公开(公告)号：JPH04210924A

公开(公告)日：1992-08-03

申请号：JP1683291

申请日：1991-01-18

Applicant: SCLAVO SPA

Inventor： FUIRITSUPO RATSUTANTSUI ,  MAURITSUIO CHIEKETSUTEIN ,  RITSUKARUDO BUANNI

IPC: A61K9/00 ,  A61K9/20 ,  A61K38/23 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61P3/00

Abstract: PURPOSE: To obtain a pharmaceutical composition capable of providing blood concentration having same level as blood concentration of calcitonin obtainable by conventional intramuscular administration by oral administration at same unit dosage form by homogenizing with a mixture of solid excipients. CONSTITUTION: Perbuccal or sublingual tablets for oral administration contain calcitonin homogenized with a mixture of solid excipients, preferably completely a soluble diluent (especially mannitol, lactose or saccharose), a disintegrator (especially starch, its derivative, micro-crystalline cellulose, its derivative, crospovidone, amberlite, alginic acid) and a lubricant (especially magnesium stearate, aluminum stearate, stearic acid, talc, high molecular weight ethylene glycol) or the above diluent and a binder (especially gum arabic, hydroxypropyl cellulose or hydroxypropylmethyl cellulose) and lubricant, e.g. eel calcitonin in an amount of 20-800I.U., preferably 50-500I.U. per tablet as an active ingredient.