 , A61B5/14546
Abstract: A personalized assistance system includes an infrasensor device adapted to collect input data from a subject. A controller is configured to receive the input data from the infrasensor device. The controller has a processor and tangible, non-transitory memory on which instructions are recorded and is adapted to selectively execute one or more machine learning modules. Execution of the instructions by the processor causes the controller to extract one or more inframarkers from the input data. The controller is configured to determine respective changes in the inframarkers in real-time, including deviations from a respective baseline measurement customized for the subject. The controller is configured to determine at least one recommendation based in part on the inframarkers and the respective changes, via the one or more machine learning modules. The recommendation is executed when a predefined threshold is met.
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公开(公告)号:US20220079473A1
公开(公告)日:2022-03-17
申请号:US17537932
申请日:2021-11-30
Applicant: RCE Technologies, Inc.
Inventor: Jitto Titus , Atandra Burman
IPC: A61B5/1455 , A61B5/145 , A61B5/026
Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.
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