公开(公告)号：AT84044T

公开(公告)日：1993-01-15

申请号：AT87109318

申请日：1987-06-29

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANA ,  CENSINI STEFANO ,  DI TRAPANI ROMANO

IPC: C07K1/00 ,  C07K5/02 ,  A61K37/02

公开(公告)号：IT8621145D0

公开(公告)日：1986-07-16

申请号：IT2114586

申请日：1986-07-16

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANO ,  CENSINI STEFANO

IPC: A61K20060101 ,  A61K

公开(公告)号：ES2052517T3

公开(公告)日：1994-07-16

申请号：ES87109318

申请日：1987-06-29

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANA ,  CENSINI STEFANO ,  DI TRAPANI ROMANO

IPC: A61K39/39 ,  A61K38/00 ,  A61K38/43 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  C07C271/22 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/10 ,  C07K1/00 ,  A61K37/02

Abstract: New partially retro-inverted tuftsin analogues of general formula I wherein R represents the side-chain of the amino acids threonine, methionine or leucine R represents the side-chain of the amino acids lysine or arginine R is hydrogen or a metabolically labile acyl group, all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.

公开(公告)号：DE69004900T2

公开(公告)日：1994-06-16

申请号：DE69004900

申请日：1990-08-27

Applicant: SCLAVO SPA

Inventor： VISCOMI GIUSEPPE CLAUDIO ,  CARDINALI FRANCO ,  LONGOBARDI MARIA GRAZIA

IPC: C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02

Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

公开(公告)号：DE3783280D1

公开(公告)日：1993-02-11

申请号：DE3783280

申请日：1987-06-29

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANA ,  CENSINI STEFANO ,  DI TRAPANI ROMANO

IPC: A61K39/39 ,  A61K38/00 ,  A61K38/43 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  C07C271/22 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/10 ,  C07K1/00 ,  A61K37/02

Abstract: New partially retro-inverted tuftsin analogues of general formula I wherein R represents the side-chain of the amino acids threonine, methionine or leucine R represents the side-chain of the amino acids lysine or arginine R is hydrogen or a metabolically labile acyl group, all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.

公开(公告)号：IT1232311B

公开(公告)日：1992-01-28

申请号：IT2161389

申请日：1989-09-04

Applicant: SCLAVO SPA

Inventor： VISCOMI GIUSEPPE CLAUDIO ,  CARDINALI FRANCO ,  LONGOBARDI MARIA GRAZIA

IPC: C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02 ,  B01D

Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

公开(公告)号：IT8921613D0

公开(公告)日：1989-09-04

申请号：IT2161389

申请日：1989-09-04

Applicant: SCLAVO SPA

Inventor： VISCOMI GIUSEPPE CLAUDIO ,  CARDINALI FRANCO ,  LONGOBARDI MARIA GRAZIA

IPC: C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02

Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

公开(公告)号：CA2024250A1

公开(公告)日：1991-03-05

申请号：CA2024250

申请日：1990-08-29

Applicant: SCLAVO SPA

Inventor： VISCOMI GIUSEPPE C ,  CARDINALI FRANCO ,  LONGOBARDI MARIA G

IPC: C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02

Abstract: METHOD FOR PURIFYING LOW MOLECULAR WEIGHT COMPOUNDS OF PEPTIDE OR PSEUDO-PEPTIDE STRUCTURE This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

公开(公告)号：ES2060881T3

公开(公告)日：1994-12-01

申请号：ES90116366

申请日：1990-08-27

Applicant: SCLAVO SPA

Inventor： VISCOMI GIUSEPPE CLAUDIO ,  CARDINALI FRANCO ,  LONGOBARDI MARIA GRAZIA

IPC: C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02

Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

公开(公告)号：DE69004900D1

公开(公告)日：1994-01-13

申请号：DE69004900

申请日：1990-08-27

Applicant: SCLAVO SPA

Inventor： VISCOMI GIUSEPPE CLAUDIO ,  CARDINALI FRANCO ,  LONGOBARDI MARIA GRAZIA

IPC: C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02

Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.