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公开(公告)号：DE60028665D1
公开(公告)日：2006-07-27
申请号：DE60028665
申请日：2000-08-03
Applicant: THK CO LTD , RIKEN WAKO
Inventor： NAKAZAWA THK CO , IIMURA AKIHIRO , TASHIRO HIDEO , KITSUNAI TOKUJI , HAYASHIZAKI YOSHIHIDE
Abstract: The present invention relates to a micro array manufacturing apparatus, comprising: a working table 11 on which a plurality of substrates are arranged; a first solution storing portion 12 for storing a solution 53 including a living body sample; hold means for taking in said solution from said first solution storing portion 12 to form the spot of said solution on each of said substrates; moving means for supporting said hold means and moving said hold means in directions where said hold means approaches and retreats from said substrates, thereby allowing said hold means to form said solution spot; and delivery means for supporting said moving means and delivering said moving means in an area including said working table and said solution storing portion to provide two-dimensional coordinates; wherein said hold means comprises a second solution storing portion 52 having a pipe shape for storing a quantity of said solution to form the spots successively, the second solution storing portion 52 having an opening on one end thereof, and a needle 51 having a leading end portion stored in said second solution storing portion 52, the leading end portion being projectable from said second storing portion 52 by said moving means through the opening to allow said solution stored in said second solution storing portion to adhere onto each of said substrates by a given quantity.
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公开(公告)号：DE60028665T2
公开(公告)日：2007-06-06
申请号：DE60028665
申请日：2000-08-03
Applicant: THK CO LTD , RIKEN WAKO
Inventor： NAKAZAWA TOJI , IIMURA AKIHIRO , TASHIRO HIDEO , KITSUNAI TOKUJI , HAYASHIZAKI YOSHIHIDE
Abstract: The present invention relates to a micro array manufacturing apparatus, comprising: a working table 11 on which a plurality of substrates are arranged; a first solution storing portion 12 for storing a solution 53 including a living body sample; hold means for taking in said solution from said first solution storing portion 12 to form the spot of said solution on each of said substrates; moving means for supporting said hold means and moving said hold means in directions where said hold means approaches and retreats from said substrates, thereby allowing said hold means to form said solution spot; and delivery means for supporting said moving means and delivering said moving means in an area including said working table and said solution storing portion to provide two-dimensional coordinates; wherein said hold means comprises a second solution storing portion 52 having a pipe shape for storing a quantity of said solution to form the spots successively, the second solution storing portion 52 having an opening on one end thereof, and a needle 51 having a leading end portion stored in said second solution storing portion 52, the leading end portion being projectable from said second storing portion 52 by said moving means through the opening to allow said solution stored in said second solution storing portion to adhere onto each of said substrates by a given quantity.
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公开(公告)号：DE112005000477T5
公开(公告)日：2007-01-18
申请号：DE112005000477
申请日：2005-02-17
Applicant: YOKOGAWA ELECTRIC CORP , RIKEN WAKO
Inventor： TANAAMI TAKEO , TASHIRO HIDEO
Abstract: The invention provides a substrate for biopolymer hybridization, a biopolymer hybridization device, and a biopolymer hybridization method capable of: speeding up hybridization of a biopolymer, by means of dielectrophoresis or electrophoresis by applying an alternating voltage or a direct voltage to a planar electrode, so as to generate an electric field; and reading the hybridized biopolymer by means of a laser or the like.
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公开(公告)号：DE60045451D1
公开(公告)日：2011-02-10
申请号：DE60045451
申请日：2000-08-03
Applicant: RIKEN , THK CO LTD
Inventor： NAKAZAWA TOJI , IIMURA AKIHIRO , TASHIRO HIDEO , KITSUNAI TOKUJI , HAYASHIZAKI YOSHIHIDE
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公开(公告)号：CA2363820A1
公开(公告)日：2002-05-24
申请号：CA2363820
申请日：2001-11-23
Applicant: RIKEN , UNIV WASEDA
Inventor： KONDOH YASUMITSU , TASHIRO HIDEO , KITSUNAI TOKUJI , NOJIMA TAKAHIKO , TAKENAKA SHIGEORI , MATSUMOTO KAZUKO
IPC: G01N31/22 , B01J19/00 , C07K1/04 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N37/00 , G01N33/531 , G01N33/543
Abstract: A biomolecule microarray support for spotting solutions containing probe biomolecules on the surface and immobilizing the probe biomolecules in the solutions to the surface, characterized in that a plurality of small-sized probe biomolecule-attachable spots are arrayed in a regular arrangement on the surface of the support. A biomolecule microarray, made by spotting solutions containing probe biomolecules on the biomolecule-attachable spots on the support and immobilizing the biomolecules to the spots, can be used for quantitative analysis because of uniform and unvarying numbers of probe biomolecules bound to the spots. It also makes possible high S/N ratio measurement because of prevented nonspecific adsorption of target biomolecules to the surface of the support other than the detection spots. The biomolecule microarray support is fabricated precisely and efficiently by the method of the present invention using the photolithography and etching technique.
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Patent Agency Ranking
公开(公告)号：CA2358011A1
公开(公告)日：2002-03-26
申请号：CA2358011
申请日：2001-09-24
Applicant: RIKEN
Inventor： KITSUNAI TOKUJI , TASHIRO TOMOKO , KONDOH YASUMITSU , TASHIRO HIDEO
IPC: G01N33/53 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/58 , G01N37/00 , G01N35/00 , C12Q1/00 , G01N33/533
Abstract: An integrated biomolecule sensor comprising a plurality of optical fibers whose proximal ends are held together with the end-faces arranged substantially in the same plane and oriented substantially in the same direction and which have probe polymers with different base sequences bound to the core end-face at their distal ends. The method and apparatus for fabricating the integrated biomolecule sensor, and the method and apparatus for detecting biomolecules using the integrated biomolecule sensor are also disclosed. Researchers can make their own sensors best suited for individual requirements, and detect the presence of target biomolecules quickly, without need of expensive equipment.
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公开(公告)号：CA2309071A1
公开(公告)日：2000-11-27
申请号：CA2309071
申请日：2000-05-19
Applicant: RIKEN
Inventor： TASHIRO HIDEO , KASE KIWAMU
Abstract: (A) The surface shape of an object (1) is measured by varying the position and/or direction of measurement, and a plurality of sets of partially measured data (2) including the common parts (2a) are acquired, (B) for all the partially measured data (2), the overlapped ranges (3a) of the adjacent common parts (2a) are determined within the measurement error ranges (3), (C) when there are no superposition ranges (3a), it is decided that a combination is not possible, and (D) when there are overlapped ranges (3a), the common parts of each set of partially measured data are combined within the ranges. Thus, combined data can be created at a high accuracy from a plurality of sets of partially measured data based on a small number of repeated calculations.
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公开(公告)号：DE60237020D1
公开(公告)日：2010-08-26
申请号：DE60237020
申请日：2002-08-14
Applicant: RIKEN WAKO
Inventor： OHMORI HITOSHI , ANZAI MASAHIRO , KASE KIWAMU , TASHIRO HIDEO , MAKINOUCHI AKITAKE
IPC: G05B19/4097 , G05B19/4069
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公开(公告)号：DE60224285T2
公开(公告)日：2009-01-02
申请号：DE60224285
申请日：2002-08-14
Applicant: RIKEN WAKO
Inventor： OHMORI HITOSHI , ANZAI MASAHIRO , KASE KIWAMU , TASHIRO HIDEO , MAKINOUCHI AKITAKE
IPC: G05B19/4097 , B29C67/00
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公开(公告)号：DE60224285D1
公开(公告)日：2008-02-07
申请号：DE60224285
申请日：2002-08-14
Applicant: RIKEN WAKO
Inventor： OHMORI HITOSHI , ANZAI MASAHIRO , KASE KIWAMU , TASHIRO HIDEO , MAKINOUCHI AKITAKE
IPC: G05B19/4097 , B29C67/00
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