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公开(公告)号：IT9021565A1
公开(公告)日：1992-03-26
申请号：IT2156590
申请日：1990-09-25
Applicant: SCLAVO SPA
Inventor： PESSI ANTONELLO , RAPPUOLI PAOLO , SCAPOL LUCIA , VISCOMI GIUSEPPE CLAUDIO
IPC: A61K20060101 , C07C20060101
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公开(公告)号：DE69004900T2
公开(公告)日：1994-06-16
申请号：DE69004900
申请日：1990-08-27
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , CARDINALI FRANCO , LONGOBARDI MARIA GRAZIA
Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
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公开(公告)号：IT1232311B
公开(公告)日：1992-01-28
申请号：IT2161389
申请日：1989-09-04
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , CARDINALI FRANCO , LONGOBARDI MARIA GRAZIA
Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
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公开(公告)号：IT8921613D0
公开(公告)日：1989-09-04
申请号：IT2161389
申请日：1989-09-04
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , CARDINALI FRANCO , LONGOBARDI MARIA GRAZIA
Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
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公开(公告)号：IT1243419B
公开(公告)日：1994-06-10
申请号：IT2156590
申请日：1990-09-25
Applicant: SCLAVO SPA
Inventor： SCAPOL LUCIA , PESSI ANTONELLO , RAPPUOLI PAOLO , VISCOMI GIUSEPPE CLAUDIO
IPC: A61K20060101 , C07C20060101 , A61K , C07C
Abstract: Antiparallel oligopeptides, the sequences of which are suitably defined so that they have affinity for β- interferon, and a process for the purification of human β-interferon using stationary phases consisting of inert matrices onto which the said antiparallel peptides are chemically bound, are described.
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Patent Agency Ranking
公开(公告)号：IT9021564A1
公开(公告)日：1992-03-26
申请号：IT2156490
申请日：1990-09-25
Applicant: SCLAVO SPA
Inventor： RAPPUOLI PAOLO , VISCOMI GIUSEPPE CLAUDIO
IPC: A61K20060101
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公开(公告)号：ES2060881T3
公开(公告)日：1994-12-01
申请号：ES90116366
申请日：1990-08-27
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , CARDINALI FRANCO , LONGOBARDI MARIA GRAZIA
Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
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公开(公告)号：IT1243418B
公开(公告)日：1994-06-10
申请号：IT2156490
申请日：1990-09-25
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , RAPPUOLI PAOLO
IPC: A61K20060101 , A61K
Abstract: A process is described for the purification of recombinant human β-interferon, which involves the use of three chromatographic stages, performed in series using as stationary phases: glass particles of controlled porosity, polymeric cation exchange resins, and polymeric resins capable of complexing heavy metals.
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公开(公告)号：DE69004900D1
公开(公告)日：1994-01-13
申请号：DE69004900
申请日：1990-08-27
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , CARDINALI FRANCO , LONGOBARDI MARIA GRAZIA
Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
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公开(公告)号：AT97911T
公开(公告)日：1993-12-15
申请号：AT90116366
申请日：1990-08-27
Applicant: SCLAVO SPA
Inventor： VISCOMI GIUSEPPE CLAUDIO , CARDINALI FRANCO , LONGOBARDI MARIA GRAZIA
Abstract: This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
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